Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data

Chicoine, Alan; Erdely, Holly; Fattori, Vittorio; Finnah, Anke; Fletcher, Samuel C.; Lipp, Markus; Sandérs, Pascal; Scheid, Stefan

doi:10.1016/j.yrtph.2020.104806

Cited by 15 publications

(5 citation statements)

References 3 publications

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“…Animal liver is a common matrix for the search of chemical residues for several reasons. On the one hand, the use of veterinary drugs, which is widely accepted in veterinary practice to treat bacterial infections, parasitism (internal or external), inflammation, and other animal diseases or their symptoms in livestock practice [1,2], may condition the appearance of residues of these chemicals in foods of animal origin, especially in the liver [3][4][5]. This is particularly relevant, since the presence of antimicrobial compounds can induce the spread of drug-resistant pathogenic bacterial strains or produce allergic reactions in humans [3,6].…”

Section: Introductionmentioning

confidence: 99%

“…According to the European regulations, the liver must be investigated for the presence of several hundred compounds, including pesticides commonly used in agriculture, pesticides already banned but of great environmental persistence, and also residues of veterinary drugs [7]. Although there are differences between countries, if we take as a common reference what is established in the Codex Alimentarius, there are at least maximum residue limits (MRLs) established for some 218 pesticides and for another 75 veterinary drugs (also including combinations of drugs and animal feed) [4,5].…”

Section: Introductionmentioning

confidence: 99%

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A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring

Rial-Berriel

Acosta-Dacal

Zumbado

et al. 2021

Toxics

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The screening of hundreds of substances belonging to multiple chemical classes in liver is required in areas such as food safety or biomonitoring. We adapted a previous QuEChERS-based method in blood to the liver matrix and applied to these fields of study. The validation of the method allowed the inclusion of 351 contaminants, 80% with a LOQ < 2 ng/g. In the analysis of 42 consumer liver samples, we detected trace levels of 29 different contaminants. The most frequent and concentrated was 4,4’-DDE. POPs accounted for 66% of the compounds detected. In no case was the MRL reached for any of the contaminants detected. We also applied the method to 151 livers of wild birds to perform a biomonitoring pilot study in the Canary Islands. We detected 52 contaminants in 15 bird species. These were also mostly POPs, although high frequencies and concentrations of anticoagulant rodenticides (AR) and some other agricultural pesticides also stand out. POPs and AR contamination levels were significantly higher in terrestrial birds, raptors and particularly in nocturnal birds. Pesticide contamination levels were also higher in terrestrial birds, as well as in non-raptors and diurnal birds. The validated method is simple, robust, and sensitive and performs well in a variety of practical scenarios, where it can be carried out relatively quickly and inexpensively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring

Rial-Berriel

Acosta-Dacal

Zumbado

et al. 2021

Toxics

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“…Veterinary drugs, including antiparasitics, antibiotics, and growth promoters, are crucial for preserving the wellbeing and production of agricultural animals, and the health of companion animals [4]. As veterinary drugs are frequently used to enhance animal development and to prevent sickness in food-producing animals, there may be drug residues in foods such as meat, milk, eggs, or honey [5][6][7]. Veterinary drug residues refer to the residues of veterinary drug parent compounds or metabolites contained in any edible part of animal products, as well as impurities related to veterinary drugs [8].…”

Section: Introductionmentioning

confidence: 99%

A Review of Veterinary Drug Residue Detection: Recent Advancements, Challenges, and Future Directions

