2018
DOI: 10.1016/j.etap.2018.05.013
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Assessment of the inhibitory activity of the pyrethroid pesticide deltamethrin against human placental glutathione transferase P1-1: A combined kinetic and docking study

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Cited by 9 publications
(9 citation statements)
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“…For these reasons, they hypothesized that the prominent role of elevated GSTs in conferring resistance in N. lugens is through protecting tissues from oxidative damage. Markus et al also elucidated the inhibitory activity of deltamethrin against human GST [ 49 ]. They proved that deltamethrin was a potent inhibitor of GST-P1-1, and it inhibited the homodimeric enzyme in a non-competitive manner.…”
Section: Discussionmentioning
confidence: 99%
“…For these reasons, they hypothesized that the prominent role of elevated GSTs in conferring resistance in N. lugens is through protecting tissues from oxidative damage. Markus et al also elucidated the inhibitory activity of deltamethrin against human GST [ 49 ]. They proved that deltamethrin was a potent inhibitor of GST-P1-1, and it inhibited the homodimeric enzyme in a non-competitive manner.…”
Section: Discussionmentioning
confidence: 99%
“…Pi-class glutathione-S-transferase (GSTP1) is a cytosolic homodimeric protein with two subunits, each with its active site (GSH binding site and an electrophilic substrate binding site, with molecular weights of 22 and 30 kDa, respectively). This enzyme is encoded by the GSTP1 gene located on the long arm of chromosome 11 (11q13), with a length of approximately 2.84 kb [2,33]. It acts in the detoxification of xenobiotics and as an antioxidant by inactivating harmful and carcinogenic electrophiles [32,33,36].…”
Section: Genes Involved In the Metabolism Of Xenobioticsmentioning
confidence: 99%
“…It acts in the detoxification of xenobiotics and as an antioxidant by inactivating harmful and carcinogenic electrophiles [32,33,36]. In addition, it can inhibit apoptosis by inactivating JNK1 (c-Jun N-terminal kinase-1), thus preventing H 2 O 2induced apoptosis [2,32]. However, there are genetic variants (SNP) that can directly affect the functionality of GSTP1, for example, the rs1695 polymorphism has a downstream change in one base of exon 5 at position 313, from adenine to guanine, leading to a change from isoleucine to valine (ATC to GTC) at position 105 (Ile105Val).…”
Section: Genes Involved In the Metabolism Of Xenobioticsmentioning
confidence: 99%
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