Assessment of tumor lysis syndrome cases

Abstract

Tumor lysis syndrome (TLS) is a clinical picture that occurs with the rapid destruction of tumor cells and with life-threatening metabolic disorders. The aim of our study is to evaluate the etiologic causes, diagnosis and treatment of TLS cases. Method: The study was conducted between January 2015 and December 2017 in Kahramanmaras Necip Fazıl city Hospital. A total of 32 patients diagnosed with TLS were included in the study. Laboratory values of patients were scanned (blood urea nitrogen, creatinine, potassium, phosphorus, calcium, serum uric acid, lactate dehydrogenase) and diagnoses, chemotherapy and treatments were noted. Results: Of the 32 patients who were included in the study, 17 were male and 15 were female. The average age of the patients was found as 62,06 ± 12,10 (35-86) years. Hematologic malignancy was detected in the etiology of 11 of the TLS cases and solid tumor was detected in 21 of the TLS cases. A total of 12 (37.5%) patients had spontaneous TLS (5 in haematological malignancy and 7 in solid tumor). Hyperpotassaemia 50%, hypocalcaemia 46.9%, hyperphosphatemia, hyperuricemia and acute kidney damage was present in all patients. Mortality rate was found as 40.6%. Conclusions: In our study, spontaneous TLS was detected at a high rate. In addition, the mortality rate was also high. Early diagnosis and urgent treatment should be planned to avoid mortalities.

Tümör Lizis Sendromunda Hemşirelik Yaklaşımı

“…İyi yönetilmediğinde elektrolit dengesizlikleri, akut böbrek hasarı, asit-baz dengesizlikleri ve ölüm gibi potansiyel olarak yaşamı tehdit eden komplikasyonlar oluşturabilmektedir (Kaplow ve Iyere, 2016). TLS insidansı oldukça değişkendir ve sıklığı malignite tipine göre değişmektedir (Hüzmeli, 2019). TLS ile ilişkili en yaygın maligniteler arasında non-Hodgkin lenfoma (% 30), katı tümörler (% 20), akut miyeloid lösemi (% 19) ve akut lenfositik lösemi (% 13) yer almaktadır (Adeyinka ve Bashir, 2019).…”

“…TLS ile ilişkili en yaygın maligniteler arasında non-Hodgkin lenfoma (% 30), katı tümörler (% 20), akut miyeloid lösemi (% 19) ve akut lenfositik lösemi (% 13) yer almaktadır (Adeyinka ve Bashir, 2019). TLS insidansını arttırabilen yüksek proliferasyon hızına sahip tümörler, kemoterapiye duyarlılığı yüksek olan tümörler, böbrek hastalığı öyküsü gibi doğal risk faktörleri bulunmaktadır (Adeyinka ve Bashir, 2019;Hüzmeli, 2019). Bu çalışmanın amacı TLS' de hemşirelik yaklaşımını incelemektir.…”