Assessment of trans, trans-muconic acid in human seminal plasma

Ducci, Michele; Tedeschi, D.; Rossi, P.; Gazzano, Angelo; Villani, Claudio; Voliani, S.; Bertozzi, Maria Antonella; Martelli, Franco; Menchini‐Fabris, F.

doi:10.1046/j.1439-0272.2001.00441.x

Cited by 4 publications

(3 citation statements)

References 21 publications

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“…A study in men showed that trans , trans -muconic acid ( t , t -MA) levels (a benzene metabolite) were significantly increased in teratospermic (i.e., malformed sperm), oligospermic (i.e., decreased sperm count), and asthenospermic (i.e., decreased sperm motility) individuals. Significant decreases in sperm concentration, normal sperm morphology, and viability were also correlated with increased t , t -MA levels …”

Section: Resultsmentioning

confidence: 86%

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New Look at BTEX: Are Ambient Levels a Problem?

Bolden

Kwiatkowski

Colborn

2015

Environ. Sci. Technol.

361

223

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Benzene, toluene, ethylbenzene, and xylene (BTEX) are retrieved during fossil fuel extraction and used as solvents in consumer and industrial products, as gasoline additives, and as intermediates in the synthesis of organic compounds for many consumer products. Emissions from the combustion of gasoline and diesel fuels are the largest contributors to atmospheric BTEX concentrations. However, levels indoors (where people spend greater than 83% of their time) can be many times greater than outdoors. In this review we identified epidemiological studies assessing the noncancer health impacts of ambient level BTEX exposure (i.e., nonoccupational) and discussed how the health conditions may be hormonally mediated. Health effects significantly associated with ambient level exposure included sperm abnormalities, reduced fetal growth, cardiovascular disease, respiratory dysfunction, asthma, sensitization to common antigens, and more. Several hormones including estrogens, androgens, glucocorticoids, insulin, and serotonin may be involved in these health outcomes. This analysis suggests that all four chemicals may have endocrine disrupting properties at exposure levels below reference concentrations (i.e., safe levels) issued by the U.S. Environmental Protection Agency. These data should be considered when evaluating the use of BTEX in consumer and industrial products and indicates a need to change how chemicals present at low concentrations are assessed and regulated.

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Section: Resultsmentioning

confidence: 86%

“…Significant decreases in sperm concentration, normal sperm morphology, and viability were also correlated with increased t,t-MA levels. 89 Immunological Effects. Eleven studies assessed the impact of benzene exposure on several elements of the immune system.…”

Section: ■ Resultsmentioning

confidence: 99%

New Look at BTEX: Are Ambient Levels a Problem?

Bolden

Kwiatkowski

Colborn

2015

Environ. Sci. Technol.

361

223

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“…Here, the author summarized that the determination of urine ttMA is not effective for screening for infertility in the subjects exposed to benzene. Due to a recent study of Ducci et al, seminal plasma ttMA content could be more important biological indicator for evaluating the negative effects of benzene on spermatogenesis [15].…”

Section: Usefulness Of Ttma Biomarker Determination On Detection Of Smentioning

confidence: 99%

Benzene Exposure and Spermatotoxicity

Wiwanitkit

2006

Sex Disabil

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Differential expression of proteins in rat plasma exposed to benzene

Lee

Lee²,

Joo³

et al. 2004

Proteomics

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Benzene, a ubiquitous environmental contaminant, is an important solvent in the chemical industry and is also known as a constituent of petroleum. It has been reported that benzene is associated with hematotoxicity including leukemia in humans and cancer in laboratory animals. To study protein expression alterations in rat plasma exposed to benzene, rats were exposed to levels of 1, 10, 100 ppm benzine for 6 h/day and 5 d/week for 2 or 6 weeks. Two-dimensional gel electrophoresis of rat plasma was carried out, and approximately 1000 protein spots were detected on the gels. The 11 spots which showed significantly different expression were selected and identified with matrix-assisted laser desorption/ionization-time of flight-mass spectrometry. Analyzing the targeted 11 spots, there was no correlation between the 2 and 6 weeks benzene-inhaled groups on up-regulated proteins (zinc finger protein, and tristetraprolin) and on down-regulated proteins (cAMP-regulated guanine nucleotide exchange factor II, protein kinase and unknown protein). The overexpressed proteins (inhibitor of kappaB-like protein, GTP-binding protein rab14, T-cell receptor alpha chain, and somatostatin transactivating factor-1) were detected only in groups inhaling benzene for 6 weeks. Among them the expression level of T-cell receptor alpha chain was confirmed by Western blot.

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Assessment of trans, trans-muconic acid in human seminal plasma

Cited by 4 publications

References 21 publications

New Look at BTEX: Are Ambient Levels a Problem?

New Look at BTEX: Are Ambient Levels a Problem?

Benzene Exposure and Spermatotoxicity

Differential expression of proteins in rat plasma exposed to benzene

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