Assessment of Vitamin D status and association with inflammation: Biomarkers Reflecting Inflammation and Nutritional Determinants of Anemia (BRINDA) project

Is There an Association Between Inflammation and Serum-Vitamin D? – Results of a Retrospective Analysis of Hospitalized Geriatric Patients

“…Young et al 13 retrospectively analyzed the data of 9880 preschool children and 14,749 nonpregnant females from nutrition surveys and correlated inflammation biomarkers with 25(OH)D concentration without finding a significant association.…”

A Practical Guide to Adjust Micronutrient Biomarkers for Inflammation Using the BRINDA Method

“…In the past few years, BRINDA has published a series of papers providing guidance on how to adjust micronutrient biomarkers, namely retinol binding protein (RBP) [ 8 , 9 ], serum retinol [ 8 , 9 ], serum ferritin [ 8 ], soluble transferrin receptor (sTfR) [ 10 ], serum zinc [ 11 ], serum and red blood cell (RBC) folate [ 12 ], serum B-12 [ 12 ], and vitamin D [ 13 ], using inflammation markers α-1-acid glycoprotein (AGP) and/or C-Reactive Protein (CRP) [ 6 ]. In this section, we will first present whether these micronutrient biomarkers should be adjusted for inflammation, and if so, by which inflammation markers (both AGP and CRP, only AGP, or only CRP).…”

“…To date, BRINDA has compiled a global micronutrient database with 30 datasets on preschool-age children (PSC) (n ¼ 20,000) from 26 countries and 24 datasets on nonpregnant women of reproductive age (WRA) (n ¼ 56,000) from 23 countries. Using its rich data source, BRINDA published a series of papers to provide methods to adjust for inflammation on key micronutrient biomarkers, such as biomarkers for vitamin A, iron, folate, vitamin B-12, zinc, and vitamin D [4,[6][7][8][9][10][11][12][13]. BRIN-DA's effort to systematically address the role of inflammation in assessing micronutrient status has been recognized by the international community and is included in WHO guidelines [14] and CDC's Micronutrient Manual and Toolkit [15].…”