Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Gu, Zhen-Jie; Yang, Yuanyuan; Zhang, Lingyu; Chen, Cong

doi:10.20452/pamw.15598

Cited by 8 publications

(10 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It was reported in the literature that 98% of the cases present with reduced LVEF [ 25 ]. A meta-analysis including three cohort studies with a total of 70,697 participants reported a 17% increase in the overall risk of incident HF in people with osteoporosis compared with those without [ 26 ]. In their subgroup analysis, the Asian populations with osteoporosis had a higher risk of incident HF.…”

Section: Discussionmentioning

confidence: 99%

Hypocalcemia Is a Common Risk Factor for Osteoporosis in Taiwanese Patients with Cushing’s Syndrome

Chen

Tsai

Chen

et al. 2022

IJERPH

View full text Add to dashboard Cite

Background: Osteoporosis is a cardinal manifestation of Cushing’s syndrome. There is a lack of relevant research on risk factors for osteoporosis among patients with Cushing’s syndrome (CS) in Taiwan. Thus, this study was designed to explore the possible risk factors of osteoporosis. Methods: We gathered patients with a diagnosis of CS between 2001 and 2017 in the Chang Gung Research Database (CGRD). We extracted data including diagnoses and biochemistry from hospital records. The diagnosis of CS was based on ICD-9-CM codes (255.0). Osteoporosis was defined by a T value equal to or less than −2.5 in BMD examination and hypocalcemia was defined as serum calcium concentrations < 8.0 mg/dL. Results: A total of 356 patients with CS who made regular visits to the outpatient department were enrolled in this study. The mean age was 68.6 years, and 74.9% of the patients were female. Of them, 207 patients (58.1%) were diagnosed with osteoporosis. Multivariable logistic regression models indicated that serum calcium level was negatively associated with osteoporosis (OR 0.70, CI 0.54–0.91, p < 0.001) after adjustment for age, sex, and other confounding risk factors. In addition, hypocalcemia was associated with heart failure (HF) (OR 2.14, CI 1.02–4.47, p < 0.05), stroke (OR 2.58, CI 1.21–5.46, p < 0.05) and osteoporosis (OR 3.04, CI 1.24–7.41, p < 0.05) in multivariate analysis. Conclusions: Our study found that lower serum calcium levels were common among patients with CS and osteoporosis. Furthermore, CS patients with HF or stroke had high proportion of hypocalcemia. Therefore, these patients must pay more attention to adequate calcium supplementation and undergo the appropriate osteoporosis drug treatment to reduce the risk of subsequent fracture and disability.

show abstract

Section: Discussionmentioning

confidence: 99%

Hypocalcemia Is a Common Risk Factor for Osteoporosis in Taiwanese Patients with Cushing’s Syndrome

Chen

Tsai

Chen

et al. 2022

IJERPH

View full text Add to dashboard Cite

show abstract

“…The reduction of total cholesterol (TC) and LDL-C in preventing CVD events is supported by increasing scientific evidence [ 6 , 7 ]. Recently, CVD has been related to other concomitant pathologies such as osteoporosis and diabetes; moreover, these diseases share some risk factors including age, lifestyle (sedentarity, unhealthy diet, smoking, alcohol abuse), drug exposures (e.g., systemic glucocorticoids), and hypovitaminosis D [ 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Preliminary Results of CitraVes™ Effects on Low Density Lipoprotein Cholesterol and Waist Circumference in Healthy Subjects after 12 Weeks: A Pilot Open-Label Study

et al. 2021

View full text Add to dashboard Cite

Appropriate monitoring and control of modifiable risk factors, such as the level of low-density lipoprotein cholesterol (LDL-C) and other types of dyslipidemia, have an important role in the prevention of cardiovascular diseases (CVD). Recently, various nutraceuticals with lipid-lowering effects have gained attention. In addition to the plant-derived bioactive compounds, recent studies suggested that plant cells are able to release small lipoproteic structures named extracellular vesicles (EVs). The interaction between EVs and mammalian cells could lead to beneficial effects through anti-inflammatory and antioxidant activities. The present study aimed to assess the safety of the new patented plant-based product citraVes™, containing extracellular vesicles (EVs) from Citrus limon (L.) Osbeck juice, and to investigate its ability to modulate different CV risk factors in healthy subjects. A cohort of 20 healthy volunteers was recruited in a prospective open-label study. All participants received the supplement in a spray-dried formulation at a stable dose of 1000 mg/day for 3 months. Anthropometric and hematobiochemical parameters were analyzed at the baseline and after the follow-up period of 1 and 3 months. We observed that the supplement has an effect on two key factors of cardiometabolic risk in healthy subjects. A significant change in waist circumference was found in women after 4 (85.4 [79.9, 91.0] cm, p < 0.005) and 12 (85.0 [80.0, 90.0] cm, p < 0.0005) weeks, when compared to the baseline value (87.6 [81.7, 93.6] cm). No difference was found in men (baseline: 100.3 [95.4, 105.2] cm; 4 weeks: 102.0 [95.7, 108.3] cm; 12 weeks: 100.0 [95.3, 104.7] cm). The level of LDL-C was significantly lower at 12 weeks versus 4 weeks (p = 0.0064). Our study evaluated, for the first time, the effects of a natural product containing plant-derived EVs on modifiable risk factors in healthy volunteers. The results support the use of EV extracts to manage cardiometabolic risk factors successfully.

show abstract

“…Despite progress in therapy for chronic heart failure (CHF) and increased recognition of its clinical risk factors, the prevalence of CHF continues to rise and has reached the proportions of a pandemic [1]. Therefore, it is very important to recognize all the factors that may potentially affect the course of CHF, in order to prevent its exacerbation and reduce the need for hospitalization [1,2]. One of multiple such factors seems to be patients' nutritional status [1][2][3][4][5][6], and especially that the provision of nutritional support can improve the outcomes of patients with CHF [7].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, it is very important to recognize all the factors that may potentially affect the course of CHF, in order to prevent its exacerbation and reduce the need for hospitalization [1,2]. One of multiple such factors seems to be patients' nutritional status [1][2][3][4][5][6], and especially that the provision of nutritional support can improve the outcomes of patients with CHF [7]. In CHF patients, assessing nutritional status on the basis of anthropometric parameters is not reliable, i.a.…”

Section: Introductionmentioning

confidence: 99%

Nutritional status and body composition of patients hospitalized due to exacerbated heart failure

Wawrzeńczyk¹,

Kowalczyk²,

Szukay³

et al. 2021

Polish Archives of Internal Medicine

View full text Add to dashboard Cite

Assessment of the risk of incident heart failure in osteoporosis patients: a systematic review and meta-analysis of eligible cohort studies

Cited by 8 publications

References 44 publications

Hypocalcemia Is a Common Risk Factor for Osteoporosis in Taiwanese Patients with Cushing’s Syndrome

Hypocalcemia Is a Common Risk Factor for Osteoporosis in Taiwanese Patients with Cushing’s Syndrome

Preliminary Results of CitraVes™ Effects on Low Density Lipoprotein Cholesterol and Waist Circumference in Healthy Subjects after 12 Weeks: A Pilot Open-Label Study

Nutritional status and body composition of patients hospitalized due to exacerbated heart failure

Contact Info

Product

Resources

About