Despite considerable interest in the syndrome of acute left ventricular (LV)
ballooning, its pathophysiology has remained ill-defined. In this review, we
explore observational data describing two etiologies of acute LV ballooning:
neurohumoral classic Takotsubo Syndrome (TTS), and acute severe unrelenting left
ventricular outflow tract (LVOT) obstruction in patients with obstructive
hypertrophic cardiomyopathy (HCM). We describe the clinical presentation and
varying pathophysiology of these presentations, explore how echocardiography and
cardiac catheterization may help differentiate between the two etiologies, and
detail differences in management. We highlight the significant overlap as well as
key differentiating features of these conditions, with the aim to improve
diagnostic awareness and accuracy and appropriately tailor therapy.