Assessment of the tolerance dose of the hepatic reticulo-endothelial system (RES) after single fraction HDR-irradiation: Anin-vivostudy employing SSPIO

Abstract

Hepatic RES demonstrated a high regenerative capacity and a higher minimal threshold dose than hepatocytes. Temporary function loss was found from the 13 Gy isosurface.

Narrative Review of High-Dose-Rate Interstitial Brachytherapy in Primary or Secondary Liver Tumors

“…The Offenbach group has reported the results of 31 patients with inoperable primary and secondary liver tumors, treated between 2000 and 2009 with CT-guided interstitial BT (10), while the Magdeburg group introduced a novel catheter implantation technique, which uses a trochar puncture needle, that is exchanged over a stiff angiographic guide wire for a flexible 6-F catheter sheath using Seldinger's technique and the subsequent replacement of the wire by a closed-end 6F BT catheter, and reported their first results back in 2004 (25). It has to be noted that the extended clinical research conducted by Ricke et al (Magdeburg Group), regarding multiple aspects of liver HDR BT, such as organs at risk (OARs) tolerance dose assessment (26)(27)(28)(29), dose and fractionation evaluation (11,30), magnetic resonance imaging (MRI) and positron emission tomography (PET) introduction in guidance and implantation accuracy, treatment planning, as well as tumor/tissue radiation response (29,(31)(32)(33)(34) expanded the knowledge base of the whole brachytherapy community. The first experience regarding the feasibility of MRI-guided liver brachytherapy was published in 2001 by Kettenbach et al (35).…”