Assessment of White Matter Integrity after Pediatric Traumatic Brain Injury

Wright, Kacie L; Hopkins, Ramona O.; Robertson, Frank E.; Bigler, Erin D.; Taylor, H. Gerry; Rubin, Kenneth H.; Vannatta, Kathryn; Stancin, Terry; Yeates, Keith Owen

doi:10.1089/neu.2019.6691

Cited by 7 publications

(5 citation statements)

References 62 publications

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“…NeuroQuant V R generally has been found to have good to excellent reliability with FreeSurfer by our group, 33,34 and others. 30,35,40,74 Given the multiple studies showing good intermethod reliability and other types of reliability for NeuroQuant V R , 8,75,76 we believe that it is likely that the results of the current study would show good reliability with results from studies using programs like FreeSurfer. Nevertheless, it will be important to test this idea directly.…”

Section: Limitationsmentioning

confidence: 73%

“…These include multiple studies that found that NeuroQuant V R is reliable for measuring brain volume in normal subjects, patients with TBI, and other neuropsychiatric patients 8,[29][30][31][32][33][34][35] and valid for assessing brain volume in patients with TBI. 4,5,8,12,16,19,25,33,[35][36][37][38][39][40][41] Neuroquant V R automated brain MRI segmentation. The brain MRI grayscale images for each patient and NeuroGage V R normal control V R were uploaded to the NeuroQuant V R server, which processed and analyzed the brain imaging data.…”

Section: Brain Imaging and Volume Measurementmentioning

confidence: 99%

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Patients with chronic mild or moderate traumatic brain injury have abnormal longitudinal brain volume enlargement more than atrophy

Ross

Seabaugh

et al. 2021

Journal of Concussion

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Introduction Many studies have found brain atrophy in patients with traumatic brain injury (TBI), but most of those studies examined patients with moderate or severe TBI. A few recent studies in patients with chronic mild or moderate TBI found abnormally large brain volume. Some of these studies used NeuroQuant®, FDA-cleared software for measuring MRI brain volume. It is not known if the abnormal enlargement occurs before or after injury. The purpose of the current study was to test the hypothesis that it occurs after injury. Methods 55 patients with chronic mild or moderate TBI were compared to NeuroQuant® normal controls ( n > 4000) with respect to MRI brain volume change from before injury (time 0 [t0], estimated volume) to after injury (t1, measured volume). A subset of 36 patients were compared to the normal controls with respect to longitudinal change of brain volume after injury from t1 to t2. Results The patients had abnormally fast increase of brain volume for multiple brain regions, including whole brain, cerebral cortical gray matter, and subcortical regions. Discussion This is the first report of extensive abnormal longitudinal brain volume enlargement in patients with TBI. In particular, the findings suggested that the previously reported findings of cross-sectional brain volume abnormal enlargement were due to longitudinal enlargement after, not before, injury. Abnormal longitudinal enlargement of the posterior cingulate cortex correlated with neuropathic headaches, partially replicating a previously reported finding that was associated with neuroinflammation.

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Section: Limitationsmentioning

confidence: 73%

Section: Brain Imaging and Volume Measurementmentioning

confidence: 99%

Patients with chronic mild or moderate traumatic brain injury have abnormal longitudinal brain volume enlargement more than atrophy

Ross

Seabaugh

et al. 2021

Journal of Concussion

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“…Vanier et al (Vanier et al, 2020) divided a sample of mild TBI patients into those with and without MRI brain abnormalities, including hippocampal atrophy or asymmetry based on NeuroQuant R analyses; patients with MRI abnormalities had slower recovery from balance and cognitive deficits. In a study of pediatric patients with TBI, Wright et al found that increased volumes of white matter hyperintensities measured by NeuroQuant R correlated with decreased cognitive processing speed (Wright et al, 2020). And longitudinal enlargement of the posterior cingulate gyrus was associated with the diagnosis of neuropathic headaches in patients with chronic mild or moderate TBI (Ross et al, 2021); this finding partially replicated an earlier finding by another group (Niu et al, 2020).…”

Section: Validity Of Neuroquantmentioning

confidence: 82%

“…NeuroQuant R and the Scheltens scale (visual evaluation of medial temporal lobe atrophy) correlated highly and were similarly useful for distinguishing patients with Alzheimer's disease from patients without dementia (Persson et al, 2018b). In a study of pediatric patients with TBI, Wright et al found that Scheltens ratings of white matter hyperintensities (WMHs) had good to excellent agreement with WMH volumes for NeuroQuant R (Wright et al, 2020); also NeuroQuant R and FreeSurfer total white matter volumes correlated significantly and had fair agreement. Brinkmann et al found that NeuroQuant-derived hippocampal volumes were more reproducible than hand-traced volumes (Brinkmann et al, 2019).…”

Section: Reliability Of Neuroquant R and Neurogage Rmentioning

confidence: 99%

“…Therefore, NeuroQuant R is better suited for routine clinical application, although it is still quite useful for research. NeuroQuant R has been found to have good to excellent reliability with FreeSurfer (Kovacevic et al, 2009;Ochs et al, 2015;Reid et al, 2017;Ross et al, 2018a;Chung et al, 2020;Wright et al, 2020); for a review of studies examining their reliability see section "Reliability of NeuroQuant R and NeuroGage R " below.…”

Section: Intro To Freesurfermentioning

confidence: 99%

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Updated Review of the Evidence Supporting the Medical and Legal Use of NeuroQuant® and NeuroGage® in Patients With Traumatic Brain Injury

Ross

Seabaugh

et al. 2022

Front. Hum. Neurosci.

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Over 40 years of research have shown that traumatic brain injury affects brain volume. However, technical and practical limitations made it difficult to detect brain volume abnormalities in patients suffering from chronic effects of mild or moderate traumatic brain injury. This situation improved in 2006 with the FDA clearance of NeuroQuant®, a commercially available, computer-automated software program for measuring MRI brain volume in human subjects. More recent strides were made with the introduction of NeuroGage®, commercially available software that is based on NeuroQuant® and extends its utility in several ways. Studies using these and similar methods have found that most patients with chronic mild or moderate traumatic brain injury have brain volume abnormalities, and several of these studies found—surprisingly—more abnormal enlargement than atrophy. More generally, 102 peer-reviewed studies have supported the reliability and validity of NeuroQuant® and NeuroGage®. Furthermore, this updated version of a previous review addresses whether NeuroQuant® and NeuroGage® meet the Daubert standard for admissibility in court. It concludes that NeuroQuant® and NeuroGage® meet the Daubert standard based on their reliability, validity, and objectivity. Due to the improvements in technology over the years, these brain volumetric techniques are practical and readily available for clinical or forensic use, and thus they are important tools for detecting signs of brain injury.

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