Assessment of the haematological profile of children with malaria parasitaemia treated with three different artemisinin-based combination therapies

Chukwuocha, Uchechukwu Madukaku; Chimezie, Onyirioha Misherk; Nwakwuo, Geoffrey Chima; Hope, Okorie; Simplicius, Dozie Ikechukwu Nosike

doi:10.1016/s2222-1808(15)60813-1

Cited by 6 publications

(7 citation statements)

References 32 publications

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“…Study conducted on two groups; Group 1 (UM): 100 children with uncomplicated (mean age 8.83 ± 4.20 years) falciparum malaria and Group 2 (SM): 100 children with severe falciparum malaria (mean age 8.63 ± 3.40 years). Similar studies were reported from different endemic areas in Africa (23)(24)(25).…”

Section: Discussionsupporting

confidence: 88%

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Mohamedahmed¹,

Nour²,

Abakar³

et al. 2020

World J. Adv. Res. Rev.

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Malaria remains one of the most significant global public health challenges, with more than 200 million clinical cases worldwide each year. Falciparum malaria accounting for up to 87.6 % of malaria cases in Sudan. Platelets abnormalities as thrombocytopenia especially severe thrombocytopenia have been associated with mortality in patients with P. falciparum infection. The aim of this study was to study the relationships between thrombocytopenia and their severity with falciparum malaria severity, parasitemia and parasite count. This study was case-control hospital based study conducted among 200 Sudanese children admitted to Wad Medani Pediatric Hospital, Wad Medani, Sudan during period September to December 2018. The study population was divided into two groups. Group 1 (UM) was 100 children with uncomplicated falciparum malaria. Group 2 (SM) was 100 children with severe falciparum malaria were diagnosed by WHO criteria. A 2.5 ml venous blood sample was collected from each children. The malaria parasitemia was determined from thick blood films using plus system. The parasite count (% of parasitized red cells counting) was counted from thin blood film. Platelets count was determined using the Sysmex XP 300 N automated hematology analyzer (Sysmex, Kobe, Japan) and confirmed and assessed using stained thin blood film. The data were analyzed using SPSS software (V 20.0) and Stat disk software (V 13.0). The mean age and male:

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Section: Discussionsupporting

confidence: 88%

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Mohamedahmed¹,

Nour²,

Abakar³

et al. 2020

World J. Adv. Res. Rev.

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“…Study in Sudan showed that malaria infection was higher in male more than female [20]. Similar previous studies were reported from different African countries [21,22,23].…”

Section: Discussionsupporting

confidence: 85%

“…Similar studies observed platelets count were lower among severe than in mild cases (Gerardin et al, 2002;Arévalo-Herrera et al, 2015). In contrast study done in Ethiopia observed no differences in platelets count according to malaria severity [22]. There were significant differences in platelet count and PCT between malaria parasitemia (P value 0.000 and 0.000 respectively).…”

Section: Discussionmentioning

confidence: 56%

Impact of Sever Plasmodium falciparum infection on Platelets Parameters among Sudanese children Living in Al-Jazira State

