An effective approach for estimating turbulence-chemistry interaction in hypersonic turbulent boundary layers is proposed, based on "laminar-chemistry" Reynolds-averaged Navier-Stokes mean flow solutions. The approach combines an assumed probability density function with a temperature fluctuation scaling, which provides the second moment for specifying the shape of the probability density function. As a result, the effects of temperature fluctuation on chemical production rates can be estimated without solving an additional moment evolution equation. The validity of this method is demonstrated using direct-numerical-simulation data. This approach can be used to identify regions with potentially significant turbulence-chemistry interaction in hypersonic boundary layers, and it provides guidance on whether or not additional efforts need to be taken to model turbulence-chemistry interaction under selected flow conditions. Nomenclature c = concentration, c s s =W s , mol=m 3 H = shape factor, =, dimensionless h = specific enthalpy, J=kg h = heat of formation, J=kg K eq = equilibrium constant k = reaction rate coefficient or turbulence kinetic energy, u 02 v 02 w 02 =2, m 2 =s 2 M = Mach number, dimensionless ns = total number of species, dimensionless Re 2 = Reynolds number, u = w , dimensionless Re = Reynolds number, u = , dimensionless Re = Reynolds number, w u = w , dimensionless T = temperature, K T a = activation temperature, K u = streamwise velocity, m=s v = spanwise velocity, m=s W = molecular weight, kg=mol w = chemical production rate, kg=m 3 s, or wall-normal velocity, m=s Y = mass fraction, dimensionless = boundary-layer thickness, mm = displacement thickness, mm = momentum thickness, mm = stoichiometric coefficient, dimensionless = density, kg=m 3 Subscripts b= backward reaction f = forward reaction s = chemical species w = wall variables x, y, z = streamwise, spanwise, and wall-normal directions, respectively, for spatial coordinates = boundary-layer edge Superscript = inner wall units