Assisted reproductive techniques in Latin America: The Latin American Registry, 2014

Abstract

INTRODUCTIONThe Latin American Registry of Assisted Reproduction (RLA) was established in 1990 as the first multinational and regional registry of assisted reproductive technology (ART). Yearly, a report is provided containing outcome of ART procedures performed by 159 institutions in 15 countries from Mexico in the north to Chile in the south. All institutions reporting to the registry need to be certified by an independent body before their data are accepted. The accreditation team consists of a clinician and a biologist from a different country who follows a pre-established protocol (www.redlara.com). The software developed for data registration and centralized reporting system has received several modifications over time. Since 2010, individualised case-by-case data are obtained, thus establishing the first cycle based multinational registry.The main objectives of RLA are: a) Disseminate information on ART procedures performed in Latin America; which serves as an external quality control to be used by institutions performing ART in the region and for other regions of the world; b) Monitor outcomes, as well as trends in safety and efficacy. Monitoring these two variables contribute to developing better health interventions and developing appropriate public policies; and c) Empower infertile couples in their capacity to evaluate risks and benefits when requesting ART treatments, and developing a robust database for epidemiological studies. It is often very difficult for an infertile and sometimes vulnerable person, to understand the risks and benefits involved in the treatment offered. Access to an objective and external database is often well received by infertile persons when deciding if treatment should be undertaken, such as how many embryos to transfer.This report corresponds to the 26 th edition of RLA. Previous reports, from 1990 to 1998, are available as printed copies; from 1999 to 2009 as PDF files, which can be downloaded from the web page www.redlara.com. Today, reports are published simultaneously in RBM Online, and in the JBRA Assisted Reproduction, the official journal of REDLARA.In this report we are communicating information on access, effectiveness, and perinatal outcomes of ART treatment initiated between 1 st January 2014 and 31 st December 2014, and babies born up to September 2015. MATERIAL AND METHODSData on ART were collected from 159 centres in fifteen countries in Latin America (Supplementary Table I), covering initiated autologous cycles of in vitro fertilisation (IVF), intra-cytoplasmic sperm injection (ICSI), frozen embryo transfer (FET), fresh oocyte donation (Fresh OD), frozen oocyte donation (FET OD), pre implantation genetic diagnosis and screening, registered together as PGD, and fertility preservation (FP). Data on intrauterine insemination using husband (IUI-H) and donor (IUI-D) semen is also provided.This report includes treatments started between 1 st January 2014 and 31 st December 2014. Data on pregnancy and neonatal outcomes are obtained from follow-up of the c...

Association between IVF/ICSI treatment and preterm birth and major perinatal outcomes among dichorionic‐diamnionic twin pregnancies: A seven‐year retrospective cohort study

“…Assisted reproductive technology (ART) has substantially improved and is increasingly used, especially in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI), so a considerable number of infertile couples are given the chance to have healthy infants. To maximize the success rate of live birth, double embryo transfers are routinely carried out, 1,2 which has resulted in the increasing incidence of multiple pregnancies. However, single embryo transfer has been promoted as the increased perinatal risks of maternal and neonatal complications among twin pregnancies are well known.…”

Atosiban improves the outcome of embryo transfer. A systematic review and meta-analysis of randomized and non-randomized trials

“…In spite of advanced progress in assisted reproduction technology (ART) over the past 20 years, the effectiveness of embryo transfer (ET) per cycle is still relatively low. In 2015, the delivery rate (DR) per ET in Latin America reached 25.6% in fresh autologous ET, and 36.8% when using donated eggs ( Zegers-Hochschild et al ., 2017a ; b ).…”

Intrauterine insemination as a primary viable option to infertile couples: evaluation of patients in a private center

“…In Denmark, for example, IUI treatments have been registered since 2007 (Malchau et al ., 2014). REDLARA, the Latin American Network of Assisted Reproduction, reported 6,250 cycles of IUI in 2013 with a birth rate per cycle of 14.9% (Zegers-Hochschild et al ., 2016). In Brazil, outcomes and indications of IUI are scarce.…”