Assessment of the pharmacological effects of alprazolam on electroencephalography using connectivity indexes not affected by volume conduction

López, Joan Francesc Alonso; Camps, Aitana Sabater; Lafuente, Sergio Romero; Villanueva, Miguel Ángel Mañanas; Serrano, Jordi Riba

doi:10.3389/conf.fnsys.2015.06.00008

Cited by 1 publication

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“…In line with our findings, Arnts and colleagues observed a decrease in beta band functional connectivity (AECc) throughout the brain in patients with severe brain injury after administration of zolpidem ( Arnts et al, 2020 ). Again, in line with our study, previous research using the PLI found no effect of benzodiazepines in the beta band in healthy controls ( Alonso López et al, 2015 ) or patients scheduled for a gastrointestinal endoscopic procedure ( Numan et al, 2019 ). These findings suggest that benzodiazepines affect beta band amplitude coupling but not phase-coupling.…”

Section: Discussionsupporting

confidence: 92%

Associations between psychotropic drugs and rsEEG connectivity and network characteristics: a cross-sectional study in hospital-admitted psychiatric patients

Zandstra,

Meijs,

Somers

et al. 2023

Front. Neurosci.

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IntroductionResting-state EEG (rsEEG) characteristics, such as functional connectivity and network topology, are studied as potential biomarkers in psychiatric research. However, the presence of psychopharmacological treatment in study participants poses a potential confounding factor in biomarker research. To address this concern, our study aims to explore the impact of both single and multi-class psychotropic treatments on aforementioned rsEEG characteristics in a psychiatric population.MethodsRsEEG was analyzed in a real-world cross-sectional sample of 900 hospital-admitted psychiatric patients. Patients were clustered into eight psychopharmacological groups: unmedicated, single-class treatment with antipsychotics (AP), antidepressants (AD) or benzodiazepines (BDZ), and multi-class combinations of these treatments. To assess the associations between psychotropic treatments and the macroscale rsEEG characteristics mentioned above, we employed a general linear model with post-hoc tests. Additionally, Spearman’s rank correlation analyses were performed to explore potential dosage effects.ResultsCompared to unmedicated patients, single-class use of AD was associated with lower functional connectivity in the delta band, while AP was associated with lower functional connectivity in both the delta and alpha bands. Single-class use of BDZ was associated with widespread rsEEG differences, including lower functional connectivity across frequency bands and a different network topology within the beta band relative to unmedicated patients. All of the multi-class groups showed associations with functional connectivity or topology measures, but effects were most pronounced for concomitant use of all three classes of psychotropics. Differences were not only observed in comparison with unmedicated patients, but were also evident in comparisons between single-class, multi-class, and single/multi-class groups. Importantly, multi-class associations with rsEEG characteristics were found even in the absence of single-class associations, suggesting potential cumulative or interaction effects of different classes of psychotropics. Dosage correlations were only found for antipsychotics.ConclusionOur exploratory, cross-sectional study suggests small but significant associations between single and multi-class use of antidepressants, antipsychotics and benzodiazepines and macroscale rsEEG functional connectivity and network topology characteristics. These findings highlight the importance of considering the effects of specific psychotropics, as well as their interactions, when investigating rsEEG biomarkers in a medicated psychiatric population.

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Section: Discussionsupporting

confidence: 92%