Assignment of the mouse &lt;i&gt;Rbpsuh&lt;/i&gt; gene to chromosome 5 and one processed pseudogene &lt;i&gt;Rbpsuh-rs3&lt;/i&gt; to chromosome 6

Bs, Klein; Himmelbauer, Heinz; Zechner, Ulrich; Riemann, Michael; Liptay, Susanne; Hameister, Horst; Schmid, Ralph A.

doi:10.1159/000015554

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…One of the only two known genes in the Obrq3b interval, AC158680, is a known pseudogene of Rbpsuh (Klein et al 2000) and was therefore not further evaluated. The second gene, Cntnap2, spans 2.2 Mb of genomic DNA and is involved in the localization of voltage-gated potassium channels within the nervous system (Poliak et al 1999).…”

Section: Resultsmentioning

confidence: 99%

The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity

et al. 2012

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Despite considerable effort, the identification of genes that regulate complex multigenic traits such as obesity has proven difficult with conventional methodologies. The use of a chromosome substitution strain-based mapping strategy based on deep congenic analysis over-came many of the difficulties associated with gene discovery and led to the finding that the juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity. The effects of a mild Cntnap2 mutation on body weight were highly dependent on genetic background, as both obesity-promoting and obesity-resistant effects of Cntnap2 were observed on different genetic backgrounds. The more severe effect of complete TAG1 deficiency, by decreasing food intake, completely prevented the weight gain normally associated with high-fat-diet feeding. Together, these studies implicate two novel proteins in the regulation of diet-induced obesity. Moreover, as juxtaparanodal proteins have previously been implicated in various neurological disorders, our results suggest a potential genetic and molecular link between obesity and diseases such as autism and epilepsy.

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Section: Resultsmentioning

confidence: 99%

The juxtaparanodal proteins CNTNAP2 and TAG1 regulate diet-induced obesity

et al. 2012

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“…Especially for physical gene mapping by fluorescence in situ hybridization (FISH) the Moloney murine leukemia virus-transformed suspension cell lines WMP1 and WMP2 turned out to be highly suited (2)(3)(4)(5)(6)(7)(8)(9). Those two cell lines carry 9 pairs of metacentric Robertsonian translocation chromosomes, including chromosomes 1-18, while the two chromosomes 19 and the sex chromosomes are the only acrocentric chromosomes (10).…”

Section: Introductionmentioning

confidence: 99%

Molecular cytogenetic characterization of the mouse cell line WMP2 by spectral karyotyping and multicolor banding applying murine probes

Karst

Трифонов²,

Romanenko³

et al. 2006

Int J Mol Med

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The Moloney murine leukemia virus-transformed suspension cell line WMP2 is derived from wild mice (Mus musculus) of the WMP/WMP strain. These mice carry nine pairs of metacentric Robertsonian translocation chromosomes. As the chromosomes of the wild-type mouse are all acrocentric, metaphase spreads of the WMP2 cells seam to be highly suited for physical gene mapping. Here we studied the WMP2 line using spectral karyotyping (SKY) combined with new established mouse specific multicolor banding (mcb) probes for the chromosomes X, 3, 4, 6 and 18. SKY revealed that the WMP2 cell line developed further four derivative chromosomes. After application of mcb five previously unrecognizable intrachromosomal rearrangements with 9 breakpoints were detected for the studied chromosomes.

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