Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis

Lagali, Pamela S.; Shanmugalingam, Ushananthini; Baker, Adam N.; Mezey, Natalie; Smith, Patrice D.; Coupland, Stuart G.; Tsilfidis, Catherine

doi:10.1007/s10633-023-09933-y

Doc Ophthalmol

2023

DOI: 10.1007/s10633-023-09933-y

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Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis

Pamela S. Lagali¹,

Ushananthini Shanmugalingam²,

Adam N. Baker³

et al.

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2024

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Anesthetic effects on electrophysiological responses across the visual pathway

Zhang,

Xu,

Liu

et al. 2024

Sci Rep

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Anesthetics are widely used in electrophysiological tests to assess retinal and visual system functions to avoid experimental errors caused by movement and stress in experimental animals. To determine the most suitable anesthetic for visual electrophysiological tests, excluding ketamine and chloral hydrate due to regulatory and side effect concerns, this study investigated the effects of ethyl carbamate (EC), avertin (AR), and pentobarbital sodium (PS) on visual signal conduction in the retina and primary visual cortex. Assessments included flash electroretinogram (FERG), pattern electroretinogram (PERG), pattern visual evoked potentials (PVEP), and flash visual evoked potentials (FVEP), FERG and FVEP were used to evaluate the responses of the retina and visual cortex to flash stimuli, respectively, while PERG and PVEP assessed responses to pattern stimuli. The research showed that AR demonstrates the least disruption to the visual signal pathway, as evidenced by consistently high characteristic peaks in the AR group across various tests. In contrast, mice given EC exhibited the lowest peak values in both FERG and FVEP, while subjects anesthetized with PS showed suppressed oscillatory potentials and PERG responses. Notably, substantial PVEP characteristic peaks were observed only in mice anesthetized with AR. Consequently, among the three anesthetics tested, AR is the most suitable for visual electrophysiological studies.

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Anesthetic effects on electrophysiological responses across the visual pathway

Zhang,

Xu,

Liu

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

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Assessment of the uniform field electroretinogram for mouse retinal ganglion cell functional analysis

Cited by 1 publication

References 54 publications

Anesthetic effects on electrophysiological responses across the visual pathway

Anesthetic effects on electrophysiological responses across the visual pathway

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