Assessment of tuberculosis infection during treatment with biologic agents in a BCG-vaccinated pediatric population

Atikan, Başak Yıldız; Çavuşoğlu, Cengiz; Dortkardesler, Merve; Sözeri, Betül

doi:10.1007/s10067-014-2842-5

Cited by 10 publications

(16 citation statements)

References 27 publications

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“…3,5,8,14,16,17,20,26,31,37 There were only eight specific papers on TB in children with rheumatic diseases using biologics. One was a case-control study 12 that evaluated the risk of TB in children with JIA in Taiwan, two were retrospective studies 4,35 that evaluated the safety of anti-TNFα/ biologics in relation to TB, one was a prospective study 10 that evaluated TB during treatment with biologic agents in a population vaccinated with bacillus Calmette-Guérin (BCG), and four were case reports. 15,22,24,33 Screening for TB before starting biologic therapy was performed in just over half (19/37) of the studies.…”

Section: Resultsmentioning

confidence: 99%

“…15,22,24,33 Screening for TB before starting biologic therapy was performed in just over half (19/37) of the studies. [3][4][5][8][9][10][11]14,15,19,21,24,27,28,30,[33][34][35][36] Of the 30 cases of TB disease (PTB: 26, EPTB: 4), 8/30 occurred in patients who had been screened before biologic therapy and 22/30 in those not screened. Of the eight specific studies on TB, screening was conducted in six; of the two studies in which there was no report on screening for TB, one is the case that progressed to death.…”

Section: Resultsmentioning

confidence: 99%

“…One study 46 reported conversion of TST to positive one year after the first screening, in 30% of patients who started treatment with anti-TNFα, which could be explained by the restoration of suppressed immune reactivity against TB antigens, with a decrease in the underlying disease activity. 10 Children below five years of age may also have undetermined IGRAs. 47 From 1975 onwards, there has been the development of biologic drugs, which are medications that act on cell signaling or interaction processes, resulting in the activation and/or regulation of the immune response.…”

Section: Discussionmentioning

confidence: 99%

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Tuberculosis in children and adolescents with rheumatic diseases using biologic agents: an integrative review

Lima

Aurílio

Fonseca

et al. 2024

Rev. paul. pediatr.

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Objective: To conduct a bibliographic review on tuberculosis (TB) disease in children and adolescents with rheumatic diseases, being managed with biologic therapy. Data source: An integrative review with a search in the U.S. National Library of Medicine and the National Institutes of Health (PubMed) using the following descriptors and Boolean operators: ([“tuberculosis”] AND ([“children”] OR [“adolescent”]) AND [“rheumatic diseases”] AND ([“tumor necrosis factor-alpha”] OR [“etanercept”] OR [“adalimumab”] OR [“infliximab”] OR [“biological drugs”] OR [“rituximab”] OR [“belimumab”] OR [“tocilizumab”] OR [“canakinumab”] OR [“golimumab”] OR [“secukinumab”] OR [“ustekinumab”] OR [“tofacitinib”] OR [“baricitinib”] OR [“anakinra”] OR [“rilonacept”] OR [“abatacept”]), between January 2010 and October 2021. Data synthesis: Thirty-seven articles were included, with the total number of 36,198 patients. There were 81 cases of latent tuberculosis infection (LTBI), 80 cases of pulmonary tuberculosis (PTB), and four of extrapulmonary tuberculosis (EPTB). The main rheumatic disease was juvenile idiopathic arthritis. Among LTBI cases, most were diagnosed at screening and none progressed to TB disease during follow-up. Of the TB cases using biologics, most used tumor necrosis factor-alpha inhibitors (anti-TNFα) drugs. There was only one death. Conclusions: The study revealed a low rate of active TB in pediatric patients using biologic therapy. Screening for LTBI before initiating biologics should be done in all patients, and treatment, in cases of positive screening, plays a critical role in preventing progression to TB disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Tuberculosis in children and adolescents with rheumatic diseases using biologic agents: an integrative review

Lima

Aurílio

Fonseca

et al. 2024

Rev. paul. pediatr.

