Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction

Kim, Bo Young; Kim, Sung‐Soo; Park, Hyeong Kyu; Kim, Hyun‐Sook

doi:10.1177/0300060519897701

Cited by 8 publications

(8 citation statements)

References 31 publications

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“…According to earlier research, there is no connection between the cohort of patients undergoing arthroscopic meniscal surgery and current or past smoking [ 38 ]. In contrast to our study’s findings, several researchers found that smoking increased the risk of total knee replacement surgery in women [ 39 ]. Another study came to the same conclusion as ours: Smoking does not affect the development of OA.…”

Section: Discussioncontrasting

confidence: 99%

An evaluation of knee osteoarthritis pain in the general community—Asir region, Saudi Arabia

Kandasamy,

Almaghaslah,

Almanasef

et al. 2024

PLoS ONE

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Background Knee osteoarthritis (KOA) is one of the most common conditions resulting in disability, particularly in the elderly population. Osteoarthritis (OA) is the most common articular disease and the leading cause of chronic disability in the developed world. Objective This study was carried out to evaluate knee pain in the Asir region of Saudi Arabia. An analytical cross-sectional survey design was adopted in the Asir region from April 2023 to August 2023 to assess the knee pain of the adult population using an anonymous online questionnaire. Results Of 1234, 332 were men (26.90) and 902 were women (73.09). WOMAC index score category 55.34% (n = 683) of the subjects had a low risk (score <60), 28.68% (n = 354) had a moderate risk (score 60–80), and 15.96% (n = 197) had a high risk (score ≥81) for KOA. According to clinical criteria, 79.33% (n = 979) of the study subjects had OA. Age group, gender 2.17 (1. 67–2.82) [OR 2.17; 95% CI 1.67–2.82), family history of OA [OR 0.47; 95% CI 0.37–0.62], diabetes [OR 2.78; 95% CI 2.17–3.56], hypertension [OR 0.35; 95% CI 0.26–0.45] were significantly associated with the percentage of the WOMAC index score using the Chi-square test analysis (P<0.05). Therefore, the WOMAC index showed higher diagnostic precision with a statistically significant association [OR 9.31 CI 6.90–12.81] with a P< 0.0001. Conclusion KOA is more common in older, obese people who have reached the age of 50 in the Asir region, and it is more prevalent in women. Alarms the need for appropriate awareness programs for better disease prevention and health outcomes for the benefit of the community through general public health programs.

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Section: Discussioncontrasting

confidence: 99%

An evaluation of knee osteoarthritis pain in the general community—Asir region, Saudi Arabia

Kandasamy,

Almaghaslah,

Almanasef

et al. 2024

PLoS ONE

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“…In a study, a relationship between musculoskeletal ultrasound abnormalities, knee pain and thyroid dysfunction was found. 15 Similar to our study, this study shows that thyroid function disorders worsen OA symptoms. In some studies, high TSH levels have been shown to increase the synovial fluid amount and viscosity by increasing the synthesis of hyaluronic acid and proteoglycans.…”

Section: Discussionsupporting

confidence: 89%

Effect of Thyroid Dysfunctions on Pain and Physical Function in Patients with Gonarthrosis

Gezgınaslan¹,

Başar²,

Atalay³

2022

J PMR Sci

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This study aims to investigate the effects of thyroid dysfunction on pain and physical function in patients with gonarthrosis. Material and Methods: A total of 82 patients with the diagnosis of Grade 1-3 gonarthrosis according to the Kellgren-Lawrence (K/L) radiographic grading system were included. Patients were divided into 2 groups. Group 1 (n=41) included gonarthrosis patients with thyroid dysfunctions, Group 2 (n=41) included gonarthrosis patients with normal thyroid functions. Visual analog scale (VAS) and The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) subscale scores were compared between the groups. Results: There was no statistically significant difference in age, knee symptom duration, VAS, WOMAC-Pain, WOMAC-Stiffness and K/L scores between groups. The WOMAC-Physical Function score was significantly higher in Group 1 (p<0.05). Conclusion: Physical function level may be lower in gonarthrosis patients with thyroid dysfunction than in patients with gonarthrosis alone. It may be useful for physical function, to treat thyroid dysfunction in patients with gonarthrosis who apply to outpatient clinics.

