2010
DOI: 10.1590/s1415-52732010000500018
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Associação da deficiência de ácido fólico com alterações patológicas e estratégias para sua prevenção: uma visão crítica

Abstract: A deficiência de ácido fólico está associada às doenças crônicas não-transmissíveis, complicações na gestação e doenças neurodegenerativas. Objetivou-se discutir o papel do ácido fólico na prevenção de doenças, os aspectos epidemiológicos de sua deficiência, fortificação dos alimentos e suplementação medicamentosa. Realizou-se levantamento bibliográfico, consultando as bases de dados para a obtenção dos artigos completos: MedLine, SciELO, PubMed, Highwire Press e Science Direct. Foram selecionados estudos real… Show more

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Cited by 8 publications
(2 citation statements)
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“…Added to food, this has a bioavailability 85-100% , while folate, in its natural form, present in fresh food, has a bioavailability of 50%, and is more susceptible to destruction in the preparation. 11,12 A daily dosage of 0.4 mg of folic acid is recommended for all women who plan to become pregnant; for those who have had children with problems or who use medications that interfere with folate levels in the body, such as anticonvulsants, the recommend dose is 4mg. 12 For lactating and pregnant women, an additional daily dose of 0.1 mg and 0.2 mg of folic acid is recommended, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…Added to food, this has a bioavailability 85-100% , while folate, in its natural form, present in fresh food, has a bioavailability of 50%, and is more susceptible to destruction in the preparation. 11,12 A daily dosage of 0.4 mg of folic acid is recommended for all women who plan to become pregnant; for those who have had children with problems or who use medications that interfere with folate levels in the body, such as anticonvulsants, the recommend dose is 4mg. 12 For lactating and pregnant women, an additional daily dose of 0.1 mg and 0.2 mg of folic acid is recommended, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…2 3 It can be also found in monoglutamate as a drug supplement, being quickly absorbed. 4 It has a pivotal role in purine and pyrimidine biosynthesis and consequently, in DNA and RNA formation. 5 It is also essential to specific metabolic reactions in the cell environment besides the growth and functioning of the organism.…”
Section: Introductionmentioning
confidence: 99%