Assessment of Vitamin D status in a group of Egyptian children with non alcoholic fatty liver disease (multicenter study)

Ahmed, Amal Mohamed; Ghany, Maha Abdel; Hakeem, Gehan Lotfy Abdel; Kamal, Amr; Khattab, Rania Abdelmonem; Abdalla, Asmaa; Fotoh, Laila El Morsi Abou El; El-Mazary, Abdel-Azeem M.; Sayed, Madiha Abdalla; Fadil, Ashraf Mohamed Abdel

doi:10.1186/s12986-016-0112-z

Cited by 12 publications

(8 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, a significant lower amount of vitamin D was observed among NAFLD patients in compare to non‐NAFLD subjects, after adjusting for potential confounders . Similarly, the associations between low levels of serum vitamin D and liver dysfunction and elevated serum transaminases was reported in several studies previously . Moreover, a study has previously showed that vitamin D deficient rats had a higher amount of LDH activity, which might be an indicator of cardiac damages .…”

Section: Discussionsupporting

confidence: 84%

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

et al. 2019

View full text Add to dashboard Cite

Limited studies have examined the effects of vitamin D on liver enzymes in patients with liver disease but none has explored its effects in the healthy subjects. The aim of present study was to evaluate the effects of a high dose vitamin D supplementation on measures of liver function. A total of 988 adolescent girls were recruited; all were assessed for liver function tests (LFTs) including alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), gamma-glutamyl transferase (ΥGT), alkaline phosphatase (ALP), total bilirubin, direct bilirubin, albumin, and total protein before and after supplementation with 50,000 IU cholecalciferol perls. Significant reductions were observed for AST, ALT, direct bilirubin, total bilirubin, LDH, and ΥGT at the end of supplementation, only in the group with abnormal reference value. Serum levels of total protein and albumin were higher at the end of follow up in the group with abnormal value. No significant change was obtained for LFTs in the group with normal value. Our BioFactors 335Research Communication findings suggest that vitamin D supplementation may improve markers of liver function in adolescents with abnormal LFTs. More randomized controlled trial with longer follow-up time will be required. © 2019 BioFactors, 45(3): [335][336][337][338][339][340][341][342] 2019

show abstract

Section: Discussionsupporting

confidence: 84%

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As shown in Figure 3, the omission of the studies by Mohamed et al [26] and Black et al [28] resulted in a greater change in the estimated values than did omission of the other studies. However, significant relationships were noted between the low levels of vitamin D and children with NAFLD in all situations.…”

Section: Resultsmentioning

confidence: 96%

“…The eight included studies were three case-control studies [23–25] and five cross-sectional studies [17, 26–29]. The characteristics of all studies on the association between vitamin D and NAFLD in children and adolescents are presented in Tables 2 and 3.…”

Section: Resultsmentioning

confidence: 99%

The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Zhu

Wang

Luo

et al. 2019

BioMed Research International

View full text Add to dashboard Cite

Background. The relationship between vitamin D level and NAFLD has not been investigated in children and adolescents. We performed a meta-analysis of published observational studies to assess this association between vitamin D levels (measured as serum 25-hydroxy vitamin D [25(OH)D]) and NAFLD in this age group. Methods. Relevant studies conducted before May 20, 2018, were identified from the following electronic databases: PubMed, the Cochrane Library, Embase, and the Chinese CNKI databases. The quality of the included studies was evaluated using the Newcastle Ottawa Scale, and associations between vitamin D levels and NAFLD were estimated using standardised mean differences (SMD) and 95% confidence interval (CI). Subgroup and sensitivity analysis were used to identify sources of heterogeneity, and publication bias was evaluated using funnel plots. Results. Eight articles were included in this meta-analysis. A significant difference was observed between low 25(OH)D levels and NAFLD in children and adolescents (SMD = -0.59, 95%CI = -0.98, -0.20, P < 0.01). Subgroup analysis revealed no differences in the study type, geographic location, BMI, and age subgroups. Conclusions. Low vitamin D levels were associated with NAFLD in children and adolescents.

show abstract

“…Observational studies found that vitamin D levels decreased in NAFLD. [ 31 32 33 ] Whether vitamin D deficiency is a contributing factor to NAFLD remains unclear. Some studies showed that low vitamin D levels were associated with the presence of NAFLD, suggesting that vitamin D may be a target for the treatment of NAFLD and NASH.…”

Section: Discussionmentioning

confidence: 99%

Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver

Sheng

Shi

Liu

et al. 2023

Saudi Journal of Gastroenterology

View full text Add to dashboard Cite

Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown. The aim of this study was to investigate whether levels of 25(OH)D are associated with risk of NAFLD, using a two-sample Mendelian randomization (MR). Methods: Data from a recent large vitamin D genome-wide association study (GWAS) on 417,580 Europeans were utilized, and the largest published histology-based NAFLD GWAS study (1,483 cases and 17,781 healthy controls) for genetic variants predicted to cause NAFLD were searched. All genetic datasets for the MR analyses were obtained using publicly available summary statistics based on individuals of European ancestry from the MR-Base and NHGRI-EBI GWAS Catalog database. Inverse-variance weighted (IVW) MR approach was used to estimate causal effects in the main analysis, complemented by 4 additional methods to control for pleiotropy. Sensitivity analyses were conducted to verify whether heterogeneity and pleiotropy can bias the MR results. Results: The MR analysis did not provide strong evidence for the causal association of circulating 25(OH)D with NAFLD by IVW method (OR = 0.746, 95%CI 0.517–1.078; P = 0.119). The results were consistent using four other MR methods. Sensitivity analysis using all different analytical approaches yielded similar results. There was no evidence for pleiotropy (MR-Egger intercept: −0.0003758, P = 0.970). The replication process also showed consistent results using IVW method ( P = 0.710). Conclusion: This study indicates that serum 25(OH)D levels did not possess an obvious effect on the risk of NAFLD. The associations in previous studies may be due to residual confounding or reverse causation.

show abstract

Assessment of Vitamin D status in a group of Egyptian children with non alcoholic fatty liver disease (multicenter study)

Cited by 12 publications

References 39 publications

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

High dose vitamin D supplementation is associated with an improvement in serum markers of liver function

The Level of Vitamin D in Children and Adolescents with Nonalcoholic Fatty Liver Disease: A Meta-Analysis

Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver

Contact Info

Product

Resources

About