Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

He, Yonghan; Zhang, Yunxia; Yang, Libin; Liao, X Q; Zhang, Qingying; Cai, Wan; Kong, Qing Peng

doi:10.1111/jgs.12895

Cited by 12 publications

(9 citation statements)

References 9 publications

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“…IL1R2 ) up-regulated. Taken together, these observations seem to be in well agreement with the ability of centenarians in suppressing or escaping the age-related diseases [ 7 , 12 , 31 ].…”

Section: Discussionsupporting

confidence: 81%

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

Xiao

et al. 2015

PLoS ONE

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It is recognized that genetic factors contribute to human longevity. Besides the hypothesis of existence of longevity genes, another suggests that a lower frequency of risk alleles decreases the incidence of age-related diseases in the long-lived people. However, the latter finds no support from recent genetic studies. Considering the crucial role of epigenetic modification in gene regulation, we then hypothesize that suppressing disease-related genes in longevity individuals is likely achieved by epigenetic modification, e.g. DNA methylation. To test this hypothesis, we investigated the genome-wide methylation profile in 4 Chinese female centenarians and 4 middle-aged controls using methyl-DNA immunoprecipitation sequencing. 626 differentially methylated regions (DMRs) were observed between both groups. Interestingly, genes with these DMRs were enriched in age-related diseases, including type-2 diabetes, cardiovascular disease, stroke and Alzheimer’s disease. This pattern remains rather stable after including methylomes of two white individuals. Further analyses suggest that the observed DMRs likely have functional roles in regulating disease-associated gene expressions, with some genes [e.g. caspase 3 (CASP3)] being down-regulated whereas the others [i.e. interleukin 1 receptor, type 2 (IL1R2)] up-regulated. Therefore, our study suggests that suppressing the disease-related genes via epigenetic modification is an important contributor to human longevity.

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“…IL1R2 ) up-regulated. Taken together, these observations seem to be in well agreement with the ability of centenarians in suppressing or escaping the age-related diseases [ 7 , 12 , 31 ].…”

Section: Discussionsupporting

confidence: 81%

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

Xiao

et al. 2015

PLoS ONE

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“…All of the longevity subjects had no severe life-threatening illness, such as heart attack, cerebellar hemorrhage, and cancer, according to the medical examination. Only some of them had decreased vision or hearing loss as reported previously ( He et al, 2014 , Ye et al, 2009 ). The control subjects were all healthy with no severe medical history.…”

Section: Methodssupporting

confidence: 72%

The reduction of vascular disease risk mutations contributes to longevity in the Chinese population

He¹,

Lü²,

et al. 2014

Meta Gene

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AimGenetic factors play important roles in determining human lifespan. Although some “longevity genes” have been identified to be implicated in human longevity, many disease-associated variants were also observed in the long-lived individuals. The oldest old and their offspring usually have a lower prevalence of age-related diseases, which is likely attributed to a reduction or an absence of disease risk variants.Methods and resultsTo test this hypothesis, 23 disease risk single nucleotide polymorphisms (SNPs), identified by previous genome-wide association studies (GWASs), were selected and genotyped in 1074 samples consisting of 574 longevity subjects (over 90 years old) and 500 younger controls. Our results revealed that 5 SNPs (rs2144300, rs1864163, rs2200733, rs1967017, and rs7193343) displayed significantly lower allelic frequencies and odds ratios (ORs) in the longevity group than that in the control group. The frequencies of homozygous mutation genotypes and corresponding ORs of the rs1864163, rs2200733, rs127430, rs1967017, and rs12413409 were lower in the longevity subjects. Interestingly, most of the abovementioned SNPs convey susceptibility to cardiovascular disease (CVD), which is the leading cause of deaths in old adults but shows a much lower incidence in the longevity individuals and their offspring.ConclusionTaking into account the observation that the longevity subjects and their offspring have lower rate of cardiovascular mortality, it is then most plausible that the lack of disease risk variants, especially the CVD, is a genetic contributor to longevity in the Chinese population.

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“…Forty families each contained at least one centenarian, one F1 offspring, and one spouse of the offspring, who were used to test the genetic correlations. The health status of centenarians has been investigated previously; here the relationship between thyroid function and longevity was focused on. Serum thyroid‐stimulating hormone (TSH), triiodothyronine (T3), and thyroxine (T4) are three main thyroid function parameters; TSH regulates the production of T3 and T4, and T3 or T4 negatively regulate TSH through a negative feedback mechanism.…”

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confidence: 99%

Thyroid Function Decreases with Age and May Contribute to Longevity in Chinese Centenarians’ Families

Chen

Yan

et al. 2015

J American Geriatrics Society

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Assessment of the Health Status of Centenarians in the South of China: A Cross‐Sectional Study

Cited by 12 publications

References 9 publications

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

A Genome-Wide Scan Reveals Important Roles of DNA Methylation in Human Longevity by Regulating Age-Related Disease Genes

The reduction of vascular disease risk mutations contributes to longevity in the Chinese population

Thyroid Function Decreases with Age and May Contribute to Longevity in Chinese Centenarians’ Families

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