Assessment of the Glomerular Filtration Rate in Living and Cadaver Donor Recipients Within 12 Months of Kidney Transplant

Abstract

Background: Among patients with urologic disease, end-stage renal disease (ESRD) have the highest mortality rate. The choice of treatment for patients with ESRD is transplantation. The primary objective of this study was to assess the trend of renal function test in cadaver and living donor groups within a year after the surgery. Method: We included ESRD patients who were admitted to our hospital’s clinic from 2001 to 2014. The glomerular filtration rate (GFR) was the outcome of interest. Results: A total of 381 individuals were included in this study, of whom 246 (64.6%) were males. the mean age was 40.8 years (SD=13.2). In this study, 291 (76.4%) patients received a transplant from a live donor. In the cadaver group, the GFR decreased by 3.8 mL/min (95% confidence interval [CI], 1.2-5.0) per six months, while in the living donor group, it decreased by 1.4 mL/min (95% CI, 0.3–2.5). These trends were not significantly different. The GFR of the living donor group was 0.4 mL/min (95% CI, -1.6-2.3, p=0.72) higher than that of the cadaver donor group per six months, which was not significantly different. The rejection rate was lower in the live donor group (odds ratio=0.54 [95% CI, -0.39-0.74], p<0.001). The rejection rate decreased over the study period by 71% every six months, and this decrease did not significantly differ between the study groups. Conclusions: Although the total GFR in the live donor group was higher, given the higher GFR at the time of surgery in the live donor group, the decrease rate in GFR seemed identical in the study groups.