Assessment of the relationship between the amount of scorpion venom in the central nervous system and the severity of scorpion envenomation in rats

Laaradia, Mehdi Ait; Oufquir, Sara; Hidan, Moulay Abdelmonaim El; Marhoume, Fatimazahra; Laadraoui, Jawad; Bezza, Kenza; Gabbas, Zineb El; Aboufatima, Rachida; Boumezzough, Ali; Chait, Abderrahman

doi:10.1080/15569543.2019.1573198

Cited by 2 publications

(1 citation statement)

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“…In previous studies, Ozkan et al 27 showed that Iurus dufoureius asiaticus venom was responsible for salivation, humpback, paralysis, excitability, weakness and coma. Ait Laaradia et al 28 revealed severe symptoms by the Morrocan Buthus lienhardi scorpion venom represented by dyspnea, hypersalivation, chewing, mouth rubbing, rotating behavior, convulsions and a little scream, which were all dose-dependent. The Tityus bahiensis venom (2.5 mg/kg) also induced moderate manifestations of increased respiratory and salivary frequency, increased sensitivity and vocalization to touch, as well as rigidity in hind limbs.…”

Section: Discussionmentioning

confidence: 99%

Induced pathophysiological alterations by the venoms of the most dangerous Moroccan scorpions Androctonus mauretanicus and Buthus occitanus: A comparative pathophysiological and toxic-symptoms study

et al. 2022

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Scorpion envenomation is a serious public health issue. Androctonus mauretanicus ( Am) and Buthus occitanus ( Bo) are the most dangerous scorpions in Morocco. Despite their medical relevance, no study has yet related their kinetics of symptom apparition and the consequent tissue disorders at the same interval post-injection. This work achieved the first comparative pathophysiological and toxic-symptoms study between the Am and Bo venoms from a biochemical, toxicological and physiopathological standpoint. The activity of venoms and their subletal dose were determined by administration of increasing concentrations of the venoms. 30, 60 and 120 min following the experimental envenomation in mice, the profile of clinical symptoms was underlined and the main organs: brain, heart, lungs, liver and kidneys were removed for histological examination. The Am venom is a rich source of proteins and three-times more toxic than the Bo. The most observed clinical symptoms are neurological and cardiopulmonary. The Am venom caused histopathological alterations at 30, 60, and 120 min which were more important than the Bo. This study highlighted that both venoms exhibited a strong toxicity with variable intensities. Moreover, we showed the presence of correlation between the level of histopathological disorders observed and the intensity of signs appeared at the same time following venom inoculation.

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Section: Discussionmentioning

confidence: 99%