Assessment of unilateral condylar hyperplasia with quantitative SPECT/CT

Liu, Pingan; Shi, Jun

doi:10.1016/j.heliyon.2023.e23777

Heliyon

2024

DOI: 10.1016/j.heliyon.2023.e23777

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Assessment of unilateral condylar hyperplasia with quantitative SPECT/CT

Pingan Liu,

Jun Shi

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2024

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Cited by 2 publications

References 21 publications

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Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia

Anzola,

Venegas,

Jaramillo

et al. 2024

Diagnostics

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Objectives: This analytical cross-sectional study evaluates diagnostic approaches for active condylar hyperplasia using bone SPECT techniques. Methods: it was compared the effectiveness of relative activity assessments between condyles and quantitative analysis using the condyle/clivus ratio. Results: This study’s findings reveal that the condyle/clivus ratio method significantly outperforms the relative uptake method, achieving a sensitivity of 90.1% (95% CI: 84.1–94) compared to 40.7% (95% CI: 33.5–48.2), and a specificity of 77.1% (95% CI: 67.4–85) versus 72.9% (95% CI: 62.9–81.5). The condyle/clivus ratio also showed a more favorable negative likelihood ratio of 0.13 compared to 0.82 for relative uptake, and a higher area under the curve (AUC) of 0.8360 versus 0.5679. Statistically significant differences were noted (p = 0.0001). The condyle/clivus ratio method effectively identifies affected condyles in unilateral and bilateral condylar hyperplasia cases. Conclusions: This study emphasizes the importance of incorporating comprehensive clinical evaluations and imaging modalities for assessing condylar growth activity, underscoring the need for tailored reference values in different populations to ensure reliable diagnostic interpretations.

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Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia

Anzola,

Venegas,

Jaramillo

et al. 2024

Diagnostics

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Unilateral “Inactive” Condylar Hyperplasia: New Histological Data

Anastasi,

Centofanti,

Favaloro

et al. 2024

JFMK

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Background: Unilateral condylar hyperplasia (UCH) is characterized by slow progression and enlargement of the condyle, accompanied by elongation of the mandibular body, resulting in facial asymmetry, occlusal disharmony, and joint dysfunction. This condition can be defined as “active” or “inactive”: the active form is characterized by continuous growth and dynamic histologic changes, whereas the inactive form indicates that the growth process has stabilized. Since there are few microscopic studies on the inactive form, this study aims to investigate the histological features and expression of key proteins and bone markers in patients diagnosed with inactive UCH. Methods: A total of 15 biopsies from patients aged 28 to 36 years were examined by light microscopy and immunofluorescence for collagen I and II, metalloproteinases 2 (MMP-2) and 9 (MMP-9), receptor activator of nuclear factor- kappa B (RANK), and osteocalcin. Results: Our findings indicate that during inactive UCH, the ongoing process is not entirely stopped, with moderate expression of collagen, metalloproteinases, RANK, and osteocalcin, although no cartilage islands are detectable. Conclusions: The present study shows that even if these features are moderate when compared to active UCH and without cartilage islands, inactive UCH could be characterized by borderline features that could represent an important trigger-point to possible reactivation, or they could represent a long slow progression that is not “self-limited”.

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Assessment of unilateral condylar hyperplasia with quantitative SPECT/CT

Cited by 2 publications

References 21 publications

Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia

Diagnostic Efficacy of Bone SPECT Techniques in Differentiating Unilateral and Bilateral Condylar Hyperplasia

Unilateral “Inactive” Condylar Hyperplasia: New Histological Data

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