Assistência De Enfermagem Ao Paciente Com Complicações Da Covid-19

Torres, Barbara Vitória dos Santos; Júnior, Sandro Marcelo da Silva Ferreira; Filho, Ademar de Souza Silva; Silva, Álvaro Marinho da; Melo, Gercyelle Lima dos Santos; Santos, Emiliana Alves dos; Silva, Wanderson Carlos Nunes da; Santos, Yasmin Rayane Silva; Oliveira, Márcia Gabriele Ferreira de; Silva, Isamara Santos da; Soares, Jandson de Oliveira

doi:10.46898/rfb.9786558891116.1

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Apart from HLA-I, HLA-II also contributes to the development of T1D. HLA-II is also expressed in pancreatic b cells of patients with T1D, and HLA-II-expressing b cells may be the direct target of autoimmune CD4+ T cells (61,62). Therefore, HLA-II also plays a role in the pathogenesis of T1D (62).…”

Section: Potential Breakthrough Point For Targeted Therapies--cd8+ T ...mentioning

confidence: 99%

Autoimmune CD8+ T cells in type 1 diabetes: from single-cell RNA sequencing to T-cell receptor redirection

Yang,

Zhang,

Ding

et al. 2024

Front. Endocrinol.

View full text Add to dashboard Cite

Type 1 diabetes (T1D) is an organ-specific autoimmune disease caused by pancreatic β cell destruction and mediated primarily by autoreactive CD8+ T cells. It has been shown that only a small number of stem cell-like β cell-specific CD8+ T cells are needed to convert normal mice into T1D mice; thus, it is likely that T1D can be cured or significantly improved by modulating or altering self-reactive CD8+ T cells. However, stem cell-type, effector and exhausted CD8+ T cells play intricate and important roles in T1D. The highly diverse T-cell receptors (TCRs) also make precise and stable targeted therapy more difficult. Therefore, this review will investigate the mechanisms of autoimmune CD8+ T cells and TCRs in T1D, as well as the related single-cell RNA sequencing (ScRNA-Seq), CRISPR/Cas9, chimeric antigen receptor T-cell (CAR-T) and T-cell receptor-gene engineered T cells (TCR-T), for a detailed and clear overview. This review highlights that targeting CD8+ T cells and their TCRs may be a potential strategy for predicting or treating T1D.

show abstract

Section: Potential Breakthrough Point For Targeted Therapies--cd8+ T ...mentioning

confidence: 99%