Assessment of titanium dioxide nanoparticles toxicity via oral exposure in mice: effect of dose and particle size

Ali, Sanaa A.; Rizk, Maha Z.; Hamed, Manal A.; Aboul-Ela, E. I.; El-Rigal, Nagy Saba; Aly, Hanan F.; Abdel-Hamid, Abdel-Hamid Z.

doi:10.1080/1354750x.2019.1620336

Cited by 38 publications

(18 citation statements)

References 45 publications

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“…More specifically, the physicochemical descriptors are both size related and combine the size of the pristine NP core (as measured with electron microscopy) with the NP’s behaviour within a specific medium (hydrodynamic diameter). NP core size was linked with cytotoxicity in the past [ 89 , 90 , 91 , 92 , 93 , 94 ] with decreasing size related to higher toxicity. This was usually in conjunction with the assay parameter of exposure dose, since on a constant mass basis there will be much higher numbers of smaller particles relative to larger ones [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

et al. 2020

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A literature curated dataset containing 24 distinct metal oxide (MexOy) nanoparticles (NPs), including 15 physicochemical, structural and assay-related descriptors, was enriched with 62 atomistic computational descriptors and exploited to produce a robust and validated in silico model for prediction of NP cytotoxicity. The model can be used to predict the cytotoxicity (cell viability) of MexOy NPs based on the colorimetric lactate dehydrogenase (LDH) assay and the luminometric adenosine triphosphate (ATP) assay, both of which quantify irreversible cell membrane damage. Out of the 77 total descriptors used, 7 were identified as being significant for induction of cytotoxicity by MexOy NPs. These were NP core size, hydrodynamic size, assay type, exposure dose, the energy of the MexOy conduction band (EC), the coordination number of the metal atoms on the NP surface (Avg. C.N. Me atoms surface) and the average force vector surface normal component of all metal atoms (v⊥ Me atoms surface). The significance and effect of these descriptors is discussed to demonstrate their direct correlation with cytotoxicity. The produced model has been made publicly available by the Horizon 2020 (H2020) NanoSolveIT project and will be added to the project’s Integrated Approach to Testing and Assessment (IATA).

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Section: Resultsmentioning

confidence: 99%

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

et al. 2020

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“…AgNPs are categorized at nanoscale, to possess unique physicochemical properties that make them dissipate from their bulk particles (Ali et al., 2019; Loeschner et al., 2011). Nevertheless, particle size may be the principle factor affecting the toxicity of AgNPs.…”

Section: Discussionmentioning

confidence: 99%

“…Further, histopathological examination in the present study showed the presence of different incidences of lesions in the hepatic tissue of intoxicated AgNPs groups which might be due to ROS generation. Besides, high reactivity and easy transportability into the liver cell may lead to such high toxicity for small NPs than large size silver nanoparticles (Ali et al., 2019; Cho et al., 2018).…”

Section: Discussionmentioning

confidence: 99%

“…After one week of acclimatization, animals were randomly divided into seven groups (10 animals each) according to the following: Group 1: Control group. Groups from 2 to 4: Animals were given AgNPs size 20 nm (100 mg/kg) 2.5 mg/mice dissolved in 1 ml of H 2 O (Elkhawass et al., 2015) for 1 month; 5 days/week (Ali et al., 2019) then the following regimen was applied: Group 2: AgNPs intoxicated animals. Group 3: Intoxicated animals were treated with C. edulis leaves extract (500 mg/kg) 12.5mg per mice dissolved in 1 ml H 2 O for three weeks (Aly et al., 2018). Group 4: Intoxicated animals were treated with G. pentaphylla leaves extracts (500 mg/kg) for 3 weeks (De et al., 2017).…”

Section: Methodsmentioning

confidence: 99%

“…Groups from 2 to 4: Animals were given AgNPs size 20 nm (100 mg/kg) 2.5 mg/mice dissolved in 1 ml of H 2 O (Elkhawass et al, 2015) for 1 month; 5 days/week (Ali et al, 2019) then the following regimen was applied:…”

Section: Animal Groupings and Treatmentsmentioning

confidence: 99%

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DNA damage and genetic aberration induced via different sized silver nanoparticles: Therapeutic approaches of Casimiroa edulis and Glycosmis pentaphylla leaves extracts

et al. 2020

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Potential of Casimiroa edulis and Glycosmis pentaphylla leaves extracts were investigated against the effect of two different particle sizes of silver nanoparticles induced toxicity in mice. Mice received silver nanoparticles (AgNPs) (100 mg/kg) with 20 and 100 nm for four weeks followed by daily oral dose of extracts (500 mg/kg) for three weeks. C. edulis leaves identified fourteen phenolic compounds while, G. pentaphylla leaves identified, twelve phenolic compounds. Additionally, biochemical, genotoxicity, mutagenicity, and histopathological investigations were carried out, revealed that liver function activities, lipid profile, hydrogen peroxide, and C-reactive protein were significantly elevate post AgNPs exposure. While, superoxide dismutase, glutathione-S-transferases, and glutathione peroxidase significantly reduce. A marked amelioration in all detected biomarkers, improved histopathological changes and repair DNA damage after treated with C. edulis and G. pentaphylla leaves extracts. These extracts are used for the first time as promising candidate therapeutic agents against toxicity induced by AgNPs. Practical applications The potential applications of AgNPs make it necessary to investigate the possible toxicity associated with release of free silver ions in the biological system. AgNPs of varying particle sizes had toxic effects as evidenced by alterations in some cellular biochemical parameters, genotoxicity, mutagenicity, and histopathological indices on mice. Casimiroa edulis and Glycosmis pentaphylla leaves extracts are used for the first time as promising candidate therapeutic, where they are able to ameliorate the toxicity induced via AgNPs and record vacillate percentage of improvement in the selected biomarkers, as a result of the bioactive secondary metabolites especially flavonoids and other polyphenolic compounds.

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Toxicity of Metallic Nanoparticles

Mehta¹,

Parikh²,

Hariharan³

et al. 2021

Nanotechnology in Medicine

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Assessment of titanium dioxide nanoparticles toxicity via oral exposure in mice: effect of dose and particle size

Cited by 38 publications

References 45 publications

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

Predicting Cytotoxicity of Metal Oxide Nanoparticles Using Isalos Analytics Platform

DNA damage and genetic aberration induced via different sized silver nanoparticles: Therapeutic approaches of Casimiroa edulis and Glycosmis pentaphylla leaves extracts

Toxicity of Metallic Nanoparticles

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