Assessment of the<i>E-Selectin</i>rs5361 (561A&gt;C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Sandoval-Pinto, Elena; Padilla-Gutiérrez, Jorge Ramón; Valdés-Alvarado, Emmanuel; García-González, Ilian Janet; Valdez-Haro, Angélica; Muñoz‐Valle, José Francisco; Flores-Salinas, Héctor Enrique; Rivas, Fernando; Valle, Yeminia

doi:10.1155/2014/158367

Cited by 7 publications

(3 citation statements)

References 63 publications

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“…13,14 The high level of sE-selectin observed in both diabetic groups compared with controls may be due to endothelial activation and inflammation in response to hyperglycemia; this activation and inflammation may occur regardless the presence or absence of CVDs. 15 In 2014, Sandoval-Pinto et al 16 evaluated serum levels of sE-selectin in 283 patients with acute coronary syndrome (ACS) and compared them with levels in 205 healthy subjects. They found that sEselectin levels were significantly higher in ACS patients compared with controls (54.58 versus 40.41 ng/ml, p ¼ 0.02).…”

Section: Discussionmentioning

confidence: 99%

Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

et al. 2019

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Objective Type 2 diabetes mellitus (T2DM) is a main risk factor for development of cardiovascular diseases (CVDs) and endothelial dysfunction. This study aimed to investigate serum levels of soluble vascular cell adhesion molecule 1 (sVCAM-1), intercellular adhesion molecule 1 (sICAM-1), and endothelium selectin (sE-selectin) in T2DM patients with macrovascular complications. Methods A cross-sectional study of 21 controls, 30 T2DM patients without CVDs, and 30 T2DM patients with CVDs was conducted. Serum levels of soluble adhesion molecules including sVCAM-1, sICAM-1, and sE-selectin were determined using ELISA. Results Serum levels of sVCAM-1, sICAM-1, and sE-selectin were higher in T2DM patients than in controls. Levels of serum sVCAM-1 were higher in T2DM patients with CVDs compared with T2DM patients without CVDs. In T2DM patients with CVDs, significant positive associations were observed between sVCAM-1, sICAM-1, and sE-selectin levels (r = 0.575, p = 0.001 and r = 0.378, p = 0.040). Conclusions Circulating levels of soluble adhesion molecules were elevated in T2DM patients, regardless of whether the patients had cardiovascular complications. Only sVCAM-1 was considered a useful marker for the prediction of CVDs in T2DM patients.

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Section: Discussionmentioning

confidence: 99%

Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

et al. 2019

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“…However, after correcting E-selectin for gender, no difference was found for these levels in the HIV-infected group compared to the controls, and males still had higher E-selectin levels regardless of their HIV status. Both the significance of age and gender has been demonstrated in various other studies 50–52. After the age of forty, the risk of CVD is increased by up to 49% in males and 32% in females, with males being 3.4 times more susceptible due to their naturally higher expression of E-selectin 50.…”

Section: Discussionmentioning

confidence: 89%

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals

Hoffman¹,

Ipp²,

Phatlhane³

et al. 2018

Afr H. Sci.

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BackgroundE-selectin has been shown to play a role in atherosclerosis and to be increased in HIV-infected individuals due to chronic immune activation. There is a paucity of studies on E-selectin in HIV-infected treatment-naïve individuals.ObjectivesThis study aimed to determine whether E-selectin levels were increased in HIV-infected treatment-naïve individuals and whether these correlated with markers of disease severity, inflammation and coagulation to determine if this population is at risk for cardiovascular disease (CVD).MethodsE-selectin levels were determined in 114 HIV-infected treatment-naive and 66 HIV-negative individuals, compared between groups and correlated with markers of disease severity, inflammation and coagulation.ResultsThere were statistically significant differences (p<0.01) in levels of WCC, CD4+ count, %CD38/8, albumin, IgG, hsCRP and D-dimer between groups and no statistically significant differences in E-selectin (p=0.84) and fibrinogen (p=0.65) levels. E-selectin correlated with age (p=0.02) and gender (p=0.01).ConclusionE-selectin was a poor marker in this setting. There was no correlation with any of the markers of disease severity, inflammation and coagulation. E-selectin is most likely raised in an acute inflammatory setting, rather than chronic stage of HIV-infection. We recommend that other markers be utilized to identify patients at increased risk of CVD; as these were significantly increased untreated in individuals.

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“…SELE (Selectin E) is an endothelial cell-specific surface protein involved in leukocyte attachment to endothelial cells. Previously, genetic variants of SELE were strongly associated with cardiovascular disease [ 35 , 36 , 37 , 38 ]. Interestingly, increased levels of soluble endothelial markers, including SELE, and endothelial dysfunction have been co-observed in AF patients [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Integrated Analysis of the microRNA–mRNA Network Predicts Potential Regulators of Atrial Fibrillation in Humans

Wang

Bektik

Sakon

et al. 2022

Cells

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Atrial fibrillation (AF) is a form of sustained cardiac arrhythmia and microRNAs (miRs) play crucial roles in the pathophysiology of AF. To identify novel miR–mRNA pairs, we performed RNA-seq from atrial biopsies of persistent AF patients and non-AF patients with normal sinus rhythm (SR). Differentially expressed miRs (11 down and 9 up) and mRNAs (95 up and 82 down) were identified and hierarchically clustered in a heat map. Subsequently, GO, KEGG, and GSEA analyses were run to identify deregulated pathways. Then, miR targets were predicted in the miRDB database, and a regulatory network of negatively correlated miR–mRNA pairs was constructed using Cytoscape. To select potential candidate genes from GSEA analysis, the top-50 enriched genes in GSEA were overlaid with predicted targets of differentially deregulated miRs. Further, the protein–protein interaction (PPI) network of enriched genes in GSEA was constructed, and subsequently, GO and canonical pathway analyses were run for genes in the PPI network. Our analyses showed that TNF-α, p53, EMT, and SYDECAN1 signaling were among the highly affected pathways in AF samples. SDC-1 (SYNDECAN-1) was the top-enriched gene in p53, EMT, and SYDECAN1 signaling. Consistently, SDC-1 mRNA and protein levels were significantly higher in atrial samples of AF patients. Among negatively correlated miRs, miR-302b-3p was experimentally validated to suppress SDC-1 transcript levels. Overall, our results suggested that the miR-302b-3p/SDC-1 axis may be involved in the pathogenesis of AF.

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Assessment of theE-Selectinrs5361 (561A>C) Polymorphism and Soluble Protein Concentration in Acute Coronary Syndrome: Association with Circulating Levels

Cited by 7 publications

References 63 publications

Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

Levels of soluble cell adhesion molecules in type 2 diabetes mellitus patients with macrovascular complications

E-Selectin and markers of HIV disease severity, inflammation and coagulation in HIV-infected treatment-naïve individuals

Integrated Analysis of the microRNA–mRNA Network Predicts Potential Regulators of Atrial Fibrillation in Humans

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