Assessment of the Lung Toxicity of Copper Oxide Nanoparticles: Current Status

Ahamed, Maqusood; Akhtar, Mohd Javed; Alhadlaq, Hisham A.; Alrokayan, Salman A.

doi:10.2217/nnm.15.72

Cited by 106 publications

(85 citation statements)

References 80 publications

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“…The extensive damage to the integrity of the murine lung by CuO may be due to the oxidative stress caused by Cu via the Fenton reaction, since it is a transition metal (Karlsson et al, 2013). The dissolution of Cu ions from CuO may also be a contributing factor to the lung injury observed in the mice after instillation of CuO (Ahamed et al 2015). It is worth noting that for the PEPs, in addition to LDH and MPO, levels of hemoglobin and albumin, inflammatory cellular response, gene expression, and chemo-/cytokine secretion were measured in the BALF of BALB/c mice 24 h after intratracheal instillation of 0.5, 2.5 and 5 mg/kg of PEPs (Pirela et al, 2015b).…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, exposure to PEPs upregulated expression of the Ccl5 (Rantes) , Nos1 and Ucp2 genes in the murine lung tissue, which are involved in both the repair process from oxidative damage and the initiation of immune responses to foreign pathogens. For CuO nanoparticles, there is evidence on their ability to cause lung injury, severe neutrophilic inflammation, and neoplastic lesions in lung as summarized in in vivo toxicological assessment studies reviewed in Ahamed et al (2015).…”

Section: Discussionmentioning

confidence: 99%

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In vivoepigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

Miousse

Pirela

et al. 2015

Nanotoxicology

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Evidence continues to grow on potential environmental health hazards associated with engineered nanomaterials (ENMs). While the geno- and cytotoxic effects of ENMs have been investigated, their potential to target the epigenome remains largely unknown. The aim of this study is twofold: 1) determining whether or not industry relevant ENMs can affect the epigenome in vivo; and 2) validating a recently developed in vitro epigenetic screening platform for inhaled ENMs. Laser printer-emitted engineered nanoparticles (PEPs) released from nano-enabled toners during consumer use and copper oxide (CuO) were chosen since these particles induced significant epigenetic changes in a recent in vitro companion study. In this study, the epigenetic alterations in lung tissue, alveolar macrophages, and peripheral blood from intratracheally instilled mice were evaluated. The methylation of global DNA and transposable elements (TEs), the expression of the DNA methylation machinery and TEs, in addition to general toxicological effects in the lung were assessed. CuO exhibited higher cell-damaging potential to the lung, while PEPs showed a greater ability to target the epigenome. Alterations in the methylation status of global DNA and TEs, and expression of TEs and DNA machinery in mouse lung were observed after exposure to CuO and PEPs. Additionally, epigenetic changes were detected in the peripheral blood after PEPs exposure. Altogether, CuO and PEPs can induce epigenetic alterations in a mouse experimental model, which in turn confirms that the recently developed in vitro epigenetic platform using macrophage and epithelial cell lines can be successfully utilized in the epigenetic screening of ENMs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

In vivoepigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

Miousse

Pirela

et al. 2015

Nanotoxicology

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“…The uptake of TiO 2 NPs led to a dose dependent increase in autophagic effect under non cytotoxic conditions, which has been demonstrated in Lopes's research [40]. Leaching of Cu ions, reactive oxygen species generation and autophagy appear to be the underlying mechanisms of Cu NP toxicity in lung cells [41]. Lu proposes that Lipid Nanoparticles (LNs) induce autophagy lysosome signaling and neurovascular response at least partially via an Atg5 dependent pathway [42].…”

