Assisted Reproduction: Family, Fortunes and Fertility Clinics

Feasey, Rebecca

doi:10.1007/978-3-030-17787-4_3

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…To further realize the correlation between menopause and PLC prognosis, we defined women aged 50 and beyond as postmenopausal period. While natural menopause may occur from 45 to 55 of age[ 22 ], a recent cohort analysis including 36931 postmenopausal women indicated that the mean age at menopause is 50.2 years in Taiwan[ 23 ]. Propensity score matching and matching variables mentioned above were applied.…”

Section: Methodsmentioning

confidence: 99%

Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

Tseng¹,

Lin²,

Lai³

et al. 2021

WJH

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BACKGROUND While primary liver cancer (PLC) is one of the most common cancers around the world, few large-scale population-based studies have been reported that evaluated the clinical survival outcomes among peripartum and postmenopausal women with PLC. AIM To investigate whether peripartum and postmenopausal women with PLC have lower overall survival rates compared with women who were not peripartum and postmenopausal. METHODS The Taiwan National Health Insurance claims data from 2000 to 2012 was used for this propensity-score-matched study. A cohort of 40 peripartum women with PLC and a reference cohort of 160 women without peripartum were enrolled. In the women with PLC with/without menopause study, a study cohort of 10752 menopausal females with PLC and a comparison cohort of 2688 women without menopause were enrolled. RESULTS Patients with peripartum PLC had a non-significant risk of death compared with the non-peripartum cohort [adjusted hazard ratios (aHR) = 1.40, 95% confidence intervals (CI): 0.89-2.20, P = 0.149]. The survival rate at different follow-up durations between peripartum PLC patients and those in the non-peripartum cohort showed a non-significant difference. Patients who were diagnosed with PLC younger than 50 years old (without menopause) had a significant lower risk of death compared with patients diagnosed with PLC at or older than 50 years (postmenopausal) (aHR = 0.64, 95%CI: 0.61-0.68, P < 0.001). The survival rate of women < 50 years with PLC was significantly higher than older women with PLC when followed for 0.5 (72.44% vs 64.16%), 1 (60.57% vs 51.66%), 3 (42.92% vs 31.28%), and 5 year(s) (37.02% vs 21.83%), respectively ( P < 0.001). CONCLUSION Peripartum females with PLC have no difference in survival rates compared with those patients without peripartum. Menopausal females with PLC have worse survival rates compared with those patients without menopause.

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Section: Methodsmentioning

confidence: 99%