Assisted reproductive technology in Japan: A summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

Ishihara, Osamu; Jwa, Seung Chik; Kuwahara, Akira; Ishikawa, Takaaki; Kugu, Koji; Sawa, Rintaro; Banno, Kouji; Irahara, Minoru; Saito, Hidekazu

doi:10.1002/rmb2.12258

Cited by 28 publications

(36 citation statements)

References 15 publications

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“…Furthermore, it was reported by The Japan Society of Obstetrics and Gynecology that in 2016, there were 447,790 assisted reproductive technology cycles that were registered and 54,110 neonates were recorded, accounting for 1 in 18.1 neonates born in Japan (total number of neonates was 976,979 in 2016). 21 Consequently, it is assumed that a considerable number of patients are forced to undergo in vitro fertilization due to male reproductive-related factors.…”

Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan

et al. 2019

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Introduction: As a continuous decline in semen concentration has been reported, the concept of male infertility has gained increased attention. Although several surveys of semen quality have been conducted in young men in general, no study has reported only on newlywed men. Aim: The aim of this study was to evaluate semen quality and assess its characteristics in newlywed men. Methods: This study included 564 men visiting our hospital or clinic for fertility screening just before their wedding or as newlywed men. Based on the World Health Organization criteria, the rates of men who did not have a semen volume of !1.5 mL, a sperm concentration of !15 million/mL, and a sperm motility rate of !40% were calculated. The characteristics of the poor semen findings group with any 1 of the 3 items of semen volume, sperm concentration, or sperm motility rate not reaching the reference value were evaluated. Main Outcome Measure: Independent factors, which are involved in the poor semen findings group, were evaluated. Results: The poor findings in semen volume, sperm concentration, and sperm motility were found in 11.0%, 9.2%, and 10.6%, respectively. The poor semen findings group included 143 men (25.4%) with any 1 of the 3 items not reaching the reference value. As compared to the normal group, age and body mass index were significantly higher, testicular volume was significantly smaller, and blood gamma-glutamyltransferase and fasting blood sugar levels were significantly higher in the poor semen findings group. Logistic multivariate analysis, including symptom questionnaire scores, blood biochemistry items, and endocrinological items, showed 3 independent factors were involved in the poor semen findings group: age, luteinizing hormone, and erection (Erection Hardness Score). Conclusion: It was clarified that even among men beginning their attempts at pregnancy, semen findings were poor and erectile dysfunction was involved in poor semen quality in one-quarter of the men. Tsujimura A, Hiramatsu I, Nagashima Y, et al. Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan. Sex Med 2019;8:21e29.

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Section: Discussionmentioning

confidence: 99%

Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan

et al. 2019

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“…Second, the proportion of pregnant women ≥35 years old in our center was higher than the national average (28.6%), which was reported by the Statistics Bureau of the Ministry of Internal Affairs and Communications in Japan 11 . Third, the proportion of pregnant women with ART at our center (33.9%) was higher than the national average (5.5%) 12,13 . It was reported that pregnant women who received reproductive assistance preferred to undergo prenatal GT 14 …”

Section: Discussionmentioning

confidence: 76%

Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan

Shibata

Akaishi

Sasaki

et al. 2020

J of Obstet and Gynaecol

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Aim: To evaluate how many pregnant women would prefer to undergo prenatal genetic testing (GT) if they received adequate information during early gestation. Methods: We examined the preferences for prenatal GT among pregnant women visiting our general outpatient clinic before 16 weeks' gestation between September 2014 and September 2017. We provided them with informational brochures about prenatal GT at their first visit. Women always received genetic counseling (GC) before undergoing GT of their own choice. Results: Among 5700 pregnant women, 2077 (36.4%) received GC, and 1983 (34.8%) underwent some form of prenatal GT. The percentage undergoing GT was 9.4% (50/531) for women <30 years old, 19.0% (309/1623) for those 30-34 years old, 43.1% (989/2294) for those 35-39 years old, and 50.7% (635/1252) for those ≥40 years old. Older pregnant women tended to receive GC and GT more often than younger women (P < 0.001). The most common reason for receiving GC was advanced maternal age (79.7%). The most common prenatal GT was noninvasive prenatal testing (NIPT) (50%), followed by the combined test (29.0%) and quadruple test (11.2%). Pregnant women ≥35 years old tended to choose NIPT (60.5%), while those <35 years old tended to choose the combined test (52.9%). Conclusion: About one-third of the pregnant women preferred to receive prenatal GT by their own choice. Women's preferences for prenatal GT increased with maternal age; however, half of pregnant women with an advanced maternal age preferred not to undergo GT, even if they were well informed.

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“…Assisted reproductive technology (ART) is widespread in developed countries [1]. In Japan, 54,110 livebirths, accounting for one in 18.1 neonates, were born using ART in 2016 [2]. Artificial manipulations are possible to alter epigenetic modification of gametes and embryos.…”

Section: Introductionmentioning

confidence: 99%

Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years

et al. 2020

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Backgrounds: The proportion of assisted reproductive technology (ART)-conceived livebirths of patients with imprinting disorders (IDs) is higher than that of the general population. Whether this is due to ART or confounding effects of advanced parental age was not investigated. We examined the association of ART and parental ages at childbirth for the development of eight epimutation-mediated imprinting disorders (epi-IDs). Results: We enrolled 136 patients with epi-IDs and obtained general population ART data from the Japanese robust nationwide registry. We compared the proportion of ART-conceived livebirths and maternal childbearing ages between patients with epi-IDs and the general population. The proportion of ART-conceived livebirths in patients with epi-IDs was higher than that in mothers aged ≥ 30 years, the age group in which more than 90% of ART procedures performed. The maternal childbearing ages of patients with epi-IDs were widely distributed from 19 to 45 (median: 32) within the approximate 2.5th to 97.5th percentiles of maternal childbearing ages of the general population. In addition, we compared the proportion of ART-conceived livebirths and parental ages at childbirth across patients with eight epi-IDs. We demonstrated that more than 90% of ART-conceived patients with epi-IDs were found in Silver-Russell syndrome (SRS) and Beckwith-Wiedemann syndrome (BWS) patients, and parental ages were almost consistent in patients with eight epi-IDs, except Prader-Willi syndrome. Conclusions: According to the prerequisite that most of the ART procedures in Japan are performed on mothers aged ≥ 30 years, ART can be a risk factor for the development of epi-IDs, particularly SRS and BWS, for mothers aged ≥ 30 years.

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Assisted reproductive technology in Japan: A summary report for 2016 by the Ethics Committee of the Japan Society of Obstetrics and Gynecology

Cited by 28 publications

References 15 publications

Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan

Erectile Dysfunction is Predictive Symptom for Poor Semen in Newlywed Men in Japan

Pregnant women's preferences for prenatal genetic testing: A single‐center study in Japan

Assisted reproductive technology represents a possible risk factor for development of epimutation-mediated imprinting disorders for mothers aged ≥ 30 years

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