Assessment of wastewater-borne pharmaceuticals in tissues and body fluids from riverine fish

Manjarrés-López, Diana P.; Peña-Herrera, J.M.; Benejam, Lluís; Montemurro, Nicola; Pérez, Sandra

doi:10.1016/j.envpol.2023.121374

Cited by 16 publications

(3 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KTP can be absorbed from the surrounding environment and gradually accumulated in the tissues of these organisms, potentially resulting in higher concentrations as it progresses up the food chain. For instance, KTP has been detected in the heart of Thinlip mullet ( Liza ramada ), a river fish that inhabits environments heavily impacted by WWTP effluents ( Manjarrés-López et al, 2023 ). Furthermore, KTP has been found in the tissues of marine fish, such as Atlantic salmon, Atlantic Sea wolf, and Rainbow trout, at concentrations ranging from 80 to 120 μg/kg ( Pashaei et al, 2022a ).…”

Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises concerns for ecological well-being. It poses a growing threat due to its racemic mixture, enantiomers, and transformation products, which have ecotoxicological effects on various organisms, including invertebrates, vertebrates, plants, and microorganisms. Furthermore, ketoprofen is bioaccumulated and biomagnified throughout the food chain, threatening the ecosystem function. Surprisingly, despite these concerns, ketoprofen is not currently considered a priority substance. While targeted eco-pharmacovigilance for ketoprofen has been proposed, data on ketoprofen as a pharmaceutical contaminant are limited and incomplete. This review aims to provide a comprehensive summary of the most recent findings (from 2017 to March 2023) regarding the global distribution of ketoprofen in the environment, its ecotoxicity towards aquatic animals and plants, and available removal methods. Special emphasis is placed on understanding how ketoprofen affects microorganisms that play a pivotal role in Earth’s ecosystems. The review broadly covers various approaches to ketoprofen biodegradation, including whole-cell fungal and bacterial systems as well as enzyme biocatalysts. Additionally, it explores the potential of adsorption by algae and phytoremediation for removing ketoprofen. This review will be of interest to a wide range of readers, including ecologists, microbiologists, policymakers, and those concerned about pharmaceutical pollution.

show abstract

Section: Ecotoxic Effects Of Ketoprofenmentioning

confidence: 99%

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Tyumina,

Subbotina,

Polygalov

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

“…Nevertheless, SWATH acquisition is a more attractive data-independent acquisition (DIA) strategy that allows to identify and quantify every detectable compound in a sample in one single run, eliminating the risk of missing a relevant analyte. Every detectable analyte in the sample is fragmented giving a complete MS and MS/MS picture of every detectable in the sample which can be used either for quantification or a posteriori for retrospective analysis to identify new unidentified or unexpected compounds (Manjarrés-López et al 2023 ). To improve the selectivity of the SWATH, the entire m/z mass detection range (99.5 to 950 m/z) in which ions are distributed along run time was divided into ten sequential Q 1 variable windows.…”

Section: Resultsmentioning

confidence: 99%

Evaluation of different QuEChERS-based methods for the extraction of 48 wastewater-derived organic contaminants from soil and lettuce root using high-resolution LC-QTOF with MRMHR and SWATH acquisition modes

Montemurro,

Manasfi,

Chiron

et al. 2024

Environ Sci Pollut Res

Self Cite

View full text Add to dashboard Cite

The reuse of treated wastewater in agriculture is an important route of introducing a large number of organic contaminants into the agroecosystem. In this study, a modified QuEChERS-based approach was developed for rapid, simple, and simultaneous extraction of 48 organic wastewater-derived contaminants from soil and lettuce root. Twenty-two different (modification) scenarios of the known (or original) QuEChERS method have been tested, in order to obtain best and well-compromised recoveries for all target compounds for soil and roots. Finally, a common method was chosen for both matrices consisting of a single extraction step using EDTA-Mcllvaine buffer and the unbuffered Original QuEChERS salts. Method performance was accomplished by liquid chromatography coupled with high-resolution mass spectrometry on a QToF-MS system using two different acquisition modes, the ultra-fast high-resolution multiple reaction monitoring (MRMHR) mode and the innovative Sequential Window Acquisition of All Theoretical Fragment-Ion (SWATH) mode. Performance characterization was evaluated in terms of recovery, linearity, intra-day precision, method detection limits (MDLs), method quantification limits (MQLs), and matrix effect (ME). Recoveries in MRMHR mode ranged from 63 to 111% and 54 to 104% for lettuce root and soil, respectively, for most of compounds in MRMHR mode and from 56 to 121% and 54 to 104% for lettuce root and soil, respectively, for most of compounds in SWATH. Whereas, MQLs ranged from 0.03 to 0.92 ng g−1 in MRMHR and from 0.03 to 82 ng g−1 in SWATH for lettuce root, and from 0.02 to 0.44 ng g−1 in MRMHR and 0.02 to 0.14 ng g−1 in SWATH for soil. The method was then applied to follow the target compounds in soil and lettuce root, where the system lettuce-soil was irrigated with treated wastewater under real greenhouse conditions. Five and 17 compounds were detected in lettuce root and soil, respectively. Graphical Abstract

show abstract

“…These chemicals include a wide range of medications, comprising antibiotics and antidepressants, and are able to enter the waterways through various routes, such as wastewater discharge, improper disposal, and excretion by humans and animals [ 165 ]. Fish can ultimately be exposed to pharmaceutical compounds directly from the water or through the food web, also leading to the bioaccumulation of these chemicals in their tissues [ 166 , 167 ]. Moreover, another cause of pollution in the aquatic ecosystem is represented nowadays by the intensive use of pesticides because of the widespread use of this class of compounds, primarily in agriculture, to control pests or unwanted organisms, such as invasive weeds, insects, and fungi.…”

Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

View full text Add to dashboard Cite

The Mediterranean region is facing several environmental changes and pollution issues. Teleosts are particularly sensitive to these challenges due to their intricate reproductive biology and reliance on specific environmental cues for successful reproduction. Wild populations struggle with the triad of climate change, environmental contamination, and overfishing, which can deeply affect reproductive success and population dynamics. In farmed species, abiotic factors affecting reproduction are easier to control, whereas finding alternatives to conventional diets for farmed teleosts is crucial for enhancing broodstock health, reproductive success, and the sustainability of the aquaculture sector. Addressing these challenges involves ongoing research into formulating specialized diets, optimizing feeding strategies, and developing alternative and sustainable feed ingredients. To achieve a deeper comprehension of these challenges, studies employing model species have emerged as pivotal tools. These models offer advantages in understanding reproductive mechanisms due to their well-defined physiology, genetic tractability, and ease of manipulation. Yet, while providing invaluable insights, their applicability to diverse species remains constrained by inherent variations across taxa and oversimplification of complex environmental interactions, thus limiting the extrapolation of the scientific findings. Bridging these gaps necessitates multidisciplinary approaches, emphasizing conservation efforts for wild species and tailored nutritional strategies for aquaculture, thereby fostering sustainable teleost reproduction in the Mediterranean.

show abstract

Assessment of wastewater-borne pharmaceuticals in tissues and body fluids from riverine fish

Cited by 16 publications

References 69 publications

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal

Evaluation of different QuEChERS-based methods for the extraction of 48 wastewater-derived organic contaminants from soil and lettuce root using high-resolution LC-QTOF with MRMHR and SWATH acquisition modes

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Contact Info

Product

Resources

About