PurposeThis article aims to assess risks related to the supply chain 5.0 digitalization. It aims to analyze interdependencies and causal relationships between critical digital supply chain 5.0 risks, emphasizing the need for proactive management to address emerging challenges.Design/methodology/approachThrough an extensive literature review and expert judgment, risks related to supply chain 5.0 digitalization are identified. An integrated approach for risk assessment is employed, where the Analytic Hierarchy Process (AHP) is utilized to prioritize these risks. Subsequently, the Decision-Making Trial and Evaluation Laboratory (DEMATEL) method is employed to investigate cause-and-effect relationships among the identified top 10 risks. This comprehensive analysis forms the basis for informed strategic management decision-making.FindingsThe analysis identifies significant influences of “Dependence on technology,” “Complexity”, “Potential system failures”, and “Cyber security” while “Environmental impact” and “Socio-economic disparities” emerge as prominent risks in supply chain 5.0 digitalization. These findings offer actionable insights for management decision-making, guiding the formulation of strategies to address and mitigate critical risks.Practical implicationsThe proposed integrated approach (AHP-DEMATEL) provides valuable insights for managers to effectively mitigate digital supply chain 5.0 risks and strategically respond to disruptions. By prioritizing risks, organizations can allocate resources efficiently and address the most critical challenges first, minimizing long-term damage to resilience. Embracing this approach enables practitioners to enhance overall supply chain resilience, guiding key management decisions for the development of sustainable and adaptive strategies.Originality/valueThis paper marks the first comprehensive attempt to assess supply chain 5.0 digitalization risks using decision-making methods like AHP and DEMATEL. The integrated approach contributes novel insights to the field of supply chain risk management, specifically aiding management decision-making in the face of digitalization challenges.