Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study

Farah, Gustavo Jacobucci; Ferreira, Gustavo Zanna; Danieletto-Zanna, Carolina Ferrairo; Luppi, Caroline Resquetti; Jacomacci, Willian Pecin

doi:10.1016/j.joms.2019.05.003

Cited by 19 publications

(31 citation statements)

References 26 publications

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“…Both quantitative and qualitative studies with human subjects were included. Of 40 articles using valerian as a single herb, 36 studies were randomized controlled trials (RCT) 30–65 and 2 studies were observational. 66,67 Two studies addressed the potential induction of liver enzyme cytochrome P450 (CYP) isoforms.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies examined valerian’s anxiolytic potential, and positive outcomes were observed in 6 studies. 33,35,43,60,63,71 Valerian standardized extract 600 mg per day for 1 week reduced psychological and physiological stress reactivity under stress in healthy adult subjects 43 (RCT [Jadad scale 1]). Average 81.3 mg per day of valepotriates for 4 weeks reduced the score of HAM-A in generalized anxiety disorder patients 71 (RCT [Jadad scale 5]), suggesting that valepotriates are the active anxiolytic constituents.…”

Section: Resultsmentioning

confidence: 99%

“…Seven studies examined valerian's anxiolytic potential, and positive outcomes were observed in 6 studies. 33,35,43,60,63,71 Valerian standardized extract 600 mg per day for 1 week reduced psychological and physiological stress reactivity under stress in healthy adult subjects 43 anxiety in anxious patients undergoing dental operation 33,60 (RCTs [Jadad scale 5]). In addition, valerian extract 1,260 mg per day for 7 days for 3 menstrual cycles effectively reduced premenstrual anxiety 63 (RCT [Jadad scale 5]).…”

Section: Officinalis (And Piper Methysticum)mentioning

confidence: 99%

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Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Shinjyo

Waddell

Green

2020

J Evid Based Complementary Altern Med

103

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Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian ( Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders. PubMed, ScienceDirect, and Cochrane Library were searched to retrieve publications relevant to the effectiveness of valerian as a treatment of sleep problems and associated disorders. A total of 60 studies (n=6,894) were included in this review, and meta-analyses were performed to evaluate the effectiveness to improve subjective sleep quality (10 studies, n=1,065) and to reduce anxiety (8 studies, n=535). Results suggested that inconsistent outcomes were possibly due to the variable quality of herbal extracts and that more reliable effects could be expected from the whole root/rhizome. In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners. There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years. In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders. However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Officinalis (And Piper Methysticum)mentioning

confidence: 99%

See 1 more Smart Citation

Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Shinjyo

Waddell

Green

2020

J Evid Based Complementary Altern Med

103

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“…Anxiety disorders are common prevalent mental disorders (0.9%-28.3%) (Baxter et al, 2013). Farah et al (2019) investigated the anti-anxiety effect of V. officinalis (100 mg in capsules, 60 minutes before the surgical procedure) and compared its effectiveness with midazolam (15 mg in tablets) in patients with anxiety due to bilateral extraction of mandibular third molars. This study revealed that midazolam is more potent as an anxiolytic drug, but V. officinalis causes less adverse effects (sedation and somnolence).…”

Section: Clinical Trialsmentioning

confidence: 99%

“…Moreover, valerian (2 capsules daily for three months) reduced emotional, physical, and behavioral symptoms of premenstrual syndrome in women university students (Behboodi Moghadam et al, 2016). Regarding adverse effects, only two of the thirteen clinical trials have reported adverse drug reactions (Ahmadi et al, 2017;Farah et al (2019). Remarkably, these adverse events were dizziness, somnolence, and nausea.…”

Section: Clinical Trialsmentioning

confidence: 99%

Updating the biological interest of 'Valeriana officinalis'

Sánchez¹,

González-Burgos²,

Iglesias³

et al. 2021

Mediterr. Bot.

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Valeriana officinalis L. (Caprifoliaceae) has been traditionally used to treat mild nervous tension and sleep problems. The basis of these activities are mainly attributed to valerenic acid through the modulation of the GABA receptor. Moreover, V. officinalis is claimed to have other biological activities such as cardiovascular benefits, anticancer, antimicrobial and spasmolytic. The current review aims to update the biological and pharmacological studies (in vitro, in vivo and clinical trials) of V. officinalis and its major secondary metabolites in order to guide future research. Databases PubMed, Science Direct and Scopus were used for literature search including original papers written in English and published between 2014 and 2020. There have been identified 33 articles which met inclusion criteria. Most of these works were performed with V. officinalis extracts and only a few papers (in vitro and in vivo studies) evaluated the activity of isolated compounds (valerenic acid and volvalerenal acid K). In vitro studies focused on studying antioxidant and neuroprotective activity. In vivo studies and clinical trials mainly investigated activities on the nervous system (anticonvulsant activity, antidepressant, cognitive problems, anxiety and sleep disorders). Just few studies were focused on other different activities, highlight effects on symptoms of premenstrual and postmenopausal syndromes. Valeriana officinalis continues to be one of the medicinal plants most used by today's society for its therapeutic properties and whose biological and pharmacological activities continue to arouse great scientific interest as evidenced in recent publications. This review shows scientific evidence on traditional uses of V. officinalis on nervous system.

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Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial

Velasquez,

Tsuji,

dos Santos Cordeiro

et al. 2024

Oral Maxillofac Surg

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Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study

Cited by 19 publications

References 26 publications

Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Updating the biological interest of 'Valeriana officinalis'

Effects of Passiflora incarnata and Valeriana officinalis in the control of anxiety due to tooth extraction: a randomized controlled clinical trial

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