Assessment of work instability in spondyloarthritis: a cross-sectional study using the ankylosing spondylitis work instability scale

Fabreguet, Isabelle; Koumakis, Eugénie; Burki, Vincent; Durnez, Anne; Elhaï, Muriel; Meyer, Magali; Paternotte, Simon; Payet, Judith; Roure, Fanny; Fautrel, Bruno; Dougados, Maxime; Gossec, Laure

doi:10.1093/rheumatology/ker319

Cited by 20 publications

(13 citation statements)

References 16 publications

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“…Compared with joint involvement in rheumatoid arthritis (RA), inflammation in SpA mainly takes the form of enthesitis and commonly results in bone formation and ankylosis rather than bone erosion (Marzo-Ortega et al 2002 ; McGonagle et al 2014 ). Nevertheless, the consequences of these changes also lead to functional limitations, poor quality of life, loss of working hours, and even decreased life expectancy (Braun and Pincus 2002 ; Fabreguet et al 2012 ). Prognosis is often poorer because of the delay in diagnosis, especially in patients with isolated axial involvement (Rudwaleit et al 2005 ).…”

Section: Introductionmentioning

confidence: 99%

Vasoactive Intestinal Peptide in Early Spondyloarthritis: Low Serum Levels as a Potential Biomarker for Disease Severity

et al. 2015

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Spondyloarthritis (SpA) is a family of inflammatory diseases sharing clinical, genetic, and radiological features. While crucial for tailoring early interventions, validated prognostic biomarkers are scarce in SpA. We analyze the correlation between serum levels of vasoactive intestinal peptide (VIP) and disease activity/severity in patients with early chronic inflammatory back pain. The study population comprised 54 patients enrolled in our early chronic inflammatory back pain register. We collected demographic information, clinical data, laboratory data, and imaging findings. VIP levels were measured by enzyme immunoassay in serum samples from 162 visits. The association between independent variables and VIP levels was analyzed using longitudinal multivariate analysis nested by patient and visit. No significant differences were observed in VIP levels between these two groups. Lower levels of VIP were significantly associated with a higher Bath Ankylosing Spondylitis Disease Activity Index (BASFI) score, presence of bone edema in magnetic resonance imaging (MRI) scan, and lower hemoglobin levels. Coexistence of cutaneous psoriasis was independently associated with lower VIP levels, and similar trend was observed for enthesitis. We conclude that SpA patients with low serum VIP levels had worse 2-year disease outcome, suggesting that serum VIP levels could be a valid prognostic biomarker.

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Section: Introductionmentioning

confidence: 99%

Vasoactive Intestinal Peptide in Early Spondyloarthritis: Low Serum Levels as a Potential Biomarker for Disease Severity

et al. 2015

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“…Involvement of peripheral joints, of hips or of the cervical spine, has a significant effect on functional capacity. In other studies, hip-involvement or impairment of specific indexes for AS were also highly associated with work-disability [7,[15][16][17].…”

Section: Discussionmentioning

confidence: 69%

Development of a prognostic score for work disability in Romanian patients with ankylosing spondylitis

Oancea

Mihai

Gherman

et al. 2014

Disability and Rehabilitation

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Work disability is an important outcome in AS, determined by numerous variables but highly dependent on the national characteristics of economy, social security and healthcare system. The prognostic score for work disability in AS not only contains medical but also socio-demographic and work-related factors and is expected to be a useful tool for specialists to guide the tertiary prevention-oriented rehabilitation measures. Our study suggests the prognostic score to be comprehensive, useful and a reliable method to assess the risk of work disability in AS.

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“…Furthermore, the physical limitations of axSpA can affect basic activities such as eating, washing, dressing, and social activities, as well as the ability to work. Cross‐sectional studies have reported that 10.5%‐32% of patients were forced to give up their jobs due to the disease, with limitations to work ability described by about half of all respondents . Taken together, the evidence shows that axSpA patients face significant challenges, and the main goal of treatment should therefore be to restore and preserve quality of life and normal function for patients as much as possible.…”

Section: Resultsmentioning

confidence: 99%

Taiwan Rheumatology Association consensus recommendations for the management of axial spondyloarthritis

et al. 2019

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Aim:To establish guidelines for the clinical management of axial spondyloarthritis that take into account local issues and clinical practice concerns for Taiwan. Method:Overarching principles and recommendations were established by consensus among a panel of rheumatology and rehabilitation experts, based on analysis of the most up-to-date clinical evidence and the clinical experience of panelists. AllOverarching Principles and Recommendations were graded according to the standards developed by the Oxford Centre for Evidence Based Medicine, and further evaluated and modified using the Delphi method. Results:The guidelines specifically address issues such as local medical considerations, National Health Insurance reimbursement, and management of extra-articular manifestations.Conclusion: It is hoped that this will help to optimize clinical management outcomes for axial spondyloarthritis in Taiwan. K E Y W O R D Sankylosing spondylitis, axial spondyloarthritis, extra-articular manifestation, IL-17 inhibitor, non-radiographic axial spondyloarthritis, spinal fracture, TNF inhibitor

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Assessment of work instability in spondyloarthritis: a cross-sectional study using the ankylosing spondylitis work instability scale

Abstract: Work instability was found to be high and its main determinant was patient's global assessment. The predictive validity of the AS-WIS in terms of job retention should be further assessed.

Cited by 20 publications

References 16 publications

Vasoactive Intestinal Peptide in Early Spondyloarthritis: Low Serum Levels as a Potential Biomarker for Disease Severity

Vasoactive Intestinal Peptide in Early Spondyloarthritis: Low Serum Levels as a Potential Biomarker for Disease Severity

Development of a prognostic score for work disability in Romanian patients with ankylosing spondylitis

Taiwan Rheumatology Association consensus recommendations for the management of axial spondyloarthritis

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