Assessment of Venous Blood Leukocyte Profiles and Immunoglobulin E Levels in Atopic Dermatitis Patients

Abstract

BackgroundThere are differing results in the literature regarding the relationship between atopic dermatitis (AD) and peripheral blood leukocyte profiles.ObjectiveThe aim of the study was to investigate the relationship between AD, blood immune cell profiles, and disease severity.MethodsOne hundred AD patients aged 1 month to 18 years without any history of infection or systemic disease were enrolled as the study group. Serum concentration levels of total immunoglobulin E, calculated blood leukocyte profiles, and AD index severity scoring were calculated for statistical comparison.ResultsThe differences between the groups for neutrophil-lymphocyte ratio and eosinophil-lymphocyte ratio were statistically different. However, there was no statistically significant correlation between the investigated parameters and AD index severity scoring.ConclusionsAlthough significant differences were found in some of the parameters between the groups, unfortunately, the lack of correlation between the parameters investigated and the disease severity index restricts their use in clinical practice.

The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

“…A study (patient group aged between 1 month and 18 years) reported that ELR could be a significant factor in AD diagnosis, similar to our results; however, they also reported higher NLR in the AD group. 21 However, another study (aged 5.6+/-2.8 years) reported no significant difference between the two groups regarding NLR. 22 Another study (60.0±46.5 months-aged patient group) reported increased NLR and PLR in AD but no difference regarding MPV.…”