Assessment of the peripheral immunocompetent cells in patients with reticular and atrophic-erosive lichen planus

Type and Portions of Peripheral Blood T Lymphocytes in Oral Lichen Planus

“…They showed no significant difference between the patients and the control group in the level of CD3+, CD4+, CD8+ and CD4+/CD8+. Moreover, the results of our study confirmed the study of Lin et al (10), Walton et al (11), Krasowska et al (12) and Charazinska et al (9). On the other hand, Carrozzo et al (8) showed the decreased level of CD4+ and CD4+/CD8+ and increased level of CD8+ in patients; however, they used different statistical tests (t-test, Mann-Whitney U test, and Kruskal-Wallis test).…”

Declined hTERT expression of peripheral blood CD4+ T cells in oral lichen planus correlated with clinical parameter

“…Importantly, Yang et al observed that the length of telomeres and telomerase activity of naïve T cells were significantly decreased in patients with MDS, whereas memory T cells did not differ in this respect, which confirmed that a deficiency in telomerase selectively affecting naïve T cells and explained the skewed naïve‐to‐memory CD4 + T‐cell ratios in patients with MDS . Consistent with our results, an assessment of the peripheral immunocompetent cells in patients with OLP exhibited significantly decreased CD4 + naïve helper T cells, increased memory cells, and skewed naïve‐to‐memory CD4 + T‐cell ratios . Thus, presumably, the abnormal hTERT of CD4 + may participate in the pathogenesis of OLP through inducing altered lymphocyte homeostasis from a decreased naïve T‐cell compartment and the accumulation of senescent cells.…”

Histologic and systemic prognosticators for local control and survival in margin‐negative transoral laser microsurgery treated oral cavity squamous cell carcinoma

“…The causes were autoimmune diseases ( n = 4; 2 patients each with systemic lupus erythematosus and lichen planus, 20 all 4 patients were administered immuno-suppressant drugs), Hodgkin lymphoma ( n = 2; of which 1 patient had whole body irradiation), immunoglobulin M and A deficiency ( n = 1), history of chemoradiation for breast cancer 22 ( n = 1), acquired immunodeficiency syndrome ( n = 1), and chronic debilitating illness ( n = 2; 1 patient with poorly controlled diabetes 23 and 1 patient with diabetes and cirrhosis). 24 The presence of immune compromise correlated significantly with disease recurrences ( p = .039).…”

“…History of intrinsic, iatrogenic, or chronic conditions that are documented in the literature [20][21][22][23][24] to cause immune compromise (eg, autoimmune disease, intake of immunosuppressant drugs, lymphoreticular disorders, history of chemoradiation, immunodeficiencies, and chronic debilitating illness) were recorded retrospectively from the medical records.…”