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“…T3 could stimulate the synthesis of collagen X and the expression of matrix metalloproteinase 13 (MMP-13) and alkaline phosphatase, and promoted the progress of MMP-13, ultimately leading to cartilage mineralization and degradation [25][26][27]. Kim et al indicated that both hypothyroid and hyperthyroid states were associated with the incidence of knee arthralgia and knee osteoarthritis [10]. According to Devrimsel et al, patients with hypothyroidism had thinner femurs and a higher risk of OA than healthy individuals at all measurement sites [28].…”

Section: Discussionmentioning

confidence: 99%

“…Although the etiology and pathogenesis of OA have not yet been fully clarified, aging, obesity, infection, trauma, and metabolic disorders are considered risk factors for OA [7,8]. Recent studies have demonstrated the important role of thyroid hormone metabolism in articular cartilage maintenance and the pathogenesis of OA [9][10][11]. Thyroid hormone is essential for endochondral ossification and the expression of genes that control chondrocyte maturation and matrix synthesis [12].…”

Section: Open Accessmentioning

confidence: 99%

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

et al. 2022

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Objectives Thyroid hormones play an instrumental role in chondrogenic differentiation and matrix maturation. However, studies investigating the relationship between thyroid function and the risk of osteoarthritis (OA) remain scarce. This study was designed to investigate the correlation between thyroid status and OA from a novel perspective of sensitivity to thyroid hormones. Methods The study included 8478 people from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. The sensitivity to thyroid hormone indices included Thyrotroph Thyroxine Resistance Index (TT4RI), Thyroid-stimulating hormone (TSHI), Thyroid Feedback Quantile-based Index (TFQI), and Free Triiodothyronine /Free thyroxine (FT3/FT4), which were calculated based on serum free triiodothyronine (FT3), free thyroxine (FT4), and thyroid stimulating hormone (TSH). Considering the complex survey design and sample weights, we employed multivariate linear regression models and stratified analysis to evaluate the correlation between sensitivity to thyroid hormone indices and OA. Results Study results indicated that participants with OA had elevated TT4RI, TSHI, and TFQI levels, and lower FT3/FT4 levels compared to those with non-arthritis. After adjusting for other covariates, FT3/FT4 was negatively associated with the risk of OA (OR = 1.162, 95%CI 1.048–1.478, P = 0.021); (OR = 1.261, 95%CI 1.078–1.623, P = 0.042). In subgroup analyses stratified by gender and BMI, participants with OA had higher TFQI levels compared to those without OA in both genders. (OR = 1.491, 95%CI 1.070–2.077, P = 0.018); (OR = 2.548, 95%CI 1.929–3.365, P < 0.001). The higher TFQI levels were consistently associated with the increased prevalence of OA in the BMI (< 18.5 kg/m2) group after adjusting for different covariates, but not in other BMI groups. In, addition, TFQI performed better than FT3/FT4, TSHI, and TT4RI on ROC analyses for OA prediction. Conclusions The levels of FT3/FT4, TSHI, TT4RI, and TFQI are strongly associated with the prevalence of OA, which illustrates the complex correlation between the thyroid system and chondrogenic differentiation. TFQI may be used as a helpful indicator to predict OA and provide novel ideas for the evaluation and treatment of OA.

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Assessment of the relationship between knee ultrasound and clinical symptoms in patients with thyroid dysfunction

Cited by 8 publications

References 31 publications

An evaluation of knee osteoarthritis pain in the general community—Asir region, Saudi Arabia

An evaluation of knee osteoarthritis pain in the general community—Asir region, Saudi Arabia

Effect of Thyroid Dysfunctions on Pain and Physical Function in Patients with Gonarthrosis

Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study

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