Assessment of the glucose tolerance test in unselected pregnancy using 75 g glucose load

Abstract

A 75 g oral glucose tolerance test (OGTT) was performed in 618 unselected pregnant Chinese women between 24 and 28 weeks gestation. The glucose response at fasting, 1, 2 and 3 h were studied. At 2 h the glucose level at 2-standard deviation and 4-standard deviation above the mean came very close to the criteria of abnormality suggested by the World Health Organization (WHO): 8.3 mmol/l vs. 8.0 mmol/l for impaired glucose tolerance and 10.8 mmol/l vs. 11.0 mmol/l for gestational diabetes mellitus. The area under the glucose response curve also correlates best with the glucose levels at 2 h during the OGTT (y = 2.1x + 4.6, r = 0.885). The 75-g OGTT interpreted with the WHO criteria seems appropriate for pregnant Chinese women. The 75-g test has the added advantages of reducing administration cost and discomfort of the patients.

Nausea and Vomiting of Pregnancy

“…Furthermore, work by Vallacott et al reveals that 50% of affected women believe their work efficiency to be significantly reduced [105]. …”

Gestational diabetes mellitus and its complications

“…It was proposed that the upper limits of normal for plasma glucose concentration 2 hours after a 75 g glucose load for the second and third trimesters were 7.5 and 9.6 mmol/L, respectively; these values were based on the rounded‐up 97.5 percentile measurements. Li et al 13 studied the glucose response of 75 g OGTT in 618 unselected pregnant Chinese women between 24 and 28 weeks gestation. It was found that the 2 hour glucose levels at 2‐standard deviation and 4‐standard deviation above the mean came very close to the criteria of abnormality suggested by WHO: 8.3 mmol/L and 10.8 mmol/L, respectively.…”

Long‐Term Prognosis of Women with Abnormal Glucose Tolerance in Pregnancy

“…Since 1986, the 2 teaching hospitals of the University of Hong Kong (Tsan Yuk Hospital and Kwong Wah Hospital) have adopted the 75 g OGTT and a modified WHO criteria (table 1) to diagnose gestational diabetes, following earlier studies conducted in the same unit to evaluate the 75 g OGTT (7,8).…”

“…A11 women with a random serum glucose value over 5.0 mmol/L more than 2 hours after meal, or over 5. 8 mmol/L within 2 hours of a meal were tested with a 75 g OGTT.…”