Assessment of the relationship between core body temperature and QT/QTc in the minipig using Dihydrocapsaicin

Confounding Factors in the Interpretation of Preclinical Studies

“…9,10 They confirmed this finding examining the diurnal changes in BT and QTc and by treating the animals with dihydrocapsaicin, another agent shown to lower BT. 11 Aside from drug-induced changes in BT, most of the literature examples focus on how environmental temperature affects biological responses. Although the mouse is the most common model studied under these conditions, there is one particularly interesting finding from a Novartis primate toxicology study testing a dipeptidyl peptidase (DPP) 4 inhibitor.…”

“…9,10 They confirmed this finding examining the diurnal changes in BT and QTc and by treating the animals with dihydrocapsaicin, another agent shown to lower BT. 11…”