Section: Autophagy and Nanomaterialsmentioning

confidence: 87%

The Role of Cell Autophagy in Toxicity Caused by Dental Nanomaterials

Wei¹

2017

NTMB

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NanomaterialsThe overview of nanomaterials Nanomaterials are defined as materials composed of unbound particles or particles in an aggregate or agglomerate state with one or more external dimensions with a size ranging from 1nm to 100nm [1]. Nanomaterials have a lot of free surfaces and interfaces and there is interaction between the various units. Based on the above characteristics, nanomaterials are featured by surface effect, small size effect, quantum size effect, macroscopic quantum tunneling effect and the dielectric confinement effect. Nanoparticles have lots of unpaired atoms, large specific surface area, less surface defects and can occur in conjunction with the polymer stronger physically or chemically. Added to the polymer material, they can improve the ductility, toughness, strength, barrier properties, heat resistance and dimensional stability of the material. They have been widely used in conventional materials, medical equipment, electronic equipment, paint and other industries. However, nanomaterials will affect the organism and produce a series of toxic effects by inducing oxidative stress and inflammatory response mechanisms in the cell, subcellular and protein levels. The nanomaterials commonly used in dentistryNanometer materials are widely applied in the field of dentistry, including dental restoration, antibacterial, caries treatment, orthodontic, root canal, bonding systems and so on.Adding nanoparticles to dental restoration materials to improve the performance has been widely used in the clinical field. In view of its unpaired atoms, large specific surface area, less surface defects and occurring in conjunction with the polymer either stronger physically or chemically, the novel resin composite exhibited a strong antibacterial property upon the addition of up to 5% nano antibacterial inorganic fillers, there by leading to effective caries inhibition in dental application [2]. The mesoporous silica biomaterials have great potential for serving as both a catalyst and carrier in the repair or regeneration of dental hard tissue [3]. Diatomite-based nanocomposite ceramics are good potential candidates for ceramic-based dental materials [4]. Nano silicon dioxide can also give polymers the characteristics of better viscosity, thermal stability, high strength, less volume shrinkage and of course, durability [5].In clinical endodontics especially root canal and restorative treatments we can see the near future potential of nanoparticles from the application of nanoparticles in the form of solutions for irrigation, medication and as an additive within sealers/restorative materials [6]. GICs can be applied to base plates of Orthodontic and modified denture base well, as which contain chlorhexidine hexametaphosphate nanoparticles and characterize the nanoparticle size shows a stronger antimicrobial activity [7].As for caries treatment, Hannig M said that Analysis of in vitro data indicates that apatite nanoparticles might be effective in reversing lesion progression in the outer but not in the deepe...

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“…Generally, the toxicities of TiO 2 and CeO 2 nanoparticles are low [1]- [3]. On the contrary, ZnO, NiO, and CuO nanoparticles have demonstrated toxicity in cultured cells and animals [4]- [6]. Further, the physical and chemical properties of nanoparticles can influence the toxicity [7] [8].…”

Section: Introductionmentioning

confidence: 99%

Metal Ion Release of Manufactured Metal Oxide Nanoparticles Is Involved in the Allergic Response to Inhaled Ovalbumin in Mice

Horie¹,

Stowe²,

Tabei³

et al. 2016

ODEM

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The aim of the present study was to establish the mechanism of the allergy aggravation effect. Our previous study showed that soluble ZnO nanoparticles caused allergy aggravation, but insoluble TiO2 and SiO2 nanoparticles did not induce an allergic response. Metal ion release is associated with the cytotoxicity of manufactured nanoparticles; however, the role of metal ion release in allergy aggravation remains to be elucidated. Therefore, we examined the allergy aggravation potential of several soluble manufactured nanoparticles (ZnO, CuO, NiO, MgO, and CaCO3). These nanoparticles were administered to mouse lungs by pharyngeal aspiration and subsequently, the mice inhaled ovalbumin (OVA). We also compared the properties of soluble NiO nanoparticles with insoluble micro-scale NiO particles. NiO nanoparticles markedly increased the levels of OVAspecific immunoglobulin (Ig) E but micro-scale NiO particles did not. Among the nanoparticles (ZnO, CuO, MgO, and CaCO3), ZnO induced increase of OVA-specific IgE level. CuO showed tendency to increase OVA-specific IgE; however, no significant difference was observed. Additionally, ZnO and NiO nanoparticles enhanced expression of a gene related to inflammation (Cxcl2), heavy metal detox (metallothionein 2), and oxidative stress (heme oxygenase-1). Gene expression of arginase1, which is enhanced by T helper 2 cytokine, was remarkably enhanced in mice administered ZnO and NiO particles. These effects were not observed in mice administered MgO and CaCO3 nanoparticles. In conclusion, the solubility and type of metal ion released from the nanoparticles influence * Corresponding author. M. Horie et al. 18the allergy aggravation effect. The results showed that the release of Zn 2+ and Ni 2+ aggravated the allergic reaction.

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Assessment of the Lung Toxicity of Copper Oxide Nanoparticles: Current Status

Cited by 106 publications

References 80 publications

In vivoepigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

In vivoepigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles

The Role of Cell Autophagy in Toxicity Caused by Dental Nanomaterials

Metal Ion Release of Manufactured Metal Oxide Nanoparticles Is Involved in the Allergic Response to Inhaled Ovalbumin in Mice

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