Assignment by Deletion of Human Red Cell Acid Phosphatase Gene Locus to the Short Arm of Chromosome 2

Assignment of three human gene loci to regions of chromosome 2

“…Clone 02, which effectively had all of the chromosome 2 material present did not express IDH-1 suggesting that this locus is at 2 q ll and that it was deleted or rendered nonfunctional during the process of breakage and reunion. (3) Ferguson-Smith et al 5 assigned the ACPi locus to the 2p23->2pter region on the basis of hemizygosity of the ACPi locus in a patient carrying a derivative chromosome 2 from which 2p23-*2pter had been deleted. Subclone 19 carried a deletion for the 2p23->-2pter region with, so far as can be determined by means of the banding technique, a break point in a position identical to that reported by F erguson-Smith et al, and yet it expressed human ACPi.…”

Duplication within chromosome 5q characterized by fluorescence in situ hybridization

“…Most cases were the result of an inherited unbalanced translocation, and therefore do not have pure partial trisomy for 5q [Ferguson-Smith et al, 1973;Jalbert et al, 1975;Osztovics and Kiss, 1975;Watanabe et al, 1977;Bartsch-Sandhoff and Liersch, 1977;Zabel et al, 1978;Curry et al, 1979;Jones et al, 1979;Rodewald et al, 1980]. There were three cases of apparently pure duplications of 5q, whose breakpoints had been determined cytogenetically [Kessel and Pfeiffer, 1979;Gilgenkrantz et al, 1981;Martin et al, 1985].…”

The gene map and genome organization

“…The contribution of cytogenetics to gene mapping was initiated by the assignment of the gene for red cell acid phosphatase to the tip of chromosome 2 (7). Deletion mapping culminated with the localization of the retinoblastoma gene on 13q14 (8) and the cloning of the Duchenne muscular dystrophy gene on Xp21 (9).…”