Assessment of vision-related function in patients with age-related macular degeneration

Mackenzie, Paul J.; Chang, Tom; Linder, M; Hay, Dawn; Feuer, William J.; Chambers, Keith

doi:10.1016/s0161-6420(01)01021-1

Cited by 81 publications

(58 citation statements)

References 41 publications

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“…12 This pathology impairs macular function, causing reduced visual acuity and diminished contrast sensitivity. 13,14 In the worst cases, it causes a complete loss of central vision, interfering with reading or performing tasks that require the ability to see in detail. 15 Data were taken from 14 patients with unilateral ARMD, including ammetropes or patients with optimal correction, in different states of this retinal pathology.…”

Section: Patientsmentioning

confidence: 99%

New testing software for quantifying discrimination capacity in subjects with ocular pathologies

et al. 2011

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Abstract. We develop a new visual test, designed as software for quantifying discrimination capacity under lowillumination conditions. This is an important task in the presence of visual disturbances, such as those perceived by subjects with some ocular pathologies. For this purpose, we propose a visual-disturbance index, checking the test with two groups of observers having different ocular pathologies: a group with unilateral keratitis and another group affected with age-related macular degeneration (ARMD). To compare the test results to objective data, we use a double-pass device to measure the Strehl ratio, a parameter that quantifies the retinal-image quality, taking into account aberrations, retinal reflection, and intraocular scattering working jointly. Diseased eyes present higher disturbance indexes and a lower Strehl ratio compared to their healthy fellow eyes, registering a significant descending correlation between the disturbance index and the Strehl ratio. The lower the Strehl ratio is, the higher the disturbance index for the eyes studied. Therefore, in keratitis and ARMD eyes, our results demonstrate a deterioration in the retinal-image quality and a lower discrimination capacity to peripheral stimuli, reducing visual performance. The test presented here could be useful for the study and time course in different eye diseases, especially those involving an increase in scattered light or alterations in the ocular media, as shown in this work.C 2011 Society of Photo-Optical Instrumentation Engineers (SPIE).

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Section: Patientsmentioning

confidence: 99%

New testing software for quantifying discrimination capacity in subjects with ocular pathologies

et al. 2011

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“…Following the suggestion of the AMA's Guides to the Evaluation of Permenant Impairment, the weighted average gives a factor of 0.75 to the better eye and a factor of 0.25 to the worse eye. 5 In calculating LogMAR scores, counting fingers were assigned a Snellen VA of 20/1000, hand motion 20/2000, and light perception or no light perception 20/4000. 10 The VFQ's reliability and validity has been tested and confirmed on a heterogeneous group of patients with eye conditions, such as age-related macular degeneration, glaucoma, cataract, viral retinitis, and diabetic retinopathy.…”

Section: Definitions and Scoringmentioning

confidence: 99%

“…Although VA is an objective measure of macular function, in recent years, it has been shown that the eye diseases can affect various aspects of vision beyond acuity, such as glare, contrast sensitivity, colour vision, and stereoscopic vision. 5,6 Recognizing that VA alone fails to capture the impact of vision disability, the National Eye Institute Visual Function Questionnaire-25 (VFQ) was developed to measure self-reported, vision-related aspects of health status that are most significant to individuals with chronic eye disease. [7][8][9] To this end, the VFQ survey assesses the ability to perform vision-related daily activities and the impact of visual impairment on emotional and social domains.…”

Section: Introductionmentioning

confidence: 99%

The utility of visual function questionnaire in the assessment of the impact of diabetic retinopathy on vision-related quality of life

Gabrielian

Jager

Green

et al. 2009

Eye

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Aims To determine whether the Visual Function Questionnaire-25 (VFQ) is a more accurate instrument for assessing vision related quality of life (VRQOL) than visual acuity (VA) in patients with diabetic retinopathy. To compare VRQOL between patients with non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR). Methods We administered the VFQ and Vision Preference Value Scale (VPVS) to 104 patients. With VPVS as the gold standard in our study, we used Pearson's correlation and multiple linear regression analysis to assess whether VFQ is a more accurate measure of VRQOL than VA. Spearman correlation coefficients were used to assess which VFQ subscales correlated strongly with VPVS. Patients with NPDR and PDR were compared using VFQ. Results The Pearson's correlation coefficient between VPVS and VFQ was 0.49 (Po0.01) and between VPVS and VA was 0.33 (Po0.01). In multivariable linear models, VFQ explained a higher proportion of the variance in VPVS than VA. The VFQ subscales with the strongest Spearman coefficients to VPVS scores were role differences, near activities, distance activities, mental function and dependence. In these subscales, patients with PDR vs NPDR suffered a 25-30 point loss (100-point scale). Conclusions VFQ is a superior measure of VRQOL for patients with diabetic retinopathy because it better captures mental and emotional aspects of the disease as well as visual function. Subjects with PDR vs NPDR suffer significant loss of VRQOL.

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“…We also found that the level of visual impairment experienced by CPEO patients is significant when compared to that reported in common ophthalmic conditions such as cataract, 4 glaucoma, 5 and age-related macular degeneration (Table 3). 6 We were surprised that there were no significant differences in VF-14 scores between patients with and without diplopia. This might reflect the small sample size, given the relative rarity of the condition, or the fact that diplopia was intermittent or controlled with prisms in most cases.…”

Section: Eyementioning

confidence: 94%

“…2 As ophthalmoplegia is one of the most common manifestations of mitochondrial cytopathies, any mitochondrial disease rating scale should include questions about visual function. 3 The Visual Function Index (VF-14) is a standardised vision-related quality-of-life instrument that has been validated in a wide range of ophthalmic conditions such as cataract surgery, 4 glaucoma, 5 age-related macular degeneration, 6 corneal transplantation, 7 retinal disease, 8 myopia, 9 and patients attending low-vision services. 10 Here, we report the first study to assess visual function in patients suffering from a mitochondrial disorder with ocular manifestations: CPEO.…”

Section: Introductionmentioning

confidence: 99%

Assessment of visual function in chronic progressive external ophthalmoplegia

Yu‐Wai‐Man

Smith

Chinnery

et al. 2005

Eye

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Aims To assess the visual function of patients with chronic progressive external ophthalmoplegia (CPEO) using the Visual Function Index (VF-14). To identify discriminatory questions that reflect visual disability in mitochondrial ocular myopathies. To investigate the relationship between visual impairment and the ocular parameters routinely measured in clinical practice. Methods We studied 40 CPEO patients. Each patient underwent ophthalmological assessment, including best-corrected visual acuity, ptosis measures, and fundus examination for pigmentary retinopathy, and orthoptic assessment including cover test in the primary position, assessment of diplopia, and measurement of uniocular fields of fixation using the Goldmann perimeter. Patients were interviewed by telephone by an independent observer and their visual function was assessed using the VF-14. Results A total of 38 patients (95%) were visually impaired. The mean VF-14 was 72 (95% CI 66-79). Patients reported having the most difficulty with reading small print and driving at night. No significant correlation was found between the VF-14 and ocular motility parameters, ptosis, or pigmentary retinopathy. Conclusions CPEO is associated with significant visual impairment. Measures of visual disability should be included in studies of natural history and treatment of mitochondrial ocular myopathies.

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Assessment of vision-related function in patients with age-related macular degeneration

Cited by 81 publications

References 41 publications

New testing software for quantifying discrimination capacity in subjects with ocular pathologies

New testing software for quantifying discrimination capacity in subjects with ocular pathologies

The utility of visual function questionnaire in the assessment of the impact of diabetic retinopathy on vision-related quality of life

Assessment of visual function in chronic progressive external ophthalmoplegia

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