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“…Of the limited studies published in pediatric population, in a study conducted in Turkey, 71 children with inflammatory diseases were screened for LTBI prior to anti-TNF treatment and 8.45% of the children were diagnosed with LTBI with TST cut-off value ≥15 mm and/or QFT-GIT positivity. 24 In our study, we used current local guidelines which suggest TST cut-off value ≥5 mm and/or T-SPOT.TB positivity and diagnosed 18 (31.5%) of our patients with LTBI. Difference between LTBI rates is obviously the result of different TST cut-off values.…”

Section: Discussionmentioning

confidence: 99%

Screening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests

et al. 2020

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Objectives: This study aims to analyze the coherence between T-SPOT tuberculosis test (T-SPOT.TB) and tuberculin skin test (TST) with different cutoff values in screening latent tuberculosis infection (LTBI) both prior to and at the sixth month of anti-tumor necrosis factor (anti-TNF) treatment. Patients and methods: This prospective multicentric study included 57 children (34 girls, 23 boys, mean age 12.4±3.9 years; range, 6 to 18 years) diagnosed with immune-mediated inflammatory diseases (IMIDs) evaluated with TST and T-SPOT.TB for screening LTBI both prior to and at the sixth month of treatment with anti-TNF agents. Coherence between two tests was analyzed for TST cutoff values suggested by the local guidelines and also for different possible cutoff values of TST. Results: Tuberculin skin test was positive (≥5 mm) in 28.1% (n=16) of patients in the screening prior to treatment and in 33.3% (n=19) at the sixth month of treatment. T-SPOT.TB test was positive in 8.8% (n=5) of patients both prior to and at the sixth month of treatment. Coherence between two tests was poor or fair when compared with all possible TST cutoff values both prior to and at the sixth month of anti-TNF therapy. Conclusion: Our results show poor coherence between T-SPOT.TB and TST for all possible cutoff values of TST. Thus, using both tests would be beneficial in screening LTBI until further studies bring new evidence on the subject.

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“…Moreover, only four departments were selected to meet the purpose of the study: food and beverages, frontline office, housekeeping, and marketing departments [56]. Furthermore, purposive sampling was chosen to focus on people with particular characteristics compatible with the research purpose [81]. Four hundred and nine questionnaires were returned out of 700 distributed among the participants.…”

Section: Sample and Proceduresmentioning

confidence: 99%

Impact of internal brand management on sustainable competitive advantage: An explanatory study based on the mediating roles of brand commitment and brand citizenship behavior

et al. 2022

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The existing literature on internal branding has often adopted a managerial-based approach and seldom considered employees’ perceptions. Therefore, there is a need to understand the perspective of frontline and non-managerial employees. In this context, the current study investigates the impact of internal brand management on brand commitment, brand citizenship behavior, and sustainable competitive advantage for the hotel industry. A survey-based quantitative data was gathered from 390 non-managerial frontline staff working in 3-, 4-, and 5-star hotels of Pakistan. The results revealed that internal brand management positively impacts brand commitment, brand citizenship behavior, and sustainable competitive advantage. Besides, brand commitment has a positive impact on brand citizenship behavior and sustainable competitive advantage. Moreover, brand citizenship behavior has a positive impact on sustainable competitive advantage. In addition, the mediating roles of brand commitment and brand citizenship behavior exist between internal brand management and sustainable competitive advantage. The research implications, together with research limitations, have also been discussed.

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Assessment of tuberculosis infection during treatment with biologic agents in a BCG-vaccinated pediatric population

Cited by 10 publications

References 27 publications

Tuberculosis in children and adolescents with rheumatic diseases using biologic agents: an integrative review

Tuberculosis in children and adolescents with rheumatic diseases using biologic agents: an integrative review

Screening for Latent Tuberculosis in Children With Immune-Mediated Inflammatory Diseases Treated With Anti-Tumor Necrosis Factor Therapy: Comparison of Tuberculin Skin and T-SPOT Tuberculosis Tests

Impact of internal brand management on sustainable competitive advantage: An explanatory study based on the mediating roles of brand commitment and brand citizenship behavior

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