Assessment of the FTO gene polymorphisms
inmale patients with metabolic syndrome

Ślężak, Ryszard; Leszczyński, Przemysław; Warzecha, Magdalena; Łaczmański, Łukasz; Misiak, Błażej

doi:10.17219/acem/75676

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…13 Recently, Ślęzak et al presented a study where FTO gene variation was related to single metabolic disturbances in a homogenous male group, but the risk of metabolic syndrome was not increased in risk allele carriers. 37 In our analysis, we have found no association between carrying FTO rs9939609 risk allele and the onset of metabolic syndrome or its components in men and women from Lower Silesia. In the context of mentioned studies, we can presume that the FTO influence on metabolic disturbances in Polish population is secondary to its influence on adiposity.…”

Section: Discussioncontrasting

confidence: 60%

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

Zdrojowy-Wełna¹,

Bednarek-Tupikowska²,

Zatońska³

et al. 2020

Adv Clin Exp Med

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The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland Abstract Background. Fat mass and obesity-associated gene (FTO) polymorphism remains the strongest known genetic determinant of common obesity. However, its influence depends on ethnicity, and the FTO-mediated predisposition to other metabolic disturbances is questionable.Objectives. The aim of our study was to evaluate the association between FTO rs9939609 polymorphism and metabolic syndrome in a population of Prospective Urban Rural Epidemiology (PURE) study in Poland.Material and methods. We enrolled 1,097 participants of the PURE study (683 women and 414 men) from the Lower Silesian voivodeship. Anthropometrical parameters and blood pressure were measured. Blood samples were taken for an examination of lipid profile and fasting glucose level. Genomic DNA was isolated and FTO polymorphism rs9939609 was genotyped.Results. Male A-allele carriers had significantly higher mean body mass, body mass index (BMI), waistto-hip ratio (WHR), and waist and hip circumferences than men without risk allele. They were also more often diagnosed with obesity on the basis of BMI and central obesity parameters. No such influence was observed in women. There were no significant associations between FTO polymorphism and metabolic syndrome or its components. Conclusions.Our results suggest a sex-specific association between FTO polymorphism and obesity traits. The occurrence of metabolic syndrome or its components was not related with FTO gene variation in our cohort.

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Section: Discussioncontrasting

confidence: 60%

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

Zdrojowy-Wełna¹,

Bednarek-Tupikowska²,

Zatońska³

et al. 2020

Adv Clin Exp Med

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show abstract

“…Finally, in the context of the A allele of the FTO gene (rs1558902) investigated in our study, Ślęzak et al evaluated its influence on polish male patients with metabolic syndrome. Although a strong association of the AA genotype with BMI, WHR, and dyslipidemia (mainly cholesterol and triglyceride levels) was revealed in comparison to healthy controls, the researchers did not confirm the significance of the FTO gene polymorphisms among the risk factors of the metabolic syndrome [26]. All in all, further insight is necessary to elaborate on the FTO gene's role in the mechanism of obesity pathogenesis and metabolic disturbances among psoriatic patients.…”

Section: Discussionmentioning

confidence: 93%

The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis

Kisielnicka

Sobalska‐Kwapis

Purzycka-Bohdan

et al. 2022

IJMS

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There is evidence that the concomitance of psoriasis and obesity may originate from the interplay between multiple genetic pathways and involve gene–gene interactions. The aim of this study was to compare the genetic background related to obesity among psoriatic patients versus healthy controls by means of a Genome-Wide Association Study (GWAS). A total of 972 psoriatic patients and a total of 5878 healthy donors were enrolled in this study. DNA samples were genotyped for over 500,000 single nucleotide polymorphisms (SNPs) using Infinium CoreExome BeadChips (Illumina, San Diego, CA, USA). Statistical analysis identified eleven signals (p < 1 × 10−5) associated with BMI across the study groups and revealed a varying effect size in each sub-cohort. Seven of the alternative alleles (rs1558902 in the FTO gene, rs696574 in the CALCRL gene, as well as rs10968110, rs4551082, rs4609724, rs9320269, and rs2338833,) are associated with increased BMI among all psoriatic patients and four (rs1556519 in the ITLN2 gene, rs12972098 in the AC003006.7 gene, rs12676670 in the PAG1 gene, and rs1321529) are associated with lower BMI. The results of our study may lead to further insights into the understanding of the pathogenesis of obesity among psoriatic patients.

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Association of genetic variants and behavioral factors with the risk of metabolic syndrome in Pakistanis

Bhatti

Rana

2022

Biologia

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Assessment of the FTO gene polymorphisms inmale patients with metabolic syndrome

Abstract: Our results indicate that the genetic variation in the FTO gene might be related to single metabolic disturbances. However, the FTO gene polymorphisms are not associated with the risk of MetS.

Cited by 5 publications

References 24 publications

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

The association between FTO gene polymorphism rs9939609 and obesity is sex-specific in the population of PURE study in Poland

The Analysis of a Genome-Wide Association Study (GWAS) of Overweight and Obesity in Psoriasis

Association of genetic variants and behavioral factors with the risk of metabolic syndrome in Pakistanis

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