Assessment of the use of immunosuppressants combined with cord blood for severe aplastic anemia

Songnuan, Wisuwat; Bunnag, Chaweewan; Soontrapa, Kitipong; Pacharn, Punchama; Wangthan, Unchalee; Siriwattanakul, Umaporn; Malainual, Nat

doi:10.12932/ap0571.33.3.2015

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Because IL-17A is a pro-inflammatory cytokine, its dysregulation is associated with various autoimmune disorders, such as type 1 diabetes, rheumatoid arthritis, and Sjögren’s syndrome 23 – 25 . Furthermore, our data support previous findings that patients with active AA had elevated IL-17 concentrations 15 , 16 , and suggest that IL-17 may also play a role in AA progression. Further analyses revealed a moderate negative correlation between plasma IL-17A concentration and the CD4 + /CD8 + T-cell ratio, and negative correlation between IL-17A concentrations and the patients’ clinical manifestations of AA.…”

Section: Discussionsupporting

confidence: 91%

Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia

Niu¹,

Zhou²,

Liu³

et al. 2017

Sci Rep

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Acquired aplastic anaemia (AA) is caused by T-cells migrating to and attacking bone marrow (BM) in response to chemokines (e.g., CXCR4). We investigated CXCR4 expressions on circulating T-cell subsets, plasma IL-17A concentrations, and their correlations with AA manifestations. We enrolled 71 patients with acquired AA (36 severe AA cases [SAA] and 35 non-severe AA cases [NSAA]) and 42 healthy volunteers. We used flow cytometry and ELISA to measure circulating CD4+ and CD8+ T-cells, their CXCR4 expressions, and plasma IL-17A concentrations. Compared to the healthy controls, SAA patients had fewer peripheral CD4+ T-cells, more CD8+ T-cells, and a significantly decreased CD4+/CD8+ ratio which was positively correlated with AA manifestations. Patients with SAA or NSAA had higher proportions of CD4+CXCR4+ and CD8+CXCR4+ T-cells, which were negatively correlated with haemoglobin concentrations and absolute neutrophil counts. Patients with SAA or NSAA had higher plasma IL-17A concentrations, which were negatively correlated with AA manifestations and the CD4+/CD8+ ratio. IL-17A concentrations showed a very week correlation with CD4+CXCR4+ T-cells frequencies, and no correlation with CD8+CXCR4+ T-cells frequencies. Aberrant CXCR4 expression may allow circulating T-cells, especially CD8+ T-cells, to infiltrate BM during AA progression. Elevated IL-17A concentrations may contribute to AA progression outside of the CXCR4-SDF-1α axis.

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Section: Discussionsupporting

confidence: 91%

Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia

Niu¹,

Zhou²,

Liu³

et al. 2017

Sci Rep

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“…Выявлены современные особенности цикла развития и времени цветения растений, связанные с увеличением глобальной температуры, по сравнению с аналогичными показателями 20-30-летней давности [20] . В Китае пыльца Artemisia Humulus является основным аллергеном осенью и летом, а наиболее высокий уровень ее содержания в воздухе наблюдается между 24 августа и 5 сентября .…”

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“…Распространенность АР у жителей Ханоя значительно выше, чем у проживающих в сельской местности (29,6 и 10,0% соответственно; p<0,001) [16] . При этом наблюдается уменьшение числа пациентов, стращающихся сезонным АР, но увеличивается в 3-4 раза удельный вес пациентов, сенсибилизированных к домашней и промышленной пыли [20] .…”

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Prevalence and etiology of allergic rhinitis in the conditions of North Vietnam the countries of South-East Asia

Kryukov¹,

Бондарева²,

Thảo³

2019

Ross. rinol.

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A Pilot Study to Identify Grass Species That Mediate Pollen Allergy in Thailand

Jarupund,

Jantrakulroj,

Suwanphakdee

et al. 2023

Int Arch Allergy Immunol

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Introduction: Some grass species that are either common or widely spread in Thailand have not been used for pollen allergy diagnosis. In order to improve diagnostic accuracy, the aim of this pilot study was to identify the grass species responsible for pollen allergy in Thailand. Methods: The skin sensitization of pollen extracts from six different grass species, including rice (Oryza sativa), corn (Zea mays), sorghum (Sorghum bicolor), para grass (Urochloa mutica), ruzi grass (Urochloa eminii), and green panic grass (Megathyrsus maximus), was evaluated by skin prick test (SPT). Serum’s IgE specific to each pollen extract was analyzed by Western blot (WB). The ImmunoCAPTM test for Johnson grass was also evaluated. Results: Of the thirty-six volunteers who participated in this study, eighteen tested positive for at least one of the diagnostic tests, namely SPT, WB analysis, or ImmunoCAPTM. Notably, skin reactivity to para grass, corn, sorghum, and rice was more commonly observed compared to ruzi grass and green panic grass. However, in the WB analysis, individuals with pollen-specific IgE were more frequently detected in sorghum, green panic grass, corn, rice, and ruzi grass than para grass. Conclusion: In this pilot investigation, our findings indicate that the pollen extracts of rice, corn, sorghum, and para grass are associated with pollen allergy in Thailand. These results contribute to the current knowledge on the identification of grass species that are associated with pollen allergy in Thailand and Southeast Asia.

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Assessment of the use of immunosuppressants combined with cord blood for severe aplastic anemia

Cited by 5 publications

References 35 publications

Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia

Expression of CXCR4 on T-cell subsets and Plasma IL-17 Concentrations in Patients with Aplastic Anaemia

Prevalence and etiology of allergic rhinitis in the conditions of North Vietnam the countries of South-East Asia

A Pilot Study to Identify Grass Species That Mediate Pollen Allergy in Thailand

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