Assessment of the Safety and Efficacy of the Chinese Herbal Formula (CHF) in Fracture Treatment

Yuan, Ziying

doi:10.1145/3535694.3535721

Cited by 1 publication

(2 citation statements)

References 15 publications

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“…According to TKM and TCM theories, the pathological symptoms of fractures are accompanied by redness, pain, and swelling at the fracture site, which may cause circulatory congestion or delay treatment [65]. Studies examining TKM and TCM suggest that herbal medicines can improve fracture healing by controlling inflammation, promoting blood circulation, and stimulating bone formation [66].…”

Section: Discussionmentioning

confidence: 99%

“…Fracture healing is a complex process involving various factors at the cellular and molecular levels and can lead to various complications, such as delayed healing or nonunion healing pattern [63]. These complications are difficult to treat and result in a financial burden owing to the loss of productivity [66]. Accordingly, any strategy that helps reduce the healing time aids in the rapid resumption of work duties and daily activities by the patients, improvement of their medical outcomes, and reduction of their financial burden.…”

Section: Cpmp Safetymentioning

confidence: 99%

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Therapeutic Efficacy of Chinese Patent Medicine Containing Pyrite for Fractures: A Systematic Review and Meta-Analysis

Nam,

Choi,

Hwang

2023

Medicina

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Background and Objectives: Korean and traditional Chinese medicine state that pyrite is effective for fracture treatment, but supporting clinical data are limited. This systematic review aimed to investigate the therapeutic role of Chinese patent medicine containing pyrite (CPMP) in clinical treatment for fractures. Materials and Methods: Seven electronic databases were searched using the keywords “pyrite”, “pyritum”, and “zirantong” between inception and December 2022, yielding 29 published clinical studies. Randomized controlled trials that included CPMP were considered eligible regardless of the fracture type. Quality assessment and meta-analysis of the included RCTs were also performed. Results: Most studies showed high heterogeneity (I2 > 50%) and significant results (p < 0.05). Compared to the results of the control group, CPMP was more effective in terms of the primary outcome related to the efficacy rate, including the total effective rate, callus growth rate, bone union, and edema disappearance time (all p < 0.00001) and in terms of secondary outcomes related to pain reduction, namely pain intensity and pain disappearance time, than the control group (both p < 0.01). CPMP was more effective than the control group in terms of erythrocyte sedimentation rate (p < 0.01), hematocrit (p < 0.01), erythrocyte aggregation (p < 0.05), and plasma viscosity (p < 0.05). CPMP did not cause serious side effects, and the incidence of complications was significantly less than that in the control group. Conclusions: CPMP may be a safe and effective alternative treatment for fractures and may be beneficial in preventing postoperative complications, reducing pain, relieving symptoms, and accelerating healing.

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Section: Discussionmentioning

confidence: 99%

Section: Cpmp Safetymentioning

confidence: 99%