Assessment of total polyphenols, flavonoids and anti-inflammatory potential of three Apiaceae species grown in the Southeast of Morocco

Derouich, Mgal; Bouhlali, Eimad dine Tariq; Hmidani, Abdelbassat; Bammou, Mohammed; Bourkhis, Bouchra; Sellam, Khalid; Alem, Chakib

doi:10.1016/j.sciaf.2020.e00507

Cited by 25 publications

(20 citation statements)

References 26 publications

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“…Anti-inflammatory study of a polyphenol-rich extract of Petroselinum crispum (Mill.) Fuss, Apium graveolens L. and Coriandrum sativum L. showed 50 % inhibition of protein denaturation at 118, 227 and 247 µg/ml concentrations, respectively (62). Comparing those IC50 values with PLE depicted the better efficacy of polyphenolic fraction of leaf extract of L. quinqueflora as an anti-inflammatory agent.…”

Section: Anti-inflammatory Assay: Inhibition Of Protein Denaturationmentioning

confidence: 90%

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

Jose¹,

Anilkumar²

2021

Plant Sci. Today

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The main aim of the work was to scientifically prove the anti-inflammatory property of the polyphenol-rich fraction of hydro-alcoholic leaf extract of Litsea quinqueflora (Dennst.) Suresh by protein denaturation and free radical scavenging activity. The polyphenol-rich fraction of hydro-alcoholic leaf extract was obtained via acid-alkali hydrolysis, followed by fractionation with chloroform and ethyl acetate. HPTLC profiling of the finally obtained ethyl acetate fraction and consequent derivatisation with aluminium chloride revealed the presence of flavonoids in a more purified form. LCMS/MS analysis tentatively identified the presence of bioactive polyphenolic compounds such as gallocatechin, sinapic acid, pinocembrin, paeonol and umbelliferone in the separated fraction. The polyphenol-rich fraction of hydro-alcoholic extract of leaves showed anti-denaturing activity in heat-induced bovine serum albumin denaturation with an IC50 value of 23.59 µg/ml and was statistically significant at 0.1% level. The antioxidant property of the polyphenol-rich fraction determined by its free radical scavenging ability against DPPH and ABTS showed IC50 values 122.98 and 135.44 µg/ml respectively and was also statistically significant at 0.1% level. Hence, the traditional use of Litsea quinqueflora as an anti-inflammatory agent can be attributed to the presence of polyphenols.

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Section: Anti-inflammatory Assay: Inhibition Of Protein Denaturationmentioning

confidence: 90%

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

Jose¹,

Anilkumar²

2021

Plant Sci. Today

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“…The total phenolic content (TPC) in each plant extract was measured following the method described by Derouich et al [ 17 ]. Briefly, a hundred microliter of the diluted plant filtrate was mixed with 500 µ L of 1/10 water-diluted Folin–Ciocalteau's reagent.…”

Section: Methodsmentioning

confidence: 99%

Antifungal Potential of Phytochemicals against Mauginiella scaettae, the Plant Pathogen Causing Inflorescence Rot of Date Palm

Bouhlali¹,

Derouich²,

Meziani³

et al. 2021

Scientifica

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Date palm (Phoenix dactylifera L.) inflorescence rot caused by Mauginiella scaettae poses a serious threat to date palm in Morocco. The present study aims to determine the antifungal activity of five plant extracts against M. scaettae, including Acacia cyanophylla, Cupressus atlantica, Eucalyptus torquata, Nerium oleander, and Schinus molle and link this effect to their content in phenolics and flavonoids, as well as their antioxidant properties. Plant extracts exhibited significant discrepancies regarding their antifungal activity ( p < 0.05 ). The extracts of E. torquata and C. atlantica had the strongest and dose-dependent manner inhibitory effect against mycelial growth and spore germination. E. torquata and S. molle caused the greatest sporulation reductions of about 88.05% and 36.11%, respectively. In addition, there were significant differences among the examined plant extracts with respect to their total polyphenols (14.52–76.68 mg GAE/g DW), flavonoids (8.75–57.78 g RE/100 g DW), and antioxidant properties as measured by TEAC (74.77–391.23 mmol TE/g DW) and FRAP assays (87.18–474.04 mmol TE/g DW). Strong correlations were found between phenolic compounds and antioxidant activity suggesting that polyphenols play a key role in the observed antioxidant and antifungal activities.

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“…There is evidence (experiments with p-lactoglobulin, bovine serum albumin and soybean glycine) that the interaction between flavonoids and protein increases the thermal stability of the protein and has a great influence on its secondary structure, which explains the antidenaturation effect. Flavonoids can build hydrogen bonds with the hydrophilic heads of the lipid bilayer of the membrane and thus reduce the fluidity and increase the rigidity of the membrane, which ensures its integrity and stabilization (28).…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

“…Parsley is known as an antioxidant and anti-inflammatory agent-rich plant (the leaves contain significant levels of polyphenols and flavonoids). Various possible therapeutic indications for parsley use could be based on these effects (23,28). Parsley represent a natural safe remedy which could be used as an anti-inflammatory (reduces inflammation, especially in joints), antihyperglycemic (decreases glucose level in blood of diabetes induced rats), antihyperlipidemic (by enhancing serum lipid profile), antihypertensive (diuretic effect also contributes to blood pressure lowering), hypouricemic (high level of antioxidative substances contributes to the reduction of hyperuricemia and gout effect on liver, kidney and other tissues) and antimicrobial agent (18,19,23,31).…”

Section: Modern-day Use Of Parsleymentioning

confidence: 99%

A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley

Punoševac¹,

Radović²,

Leković³

et al. 2021

Arhiv za farmaciju

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Parsley is a biennial aromatic plant from the Apiaceae family, which is characterized by an unbranched root, pinnately divided leaves, umbels and schizocarp. It contains essential oil in all parts, with phenylpropane and terpene compounds as main components. It is rich in flavonoids and other polyphenolic compounds, containing furanocoumarins, carotenoids, polyacetylenes, and its leaves are a source of vitamins and minerals. The chemical composition of parsley depends on a number of factors, so it differs not only in different parts and varieties of the plant but also in different samples of the same parts of one variety. The most important parsley compounds are myristicin, apiol, 1-allyl-2,3,4,5-tetramethoxybenzene, b-phellandrene, 1,3,8-p-menthatriene, b-pinene, terpinolene, apiin, oxypeucedanin and falcarinol. Parsley has a long tradition of use in the treatment of urinary tract disorders, and modern in vitro and in vivo studies reveal numerous effects of various parsley preparations such as diuretic, antiurolithiasis, hypouricemic, hypolipidemic, hypoglycemic, hypotensive, antioxidant, anti-inflammatory and antiplatelet effect. Today, apart from its medical application, parsley is one of the most commonly used culinary herbs.

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Assessment of total polyphenols, flavonoids and anti-inflammatory potential of three Apiaceae species grown in the Southeast of Morocco

Cited by 25 publications

References 26 publications

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

LCMS/MS analysis and evaluation of anti-inflammatory and antioxidant activities of the polyphenol fraction of Litsea quinqueflora (Dennst.) Suresh

Antifungal Potential of Phytochemicals against Mauginiella scaettae, the Plant Pathogen Causing Inflorescence Rot of Date Palm

A review of botanical characteristics, chemical composition, pharmacological activity and use of parsley

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