Assisted reproductive technology (ART) in humans: Facts and uncertainties

Ménézo, Yves; Veiga, Anna; Pouly, J ­L

doi:10.1016/s0093-691x(99)00260-5

Cited by 47 publications

(8 citation statements)

References 48 publications

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“…The human and bovine are single ovulators and there are close similarities between human and bovine ovarian function and oocyte characteristics, in contrast to major differences in ovarian physiology and reproductive function between rodents and humans [26]. Bovine and human embryos are remarkably similar with respect to microtubule timing of genome activation, metabolic requirements, interactions with the culture medium and duration of preimplantation development [27]–[29], which makes the cow an excellent model for human reproductive research.…”

Section: Discussionmentioning

confidence: 99%

Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology

et al. 2011

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Elevated concentrations of serum non-esterified fatty acids (NEFA), associated with maternal disorders such as obesity and type II diabetes, alter the ovarian follicular micro-environment and have been associated with subfertility arising from reduced oocyte developmental competence. We have asked whether elevated NEFA concentrations during oocyte maturation affect the development and physiology of zygotes formed from such oocytes, using the cow as a model. The zygotes were grown to blastocysts, which were evaluated for their quality in terms of cell number, apoptosis, expression of key genes, amino acid turnover and oxidative metabolism. Oocyte maturation under elevated NEFA concentrations resulted in blastocysts with significantly lower cell number, increased apoptotic cell ratio and altered mRNA abundance of DNMT3A, IGF2R and SLC2A1. In addition, the blastocysts displayed reduced oxygen, pyruvate and glucose consumption, up-regulated lactate consumption and higher amino acid metabolism. These data indicate that exposure of maturing oocytes to elevated NEFA concentrations has a negative impact on fertility not only through a reduction in oocyte developmental capacity but through compromised early embryo quality, viability and metabolism.

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Section: Discussionmentioning

confidence: 99%

Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology

et al. 2011

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“…Personally, like many others (cf Cummins and Jequier 1995; Rieger 1998; Leese et al. 1998; Ménézo et al. 2000), I believe that the increasingly complicated procedures in use in today’s human ART clinics call for thorough comparative investigation in other mammals.…”

Section: The Value Of Comparative Studies To the Assisted Reproductiomentioning

confidence: 83%

Enigmas and Variations Among Mammalian Embryos

Betteridge

2001

Reprod Domestic Animals

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“…Growing evidence indicates that the cow is a more useful model for human preimplantation development than the mouse. Bovine and human embryos are similar with respect to microtubule patterns during fertilization, the timing of genome activation, metabolic requirements, interactions with the culture medium, and duration of preimplantation development (Navara et al, 1995; Anderiesz et al, 2000; Ménézo et al, 2000; Neuber and Powers, 2000; Niemann and Wrenzycki, 2000). While sNT is feasible in 10 species, it is most advanced in cattle (Niemann et al, 2004).…”

Section: Effects and Implications For Human Artmentioning

confidence: 99%

Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies

Wrenzycki¹,

Herrmann²,

Lucas‐Hahn³

et al. 2005

Birth Defects Research Pt C

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Knowledge about preimplantation development is important both for basic reproductive biology and for practical applications, including livestock breeding and regenerative medicine. During preimplantation development, epigenetic modifications such as DNA methylation and histone modifications are involved in the regulation of imprinted and nonimprinted genes, in the initiation of X chromosome inactivation, and the adjustment of telomere length. The underlying events are particularly vulnerable to external factors. Characterization of expression profiles in in vivo–derived embryos of different developmental stages and understanding the mechanisms and dynamics underlying the reprogramming process are the first steps towards the analysis of the complex gene regulatory networks. They provide a baseline for the analysis of manipulated embryos of all mammalian species, including humans, to improve embryo technologies and related therapeutic applications. Birth Defects Research (Part C) 75:1–9, 2005. © 2005 Wiley‐Liss, Inc.

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Assisted reproductive technology (ART) in humans: Facts and uncertainties

Cited by 47 publications

References 48 publications

Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology

Elevated Non-Esterified Fatty Acid Concentrations during Bovine Oocyte Maturation Compromise Early Embryo Physiology

Enigmas and Variations Among Mammalian Embryos

Epigenetic reprogramming throughout preimplantation development and consequences for assisted reproductive technologies

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