Background: Emergency physicians (EPs) are exposed to various stressors that lead to burnout, and these factors have never been examined in the emergency departments (EDs) of the Kingdom of Bahrain. The study identifies the prevalence rates and associated variables for burnout and stress among EPs in Bahrain’s EDs.Methods: A cross sectional study involving 134 EPs working in the ED for the three major tertiary hospitals completed the Copenhagen Burnout Inventory (CBI) and Stress Overload Scale-Short Form (SOS-S).Results: The survey had a response rate of 86.7% (n=116). The prevalence rate was 81.0% for personal burnout (M: 63.0, SD: 22.4; CI: 67.0% - 83.3%), 69.8% for work-related burnout (M: 60.3, SD: 21.6; CI: 60.6%- 78.0%), and 40.5% for patient-related burnout (M: 43.1, SD: 25.4; CI: 31.5% - 50.0%). Approximately 23.9% EPs were at high risk for illness. The CBI and SOS-S subscales had statistically significant correlations, illustrating that higher personal, work-related, and patient-related burnout was associated with higher personal vulnerability, event load, and stress overload. Being female, Bahraini, Chief Resident or Consultant, working >50 hours per week, taking at least one sick leave in the last year, and experiencing sleep disturbances and workplace violence were all contributing factors to higher burnout and stress levels. Conclusion: The prevalence of burnout and stress among the EPs in Bahrain is high and reflects a significant problem. Several demographic and occupational factors are closely related to burnout and stress, and need to be addressed to higher authorities in order to implement protective measures.