Assignment of 1H and 13C NMR resonances of some isoquinoline alkaloids

Janssen, R. H. A. M.; Lousberg, R. J. J. C.; Wijkens, Peter; Kruk, C.; Theuns, Hubert G.

doi:10.1016/s0031-9422(00)98100-7

Cited by 21 publications

(8 citation statements)

References 11 publications

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“…Their 1 H and 13 C NMR spectral data measured in the same NMR solvent were in good agreement with the reported data (Hughes et al, 1976;Janssen et al, 1989;Saito et al, 2004). The structure of dehydrocorydaline was readily determined by a combination of spectroscopic analysis and comparison with the literature data (Slavik and Slavikova, 1979;Janssen et al, 1989;Sener et al, 1992). Although the dehydrocorydaline was a well-known alkaloid, NMR spectral full assignment for this compound has never been reported until now.…”

Section: Discussionsupporting

confidence: 85%

Expression of inducible nitric oxide synthase by Corydalis turtschaninovii on interferon-γ stimulated macrophages

Rim

Chung

et al. 2009

Journal of Ethnopharmacology

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Section: Discussionsupporting

confidence: 85%

Expression of inducible nitric oxide synthase by Corydalis turtschaninovii on interferon-γ stimulated macrophages

Rim

Chung

et al. 2009

Journal of Ethnopharmacology

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“…The known alkaloids (−)-tetrahydropalmatine (3) [21,28], (−)-corynoxidine (4) [29], (+)-1-nitroapocavidine (5) [3], (+)-cavidine (6) [26,27], (+)-thalictrifoline (7) [26,27,30], berberine (8) [31,32], palmatine (9) [33], dehydrocavidine (10) [34], sanguinarine (11) [31], and 8-acetonyldihydrochelerythrine (12) [35] were determined by comparison of their spectral data with those in the literature. The inhibitory activity of all compounds against AChE, BuChE, and canine parvovirus were evaluated.…”

Section: Resultsmentioning

confidence: 99%

Bioactive Isoquinoline Alkaloids fromCorydalis saxicola

Huang¹,

Bi²,

Sun³

et al. 2011

Planta Med

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Twelve isoquinoline alkaloids including two new nitro-containing tetrahydroprotoberberines, (-)-2,9-dihydroxyl-3,11-dimethoxy-1,10-dinitrotetrahydroprotoberberine (1) and (+)-4-nitroisoapocavidine (2), were isolated from the whole plant of Corydalis saxicola Bunting. The structures of the new compounds were established by spectroscopic analysis and chemical evidence. The inhibitory activity of these isolates against cholinesterase and canine parvovirus were evaluated. Compounds 1 and 1A, (+)-1-nitroapocavidine (5), berberine (8), palmatine (9), dehydrocavidine (10), and sanguinarine (11) showed potent inhibitory activity against acetylcholinesterase with IC(50) values of less than 10 µM, while only compound 1 possessed weak activity against canine parvovirus. Structure-activity studies demonstrated that the nitro substituents at ring A in the tetrahydroprotoberberines led to an increase in the anti-acetylcholinesterase activity.

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“…Compounds 1-4 were identified to be 8-hydroxydihydrochelerythrine, 14) 8-hydroxydihydrosanguinarine, 15) noroxyhydrastinine, 16) and berberine, 17) respectively, which mass and NMR spectral data Vol. 29, No.…”

Section: Resultsmentioning

confidence: 99%