Jun

Wan

2023

Sustainability

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Veterinary drug residues of common food (milk, meat) have posed serious threats to the environment and human health, making the quality and safety of agricultural, livestock, and aquatic products increasingly prominent. With the widespread use of veterinary drugs and the requirements for food safety, it has become urgent to detect veterinary drug residues in animal-derived foods. So far, few studies have systematically reviewed the progresses, challenges, and future directions in veterinary drug residue detection. A thorough review on the current advancements, challenges, and potential future directions of veterinary drug residue detection will be extremely beneficial and timely. This study reviewed recent developments of detection technology of veterinary drug residues. The current issues and challenges in veterinary drug residue detection were examined and highlighted. Finally, future proposals on directions and prospects for veterinary drug residue detection were suggested. High-throughput and high-sensitivity veterinary drug detection technology, sample pretreatment technology for rapid processing, and the fusion of multiple detection methods were recommended as the main directions for the future development of veterinary drug residue detection. It was suggested to develop the analysis and detection technologies of veterinary drug residue towards high automation, high sensitivity, and high throughput in the future. This review provides new ideas and strategies for the rapid development of animal husbandry industry and protecting consumers’ physical health and food safety.

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“…Therefore, establishing a modified analytical technique is necessary to conform with the present legislation. Liquid chromatography (LC) combined with other discovery systems, such as UV or diode array, fluorescence or mass spectrometry (MS), is considered the best technique to quantify multiresidues of veterinary drugs (Chicoine et al, 2020). However, many methods used for the quantification of anthelmintic drug residues in animal‐derived foods, such as high‐performance liquid chromatography with ultraviolet (HPLC‐UV) spectroscopy (Cirkovic et al, 2015; Gili et al, 2014), ultra‐high‐pressure liquid chromatography (UHPLC) with different types of detector depending on the nature of the analytes (da Silva et al, 2017; Del Bianchi A. Cruz et al, 2018), micellar LC (Pawar et al, 2021), capillary zone electrophoresis tandem mass spectrometry (MS/MS) (Tejada‐Casado et al, 2018), and recently LC–MS/MS, have been considered as advanced systematic techniques to quantify anthelmintic drugs in various animal‐based foodstuffs (Baralla et al, 2020; Casey et al, 2021; Mooney et al, 2019; Yoo et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Optimization and validation of high‐performance liquid chromatography using modified QuEChERS to determine anthelmintic drugs in mutton

Hiwa,

Khulod

2023

Biomedical Chromatography

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The aim of this study was to rapidly determine the presence of anthelmintic drugs in sheep meat using the optimized high‐performance liquid chromatography‐ultraviolet (HPLC‐UV) method with modified QuEChERS (quick, easy, cheap, effective, rugged, safe) technology. Fifty fresh sheep meat samples from different slaughterhouses were collected. A double extraction procedure (QuEChERS/HPLC‐UV technology) was used to extract the target analytes. A multilevel calibration curve from 1 to 1000 g/kg was used to establish instrument linearity for rafoxanide, albendazole, and closantel, whereas 0.1–100 μg/kg was used for ivermectin, levamisole, and oxyclozanide to find the lowest concentration, maximum residue limit (MRL), and occupied range for targeted analytes. The concentration levels were used to investigate the linearity, whereas several certified reference materials were applied to determine accuracy. The process was linear for all combinations, from the limit of quantification (LOQ) to the maximum concentration. The LOQ was established at 0.5 μg/kg for ivermectin, levamisole, and oxyclozanide and 10 μg/kg for rafoxanide, albendazole, and closantel. Recovery values were 70%–120%, and repeatability/reproducibility stated in relative standard deviation was obtained at less than 20%. QuEChERS method revealed that most meat samples contained anthelmintic drug residues, of which the majority exceeded the MRLs. Thus, the drugs should be used correctly in animals to avoid residues in food for human consumption.

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Assessment of veterinary drug residues in food: Considerations when dealing with sub-optimal data

Cited by 15 publications

References 3 publications

A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring

A Method Scope Extension for the Simultaneous Analysis of POPs, Current-Use and Banned Pesticides, Rodenticides, and Pharmaceuticals in Liver. Application to Food Safety and Biomonitoring

A Review of Veterinary Drug Residue Detection: Recent Advancements, Challenges, and Future Directions

Optimization and validation of high‐performance liquid chromatography using modified QuEChERS to determine anthelmintic drugs in mutton

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