Mohamedahmed¹,

Ahmed²,

Nour³

et al. 2020

IJCBR

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Background: Falciparum malaria remains one of the most global infection among children particularly in communities with poor resources. Falciparum malaria associated with several hematological changes that affect the major blood cell lines such as platelets lead to platelets parameters (platelets count and indices) abnormalities. Objectives: The aim of this study was to evaluate the effects of falciparum malaria on platelets parameters (platelets count and indices) among Sudanese children. In addition to study relationships and correlation between platelets parameters and malaria parasitemia and parasite count. Materials and Methods: A case control study was conducted in Wad Medani Pediatric Hospital in collaboration with Faculty of Medical laboratory Sciences, University of Gezira, Sudan among 100 children with severe falciparum malaria (mean age 8.63 ± 3.40 years; 61% males), 100 children with uncomplicated falciparum malaria (mean age 8.83 ± 4.20 years; 45% males) and 100 children with normal healthy children controls (mean age 10.08 ± 3.58 years; 50% males). Parasitemia and parasite count (%) was determined directly from thick and thin blood films respectively. The platelets parameters (platelets count and indices) measured by using Sysmex XP 300 N automated analyzer, and platelets count was confirmed and assessed using stained thin blood film. SPSS software (V 20.0) and Stat disk software (V 13.0) were used for data analysis. Results: 72 % of severe falciparum malaria (SM) have hyperparasitemia, while 18 % among uncomplicated falciparum malaria (UM). The thrombocytopenia account for 43 % (SM: 30.5 %; UM: 12.5 %), low PCT account for 35.5 % (SM: 27 %; UM: 8.5 %) and high PDW account for 46.5 % (SM: 23.5 %; UM: 23 %) in falciparum malaria cases. The mean PLTs count and PDW were statistically significantly differences between falciparum malaria cases and normal healthy control (P value 0.000 and 0.008 respectively). The mean PLTs count and PCT in severe falciparum malaria cases were lower than uncomplicated falciparum malaria cases (P value 0.005 and 0.000 respectively). The PLTs count and PCT had significant negative correlation within malaria parasitemia (P value 0.000; r -0.286; P value 0.004; r -0.205 respectively) and malaria parasite count (P value 0.000; r -0.450; P value 0.000; r -0.270 respectively). Conclusion: The study concluded that thrombocytopenia, low PCT and high PDW were observed as most platelets parameters changes in falciparum malaria. PLTs count along with PCT to be recommended as hematological diagnostic markers and prognostic tool to assess the disease severity and to improve the management of falciparum malaria among patients.

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“…Several researchers (Ajayi et al, 2012;Donkor, 2016;Osonwa et al, 2017;Madukaku et al, 2015) have reported similar findings that haemoglobin concentrations were not significantly different from the parasite control treated groups. Conversely, higher concentration of haemoglobin witnessed in the test animals compared to that of Group 3 mice (positive control) agreed with other reports (Ekaidem and Akpan, 2016;Parker et al, 2016).…”

Section: Discussionmentioning

confidence: 77%

Malaria parasite clearance rate of crude methanol extract of Cryptolepis sanguinolenta in mice infected with chloroquine sensitive strain of Plasmodium berghei

Eze¹,

Attama²,

Ibezim³

et al. 2018

J. Med. Plants Res.

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This study aims to determine the malaria parasite clearance rate of crude methanol extract of Cryptolepis sanguinolenta in mice infected with chloroquine sensitive strain of Plasmodium berghei. P. berghei was injected in mice and left for 3 days for establishment. Blood sample collected and diluted with phosphate buffer saline was used for infection. Five (5) groups of animals (mice) were used in this study each containing 5 animals each. The body weights of the entire animal were recorded before and after treatment. Group 1 (normal control), Group 2 (positive control, untreated malaria-passaged mice), Group 3 (standard control, malaria -passaged mice treated with 25 mg/kg body weight of chloroquine), Group 4 (malaria-passaged mice treated with 200 mg/kg body weight of extract), and Group 5 (malariapassaged mice treated with 400 mg/kg body weight of extract). Hematological assessments were carried out before the experiment, 5 days after infection and after treatment. The percentage of parasite load in malaria passaged mice was found to be significantly (p < 0.05) lower in animals treated with mid and high doses of the extract when compared to control groups. Before treatment, no significant (p > 0.05) elevation was observed in the body weight of mice. On day 5 after infection, dose-dependent significant (p < 0.05) decrease was observed in the test groups. After treatment period, the body weights of the animals exhibited dose-dependent increase. The study thus revealed that Cryptolepis sanguinolenta root extracts possesses antimalarial activity in the in vivo mice model and has the ability of re-establishing the blood cells by boosting and stabilizing the blood parameters.

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Assessment of the haematological profile of children with malaria parasitaemia treated with three different artemisinin-based combination therapies

Cited by 6 publications

References 32 publications

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Diagnostic and prognostic value of thrombocytopenia severity in Sudanese children with Falciparum malaria

Impact of Sever Plasmodium falciparum infection on Platelets Parameters among Sudanese children Living in Al-Jazira State

Malaria parasite clearance rate of crude methanol extract of Cryptolepis sanguinolenta in mice infected with chloroquine sensitive strain of Plasmodium berghei

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