Assessment of the Risk of Type 2 Diabetes Among Healthy Without Diabetes in Sudan Using the Findrisc Tool

Osman, Osman Abdalrhman; Saeed, Ali Awadallah; Mousnad, Mohamed Awad; Hamid, Azza Abd El

doi:10.22270/ujpr.v5i4.438

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…The leaves of C. abyssinica have been shown to contain saccharopine [(2S, 2′S)-N6-(2glutaryl) lysine], 2-aminoadipic acid and severalglutamyl peptides 15 . The aim of this study was to assess the quality (types), quantity (amount), and antidiabetic potential of the methanolic extract of C. abyssinica leaves in diabetic rats 16 .…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antidiabetic Activity of Methanolic Extract of Caylusea Abyssinica Leaves

Al-Kaf

O²,

N³

et al. 2023

Univ J Pharm Res

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Introduction: Controlling type 2 diabetes with a treatment having no side effects remains a challenge for researchers even if the side effects are reduced and there may be a chance for reduced adverse reactions or severe side effects due to drug interaction. These interactions could result from concurrent use of dietary supplements or pharmacological therapy in addition to the medications. The current reading's objective was to assess the qualitative and quantitative phytochemical analyses, and antidiabetic potentials of methanol leaf extract of Caylusea abyssinica (C. abyssinica) in diabetic rats. Methods: The qualitative and quantitative phytochemical analyses of total alkaloids phenol, and flavonoids were determined using the well-known test procedure outlined in the literature. The obtained C. abyssinica methanol leaf extract was used to examine in vitro anti-diabetic activity (α-Amylase inhibition), oral acute toxicity, and in vivo anti-diabetic activity against streptozotocin-induced diabetes rat model. Alkaloids, carbohydrates, reducing sugars, saponins, phenolic compounds, glycosides, tannins, and flavonoids were all established in the samples after phytochemical examination. Results: The amount of phenolics in the methanol leaf extract was (295.50 mg/g), with flavonoids coming in second (136.66 mg/g) and alkaloids coming in third (11.23 mg/g). The extract's ability to inhibit α-amylase was investigated. The study's findings show that the chosen plants had significant in vitro anti-diabetic effect. Up to 2000 mg/kg given over 14 days, the methanol extract's acute toxicity trials did not reveal any harmful effects. Rats were given streptozotocin (60 mg/kg; i.p.) to induce diabetes, and glibenclamide (500 mcg/kg body weight) was utilized as the usual medication. Body weight, HDL, total protein, SGOT, SGPT, cholesterol, blood sugar levels, and triglycerides were all assessed in this study. Comparing diabetic rats to normal (control) rats, blood sugar and total protein, SGOT, SGPT, cholesterol levels, and triglyceride concentrations were all considerably (p< 0.001) reduced after oral administration of methanol extract of C. abyssinica at doses of 100 and 200 mg/kg and increased the level of HDL and body weight. Conclusion: As a result of the aforementioned findings, it can be said that C. abyssinica methanol leaf extract significantly reduces blood sugar levels in streptozotocin-induced diabetic rats. Peer Review History: Received: 5 November 2022; Revised: 11 December; Accepted: 8 January 2023, Available online: 15 January 2023 Academic Editor: Dr. Tamer Elhabibi, Suez Canal University, Egypt, tamer_hassan@pharm.suez.edu.eg Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.0/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Dr. Sangeetha Arullappan, Universiti Tunku Abdul Rahman, Malaysia, sangeetha@utar.edu.my Prof. Hüsniye Kayalar, Ege University, Turkey, husniyekayalar@gmail.com Similar Articles: EFFECT OF THE AQUEOUS EXTRACT OF CLERODENDRUM THOMSONIAE LINN (VERBENACEAE) LEAVES ON TYPE 2 DIABETIC WISTAR RATS INDUCED BY THE MACAPOS1 TYPE DIET AND DEXAMETHASONE ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF DRACAENA CINNABARI BALF. RESIN ETHANOLIC EXTRACT OF SOQATRA ISLAND IN EXPERIMENTAL ANIMALS EVALUATION OF METHANOLIC EXTRACT OF EUPHORBIA NERIIFOLIA STEM BARK ON BLOOD SUGAR LEVELS, SERUM AND TISSUE LIPIDS IN A PRECLINICAL MODEL

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Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antidiabetic Activity of Methanolic Extract of Caylusea Abyssinica Leaves

Al-Kaf

O²,

N³

et al. 2023

Univ J Pharm Res

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Is the FINDRISC Tool Useful in Screening Type 2 Diabetes and Metabolic Syndrome in an African Setting? Experience among Young Adults in Urban Tanzania

et al. 2021

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Background: Simple and less costly screening tools are needed to combat the rising non-communicable diseases epidemic. This study aimed to evaluate the utility of The Finnish Diabetes Risk Score (FINDRISC) as a screening tool for prediabetes, T2D, and metabolic syndrome (MetS) in a population of young adults in urban Mwanza, Tanzania. Methods: A cross-sectional community-based study was conducted among participants aged 18–35 years. The FINDRISC questionnaire was used to collect data and compute the FINDRISC scores for each participant. Socio-demographic, anthropometric, blood glucose, and lipid profiles data were collected accordingly. Results: A total of 259 participants were recruited into the study. The median age was 21 years (IQR 19–27), and more than half 60.2% (156) were females. In total, 32.8% (85) of the participants had at least a slightly elevated risk of developing T2D in 10 years’ time. Compared to the Oral Glucose Tolerance Test (OGTT), FINDRISC had a sensitivity and specificity of 39.1% and 69.2%, respectively (aROC = 0.5). The FINDRISC score significantly correlated with MetS (p = 0.001). Conclusion: In this study, FINDRISC has shown low sensitivity and specificity in the screening of pre-diabetes/T2D. However, it has potential utility in the screening of MetS in a young-adult population.

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Assessment of the Risk of Type 2 Diabetes Among Healthy Without Diabetes in Sudan Using the Findrisc Tool

Cited by 2 publications

References 8 publications

Phytochemical Screening and Antidiabetic Activity of Methanolic Extract of Caylusea Abyssinica Leaves

Phytochemical Screening and Antidiabetic Activity of Methanolic Extract of Caylusea Abyssinica Leaves

Is the FINDRISC Tool Useful in Screening Type 2 Diabetes and Metabolic Syndrome in an African Setting? Experience among Young Adults in Urban Tanzania

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