Helicoidal schemes possessed by biological creatures possess high strength and stiffness. The adoption of the layup configurations possessed by these biological creatures is not fully explored. The present article aims to carry out the free vibration analysis of biological-inspired laminated composite (B-ILC) plates having helicoidal layup. The analysis is carried out using higher-order zigzag theory (HOZT) as due to the presence of several layers, the HOZT can predict the behavior accurately compared to the shear deformation theory. Based on Hamilton’s principle, the governing equations are worked out and analyzed using the finite element method. The influence of boundary conditions, geometric properties, number of layers, the skew angle of the plate, and material properties on the free vibration behavior are studied in detail.