The aim of the study is to establish the actual level of working loads on the roll drive line of the sizing mill installed as part of the PRP-220 with an automatic mill, when switching to the production of steel pipes from increased strength group. The study is based on a complex experimental and theoretical analysis. After the processing of the results of experimental studies a comparison of the most loaded sizing route for a thin-walled pipe with a diameter of 244.5 mm and a wall thickness of 8.9 mm (D/S = 27.5) made of steel of strength group “D” was made with the route for a pipe with a diameter of 177.8 mm and a wall thickness of 9.2 mm (D/S = 19.3) from steel of strength group “E”. Graphs of the observed processes are presented, as well as calculated predictive values of sizing of thin-walled pipes for steel of strength group “E”, obtained on the basis of an experimental-theoretical analysis of the growth of flow stress. Recommendations have been given for improving the equipment of the PRP-220 sizing mill for the production of pipes with increased diameters from steels of increased strength groups.