Assessment of whole-body MRI including diffusion-weighted sequences in the initial staging of breast cancer patients at high risk of metastases in comparison with PET-CT: a prospective cohort study

Hottat, Nathalie; Badr, Dominique A.; Ghanem, Meriem Ben; Besse‐Hammer, Tatiana; Vansteelandt, Catherine; Lecomte, Sophie; Khaled, Chirine; Grove, Veerle De; Wehbe, Georges Salem; Cannie, Mieke; Jani, Jacques

doi:10.1007/s00330-023-10060-0

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…MRI, used in PET/MRI hybrid imaging, offers superior soft-tissue contrast. The DWI sequence has proven effective for distinguishing bone metastases from both solid tumors and hematological malignancies (Pasoglou et al 2015 ; Dimopoulos et al 2015 ; Hottat et al 2024 ). DWI also allows for quantifying lesion cellularity through ADC maps and numerous studies have demonstrated its value in bone metastases (Costelloe et al 2021 ; Eveslage et al 2023 ; Perez-Lopez et al 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Outcome prediction of SSTR-RADS-3A and SSTR-RADS-3B lesions in patients with neuroendocrine tumors based on 68Ga-DOTATATE PET/MR

Gao,

Zhou,

Liu

et al. 2024

J Cancer Res Clin Oncol

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Purpose Somatostatin receptor (SSTR)-targeted PET imaging has emerged as a common approach to evaluating those patients with well-differentiated neuroendocrine tumors (NETs). The SSTR reporting and data system (SSTR-RADS) version 1.0 provides a means of categorizing lesions from 1 to 5 according to the likelihood of NET involvement, with SSTR-RADS-3A (soft-tissue) and SSTR-RADS-3B (bone) lesions being those suggestive of but without definitive NET involvement. The goal of the present study was to assess the ability of 68Ga-DOTATATE PET/MR imaging data to predict outcomes for indeterminate SSTR-RADS-3A and 3B lesions. Methods NET patients with indeterminate SSTR-RADS-3A or SSTR-RADS-3B lesions who underwent 68Ga-DOTATATE PET/MR imaging from April 2020 through August 2023 were retrospectively evaluated. All patients underwent follow-up through December 2023 (median, 17 months; (3–31 months)), with imaging follow-up or biopsy findings ultimately being used to classify lesions as malignant or benign. Lesion maximum standardized uptake value (SUVmax) along with minimum and mean apparent diffusion coefficient (ADCmin and ADCmean) values were measured and assessed for correlations with outcomes on follow-up. Results In total, 33 indeterminate SSTR-RADS-3 lesions from 22 patients (19 SSTR-RADS-3A and 14 SSTR-RADS-3B) were identified based upon baseline 68Ga-DOTATATE PET/MR findings. Over the course of follow-up, 16 of these lesions (48.5%) were found to exhibit true NET positivity, including 9 SSTR-RADS-3A and 7 SSTR-RADS-3B lesions. For SSTR-RADS-3A lymph nodes, a diameter larger than 0.7 cm and an ADCmin of 779 × 10−6mm2/s or lower were identified as being more likely to be associated with metastatic lesions. Significant differences in ADCmin and ADCmean were identified when comparing metastatic and non-metastatic SSTR-RADS-3B bone lesions (P < 0.05), with these parameters offering a high predictive ability (AUC = 0.94, AUC = 0.86). Conclusion Both diameter and ADCmin can aid in the accurate identification of the nature of lesions associated with SSTR-RADS-3A lymph nodes, whereas ADCmin and ADCmean values can inform the accurate interpretation of SSTR-RADS-3B bone lesions.

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Section: Discussionmentioning

confidence: 99%

Outcome prediction of SSTR-RADS-3A and SSTR-RADS-3B lesions in patients with neuroendocrine tumors based on 68Ga-DOTATATE PET/MR

Gao,

Zhou,

Liu

et al. 2024

J Cancer Res Clin Oncol

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DWI Outside the Brain

Papa,

Santonocito,

Gatti

et al. 2024

A Practical Guide to Advanced Diffusion MRI

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Comparative Analysis of Whole-Body Diffusion-Weighted Imaging and PET/CT in Metastasis Detection: A Prospective Study

Akdal Dolek,

Sozmen Ciliz,

Ozdemir

et al. 2024

Cureus

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IntroductionTumor staging is essential for determining treatment strategies and predicting prognosis in cancer patients. Accurate imaging techniques are critical for staging, metastasis screening, treatment response assessment, and recurrence detection. ObjectiveIn this prospective study, we aimed to compare the sensitivity of whole-body diffusion-weighted imaging (WB-DWI) with positron emission tomography/computed tomography (PET/CT) in detecting metastases. Materials and methodsTwenty-one patients with metastatic cancer disease confirmed by PET/CT examination were prospectively examined with WB-DWI. PET/CT scans were performed using 18-fluorodeoxyglucose (18F-FDG). To assess and localize metastatic lesions, each case was evaluated at 18 different sites, including the skeletal system, visceral areas, and lymph nodes. Lesions were localized and counted using both radiological modalities. ResultsTwenty-one patients with metastatic disease were included (12 men, 9 women; mean age 58 years). All patients underwent PET/CT followed by WB-DWI. The average interval between PET/CT and WB-DWI was 22.5 days. Of the 378 regions examined, PET/CT detected 68 metastases, while WB-DWI detected 64 metastases. Liver metastases were detected in 2 out of 3 patients by WB-DWI. WB-DWI demonstrated substantial agreement with PET/CT in detecting liver metastases (κ (Cohen's kappa) = 0.77, p < .001) and lung metastases (κ = 0.74, p < .001). All adrenal gland and soft tissue metastases were detected by WB-DWI, with perfect agreement (κ = 1, p < .001). WB-DWI detected 31 metastatic lymph nodes identified by PET/CT, also with perfect agreement (κ = 1, p < .001). ConclusionWB-DWI offers significant advantages over PET/CT, including reduced imaging time, no radiation exposure, and lower costs. WB-DWI demonstrates comparable sensitivity to PET/CT in metastasis screening, suggesting the potential to reduce PET/CT usage with further improvements in DWI parameters and MRI technology.

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Assessment of whole-body MRI including diffusion-weighted sequences in the initial staging of breast cancer patients at high risk of metastases in comparison with PET-CT: a prospective cohort study

Cited by 3 publications

References 35 publications

Outcome prediction of SSTR-RADS-3A and SSTR-RADS-3B lesions in patients with neuroendocrine tumors based on 68Ga-DOTATATE PET/MR

Outcome prediction of SSTR-RADS-3A and SSTR-RADS-3B lesions in patients with neuroendocrine tumors based on 68Ga-DOTATATE PET/MR

DWI Outside the Brain

Comparative Analysis of Whole-Body Diffusion-Weighted Imaging and PET/CT in Metastasis Detection: A Prospective Study

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